PDB entry 6m64

View 6m64 on RCSB PDB site
Description: Crystal structure of SMAD2 in complex with CBP
Class: signaling protein
Keywords: TGF-beta, Complex, Transcription factor, SIGNALING PROTEIN
Deposited on 2020-03-13, released 2020-11-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-12-30, with a file datestamp of 2020-12-25.
Experiment type: XRAY
Resolution: 1.45 Å
R-factor: N/A
AEROSPACI score: 0.59 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mothers against decapentaplegic homolog 2
    Species: Homo sapiens [TaxId:9606]
    Gene: SMAD2, MADH2, MADR2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15796 (Start-204)
      • expression tag (205-207)
    Domains in SCOPe 2.08: d6m64a1, d6m64a2
  • Chain 'B':
    Compound: cbp
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6M64 (0-End)
  • Chain 'C':
    Compound: Mothers against decapentaplegic homolog 2
    Species: Homo sapiens [TaxId:9606]
    Gene: SMAD2, MADH2, MADR2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6m64c_
  • Chain 'D':
    Compound: cbp
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6M64 (0-End)
  • Chain 'E':
    Compound: Mothers against decapentaplegic homolog 2
    Species: Homo sapiens [TaxId:9606]
    Gene: SMAD2, MADH2, MADR2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6m64e_
  • Chain 'F':
    Compound: cbp
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6M64 (Start-27)
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6m64A (A:)
gpdlqpvtysepafwcsiayyelnqrvgetfhasqpsltvdgftdpsnserfclgllsnv
nrnatvemtrrhigrgvrlyyiggevfaeclsdsaifvqspncnqrygwhpatvckippg
cnlkifnnqefaallaqsvnqgfeavyqltrmctirmsfvkgwgaeyrrqtvtstpcwie
lhlngplqwldkvltqmgspsvrcseme

    Sequence, based on observed residues (ATOM records): (download) 
    >6m64A (A:)
pvtysepafwcsiayyelnqrvgetfhasqpsltvdgftdpsnserfclgllsnvnrnat
vemtrrhigrgvrlyyiggevfaeclsdsaifvqspncnqrygwhpatvckippgcnlki
fnnqefaallaqsvnqgfeavyqltrmctirmsfvkgwgaeyrrqtvtstpcwielhlng
plqwldkvltqmgspsvrcseme

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6m64C (C:)
gpdlqpvtysepafwcsiayyelnqrvgetfhasqpsltvdgftdpsnserfclgllsnv
nrnatvemtrrhigrgvrlyyiggevfaeclsdsaifvqspncnqrygwhpatvckippg
cnlkifnnqefaallaqsvnqgfeavyqltrmctirmsfvkgwgaeyrrqtvtstpcwie
lhlngplqwldkvltqmgspsvrcseme

    Sequence, based on observed residues (ATOM records): (download) 
    >6m64C (C:)
tysepafwcsiayyelnqrvgetfhasqpsltvdgftdpsnserfclgllsnvnrnatve
mtrrhigrgvrlyyiggevfaeclsdsaifvqspncnqrygwhpatvckippgcnlkifn
nqefaallaqsvnqgfeavyqltrmctirmsfvkgwgaeyrrqtvtstpcwielhlngpl
qwldkvltqmgsps

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6m64E (E:)
gpdlqpvtysepafwcsiayyelnqrvgetfhasqpsltvdgftdpsnserfclgllsnv
nrnatvemtrrhigrgvrlyyiggevfaeclsdsaifvqspncnqrygwhpatvckippg
cnlkifnnqefaallaqsvnqgfeavyqltrmctirmsfvkgwgaeyrrqtvtstpcwie
lhlngplqwldkvltqmgspsvrcseme

    Sequence, based on observed residues (ATOM records): (download) 
    >6m64E (E:)
vtysepafwcsiayyelnqrvgetfhasqpsltvdgftdpsnserfclgllsnvnrnatv
emtrrhigrgvrlyyiggevfaeclsdsaifvqspncnqrygwhpatvckippgcnlkif
nnqefaallaqsvnqgfeavyqltrmctirmsfvkgwgaeyrrqtvtstpcwielhlngp
lqwldkvltqmgs

  • Chain 'F':
    No sequence available.