PDB entry 6m5o

View 6m5o on RCSB PDB site
Description: Co-crystal structure of human serine hydroxymethyltransferase 2 in complex with Pyridoxal 5'-phosphate (PLP) and glycodeoxycholic acid
Class: transferase
Keywords: Inhibitor, Complex, TRANSFERASE
Deposited on 2020-03-11, released 2021-01-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-02-17, with a file datestamp of 2021-02-12.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine hydroxymethyltransferase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: SHMT2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6m5oa_
  • Chain 'B':
    Compound: Serine hydroxymethyltransferase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: SHMT2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6m5ob_
  • Heterogens: DXC, GLY, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6m5oA (A:)
mgsshhhhhhssglvprgsgqlvrmairaqhsnaaqtqtgeanrgwtgqeslsdsdpemw
ellqrekdrqcrgleliasenfcsraalealgsclnnkysegypgkryyggaevvdeiel
lcqrraleafdldpaqwgvnvqpysgspanlavytallqphdrimgldlpdgghlthgym
sdvkrisatsiffesmpyklnpktglidynqlaltarlfrprliiagtsayarlidyarm
revcdevkahlladmahisglvaakvipspfkhadivtttthktlrgarsglifyrkgvk
avdpktgreipytfedrinfavfpslqggphnhaiaavavalkqactpmfreyslqvlkn
aramadallergyslvsggtdnhlvlvdlrpkgldgaraervlelvsitankntcpgdrs
aitpgglrlgapaltsrqfreddfrrvvdfidegvniglevksktaklqdfksfllkdse
tsqrlanlrqrveqfarafpmpgfdeh

    Sequence, based on observed residues (ATOM records): (download) 
    >6m5oA (A:)
wtgqeslsdsdpemwellqrekdrqcrgleliasenfcsraalealgsclnnkysegypg
kryyggaevvdeiellcqrraleafdldpaqwgvnvqpysgspanlavytallqphdrim
gldlpdgghlthgymsdvkrisatsiffesmpyklnpktglidynqlaltarlfrprlii
agtsayarlidyarmrevcdevkahlladmahisglvaakvipspfkhadivtttthktl
rgarsglifyrkgvkavdpktgreipytfedrinfavfpslqggphnhaiaavavalkqa
ctpmfreyslqvlknaramadallergyslvsggtdnhlvlvdlrpkgldgaraervlel
vsitankntcpgdrsaitpgglrlgapaltsrqfreddfrrvvdfidegvniglevkskt
aklqdfksfllkdsetsqrlanlrqrveqfarafpmpgfdeh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6m5oB (B:)
mgsshhhhhhssglvprgsgqlvrmairaqhsnaaqtqtgeanrgwtgqeslsdsdpemw
ellqrekdrqcrgleliasenfcsraalealgsclnnkysegypgkryyggaevvdeiel
lcqrraleafdldpaqwgvnvqpysgspanlavytallqphdrimgldlpdgghlthgym
sdvkrisatsiffesmpyklnpktglidynqlaltarlfrprliiagtsayarlidyarm
revcdevkahlladmahisglvaakvipspfkhadivtttthktlrgarsglifyrkgvk
avdpktgreipytfedrinfavfpslqggphnhaiaavavalkqactpmfreyslqvlkn
aramadallergyslvsggtdnhlvlvdlrpkgldgaraervlelvsitankntcpgdrs
aitpgglrlgapaltsrqfreddfrrvvdfidegvniglevksktaklqdfksfllkdse
tsqrlanlrqrveqfarafpmpgfdeh

    Sequence, based on observed residues (ATOM records): (download) 
    >6m5oB (B:)
wtgqeslsdsdpemwellqrekdrqcrgleliasenfcsraalealgsclnnkysegypg
kryyggaevvdeiellcqrraleafdldpaqwgvnvqpysgspanlavytallqphdrim
gldlpdgghlthgymsdvkrisatsiffesmpyklnpktglidynqlaltarlfrprlii
agtsayarlidyarmrevcdevkahlladmahisglvaakvipspfkhadivtttthktl
rgarsglifyrkgvkavdpktgreipytfedrinfavfpslqggphnhaiaavavalkqa
ctpmfreyslqvlknaramadallergyslvsggtdnhlvlvdlrpkgldgaraervlel
vsitankntcpgdrsaitpgglrlgapaltsrqfreddfrrvvdfidegvniglevkskt
aklqdfksfllkdsetsqrlanlrqrveqfarafpmpgfdeh