PDB entry 6m4o

View 6m4o on RCSB PDB site
Description: cryo-em structure of the monomeric spt-ormdl3 complex
Deposited on 2020-03-08, released 2021-02-10
The last revision was dated 2021-03-24, with a file datestamp of 2021-03-19.
Experiment type: EM
Resolution: 3.4 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ORM1-like protein 3
    Species: Homo sapiens [TaxId:9606]
    Gene: ORMDL3
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Serine palmitoyltransferase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: SPTLC1, LCB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Serine palmitoyltransferase small subunit A
    Species: Homo sapiens [TaxId:9606]
    Gene: SPTSSA, C14orf147, SSSPTA
    Database cross-references and differences (RAF-indexed):
  • Chain 'S':
    Compound: Serine palmitoyltransferase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: SPTLC1, LCB1
    Database cross-references and differences (RAF-indexed):
  • Chain 'T':
    Compound: Serine palmitoyltransferase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: SPTLC2, KIAA0526, LCB2
    Database cross-references and differences (RAF-indexed):
  • Heterogens: PLP

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6m4oA (A:)
mnvgtahsevnpntrvmnsrgiwlsyvlaigllhivllsipfvsvpvvwtltnlihnmgm
yiflhtvkgtpfetpdqgkarllthweqmdygvqftasrkfltitpivlyfltsfytkyd
qihfvlntvslmsvlipklpqlhgvrifginky

    Sequence, based on observed residues (ATOM records):
    >6m4oA (A:)
pntrvmnsrgiwlsyvlaigllhivllsipfvsvpvvwtltnlihnmgmyiflhtvkgtp
fetpdqgkarllthweqmdygvqftasrkfltitpivlyfltsfytkydqihfvlntvsl
msvlipklpqlhgvrifgi

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6m4oB (B:)
matateqwvlvemvqalyeapayhlilegililwiirllfsktyklqersdltvkekeel
ieewqpeplvppvpkdhpalnynivsgppshktvvngkecinfasfnflglldnprvkaa
alaslkkygvgtcgprgfygtfdvhldledrlakfmkteeaiiysygfatiasaipaysk
rgdivfvdraacfaiqkglqasrsdiklfkhndmadlerllkeqeiedqknprkarvtrr
fivveglymntgticplpelvklkykykarifleeslsfgvlgehgrgvtehyginiddi
dlisanmenalasiggfccgrsfvidhqrlsgqgycfsaslppllaaaaiealnimeenp
gifavlkekcgqihkalqgisglkvvgeslspafhlqleestgsreqdvrllqeivdqcm
nrsialtqarylekeekclpppsirvvvtveqteeeleraastikevaqavll

    Sequence, based on observed residues (ATOM records):
    >6m4oB (B:)
yeapayhlilegililwiirllfsktyk

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6m4oE (E:)
madykddddksgpdevdasgrmagmalarawkqmswfyyqyllvtalymlepwertvfns
mlvsivgmalytgyvfmpqhimailhyfeivq

    Sequence, based on observed residues (ATOM records):
    >6m4oE (E:)
arawkqmswfyyqyllvtalymlepwertvfnsmlvsivgmalytgyvf

  • Chain 'S':
    Sequence, based on SEQRES records:
    >6m4oS (S:)
matateqwvlvemvqalyeapayhlilegililwiirllfsktyklqersdltvkekeel
ieewqpeplvppvpkdhpalnynivsgppshktvvngkecinfasfnflglldnprvkaa
alaslkkygvgtcgprgfygtfdvhldledrlakfmkteeaiiysygfatiasaipaysk
rgdivfvdraacfaiqkglqasrsdiklfkhndmadlerllkeqeiedqknprkarvtrr
fivveglymntgticplpelvklkykykarifleeslsfgvlgehgrgvtehyginiddi
dlisanmenalasiggfccgrsfvidhqrlsgqgycfsaslppllaaaaiealnimeenp
gifavlkekcgqihkalqgisglkvvgeslspafhlqleestgsreqdvrllqeivdqcm
nrsialtqarylekeekclpppsirvvvtveqteeeleraastikevaqavll

    Sequence, based on observed residues (ATOM records):
    >6m4oS (S:)
tvkekeelieewqpeplvppvpkdhpalnynivsgppshktvvngkecinfasfnflgll
dnprvkaaalaslkkygvgtcgprgfygtfdvhldledrlakfmkteeaiiysygfatia
saipayskrgdivfvdraacfaiqkglqasrsdiklfkhndmadlerllkeqeiedqknp
rkarvtrrfivveglymntgticplpelvklkykykarifleeslsfgvlgehgrgvteh
yginiddidlisanmenalasiggfccgrsfvidhqrlsgqgycfsaslppllaaaaiea
lnimeenpgifavlkekcgqihkalqgisglkvvgeslspafhlqleestgsreqdvrll
qeivdqcmnrsialtqarylekeekclpppsirvvvtveqteeeleraastikevaqavl

  • Chain 'T':
    Sequence, based on SEQRES records:
    >6m4oT (T:)
mrpepggcccrrtvrangcvangevrngyvrssaaaaaaaaagqihhvtqngglykrpfn
eafeetpmlvavltyvgygvltlfgylrdflrywriekchhatereeqkdfvslyqdfen
fytrnlymrirdnwnrpicsvpgarvdimerqshdynwsfkytgniikgvinmgsynylg
farntgscqeaaakvleeygagvcstrqeignldkheeleelvarflgveaamaygmgfa
tnsmnipalvgkgclilsdelnhaslvlgarlsgatirifkhnnmqslekllkdaivygq
prtrrpwkkililvegiysmegsivrlpevialkkkykaylyldeahsigalgptgrgvv
eyfgldpedvdvmmgtftksfgasggyiggkkelidylrthshsavyatslsppvveqii
tsmkcimgqdgtslgkecvqqlaentryfrrrlkemgfiiygnedspvvplmlympakig
afgremlkrnigvvvvgfpatpiiesrarfclsaahtkeildtalkeidevgdllqlkys
rhrlvplldrpfdettyeeted

    Sequence, based on observed residues (ATOM records):
    >6m4oT (T:)
ihhvtqngglykrpfneafeetpmlvavltyvgygvltlfgylrdflrywrchhateree
qkdfvslyqdfenfytrnlymrirdnwnrpicsvpgarvdimerqshdynwsfkytgnii
kgvinmgsynylgfarntgscqeaaakvleeygagvcstrqeignldkheeleelvarfl
gveaamaygmgfatnsmnipalvgkgclilsdelnhaslvlgarlsgatirifkhnnmqs
lekllkdaivygqprtrrpwkkililvegiysmegsivrlpevialkkkykaylyldeah
sigalgptgrgvveyfgldpedvdvmmgtftksfgasggyiggkkelidylrthshsavy
atslsppvveqiitsmkcimgslgkecvqqlaentryfrrrlkemgfiiygnedspvvpl
mlympakigafgremlkrnigvvvvgfpatpiiesrarfclsaahtkeildtalkeidev
gdllqlkysrh