PDB entry 6m4u
View 6m4u on RCSB PDB site
Description: Crystal structure of FKBP-FRB T2098L mutant in complex with rapamycin
Class: isomerase
Keywords: Rapamycin, complex, kinase, isomerase
Deposited on
2020-03-09, released
2020-08-26
The last revision prior to the SCOPe 2.07 freeze date was dated
2020-09-16, with a file datestamp of
2020-09-11.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.33
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Peptidyl-prolyl cis-trans isomerase FKBP1A
Species: Homo sapiens [TaxId:9606]
Gene: FKBP1A, FKBP1, FKBP12
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d6m4ua_ - Chain 'B':
Compound: Serine/threonine-protein kinase mTOR
Species: Homo sapiens [TaxId:9606]
Gene: mTOR
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d6m4ub_ - Chain 'E':
Compound: Peptidyl-prolyl cis-trans isomerase FKBP1A
Species: Homo sapiens [TaxId:9606]
Gene: FKBP1A, FKBP1, FKBP12
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d6m4ue1, d6m4ue2 - Chain 'F':
Compound: Serine/threonine-protein kinase mTOR
Species: Homo sapiens [TaxId:9606]
Gene: mTOR
Database cross-references and differences (RAF-indexed):
- Uniprot P42345 (2-94)
- expression tag (0-1)
- engineered mutation (79)
Domains in SCOPe 2.07: d6m4uf1, d6m4uf2 - Heterogens: RAP, ZN, CL, GOL, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>6m4uA (A:)
gsmgvqvetispgdgrtfpkrgqtcvvhytgmledgkkfdssrdrnkpfkfmlgkqevir
gweegvaqmsvgqrakltispdyaygatghpgiipphatlvfdvellkle
Sequence, based on observed residues (ATOM records): (download)
>6m4uA (A:)
mgvqvetispgdgrtfpkrgqtcvvhytgmledgkkfdssrdrnkpfkfmlgkqevirgw
eegvaqmsvgqrakltispdyaygatghpgiipphatlvfdvellkle
- Chain 'B':
Sequence, based on SEQRES records: (download)
>6m4uB (B:)
gsilwhemwhegleeasrlyfgernvkgmfevleplhammergpqtlketsfnqaygrdl
meaqewcrkymksgnvkdllqawdlyyhvfrrisk
Sequence, based on observed residues (ATOM records): (download)
>6m4uB (B:)
ilwhemwhegleeasrlyfgernvkgmfevleplhammergpqtlketsfnqaygrdlme
aqewcrkymksgnvkdllqawdlyyhvfrrisk
- Chain 'E':
Sequence; same for both SEQRES and ATOM records: (download)
>6m4uE (E:)
gsmgvqvetispgdgrtfpkrgqtcvvhytgmledgkkfdssrdrnkpfkfmlgkqevir
gweegvaqmsvgqrakltispdyaygatghpgiipphatlvfdvellkle
- Chain 'F':
Sequence; same for both SEQRES and ATOM records: (download)
>6m4uF (F:)
gsilwhemwhegleeasrlyfgernvkgmfevleplhammergpqtlketsfnqaygrdl
meaqewcrkymksgnvkdllqawdlyyhvfrrisk