PDB entry 6m49

View 6m49 on RCSB PDB site
Description: cryo-em structure of scap/insig complex in the present of 25-hydroxyl cholesterol.
Deposited on 2020-03-06, released 2021-01-20
The last revision was dated 2021-03-17, with a file datestamp of 2021-03-12.
Experiment type: EM
Resolution: 3.7 Å
R-factor: N/A
AEROSPACI score: 0.12 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Insulin-induced gene 2 protein
    Species: Homo sapiens [TaxId:9606]
    Gene: INSIG2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y5U4
      • engineered mutation (89)
  • Chain 'B':
    Compound: Sterol regulatory element-binding protein cleavage-activating protein,Sterol regulatory element-binding protein cleavage-activating protein
    Species: Homo sapiens [TaxId:9606]
    Gene: scap
    Database cross-references and differences (RAF-indexed):
  • Heterogens: HC3

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6m49A (A:)
maegetespgpkksgpyissvtsqsvnlmirgvvlffigvflalvlnllqiqrnvtlfpp
dviasifssawwvppccgtasavigllypsidrhlgephkfkrewssvmrcvavfvginh
asakvdfdnniqlsltlaalsiglwwtfdrsrsgfglgvgiaflatvvtqllvyngvyqy
tspdflyvrswlpciffaggitmgnigrqlamyeskviaekshqe

    Sequence, based on observed residues (ATOM records):
    >6m49A (A:)
issvtsqsvnlmirgvvlffigvflalvlnllqiqrndviasifssawwvppccgtasav
igllypsidrhlgephkfkrewssvmrcvavfvginhasakvdfdnniqlsltlaalsig
lwwtfdrsrsgfglgvgiaflatvvtqllvynflyvrswlpciffaggitmgnigrqlam
ye

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6m49B (B:)
mtlterlrekisrafynhgllcasypipiilftgfcilaccypllklplpgtvpgkysgv
slytrkrmvsytitlvfqhyhakflgslrarlmllhpspncslraeslvhvhfkeeigva
eliplvttyiilfayiyfstrkidmvkskwglalaavvtvlssllmsvglctlfgltptl
nggeifpylvvviglenvlvltksvvstpvdlevklriaqglsseswsimknmatelgii
ligyftlvpaiqefclfavvglvsdfflqmlffttvlsidirrmeladlnkrlppeaclp
sakpvgqptryerqlavrpstphtitlqpssfrnlrlpkrlrvvyflartrlaqrlimag
tvvwigilvytdpaglrnylaaqvteqsplgegalapmpvpsgmlppshpdpafsifppd
apklpenqtspgesperggpaevvhdspvpevtwgpedeelwrklsfrhwptlfsyynit
lakryisllpvipvtlrlnprealegrhpqdgrsawpppgpipaghweagpkgpggvqah
gdvtlykvaalglatgivlvllllclyrvlcp

    Sequence, based on observed residues (ATOM records):
    >6m49B (B:)
erlrekisrafynhgllcasypipiilftgfcilaccypllklvaeliplvttyiilfay
iyfstrkidmvkskwglalaavvtvlssllmsvglctlfgltptlnggeifpylvvvigl
envlvltksvvstpvdlevklriaqglsseswsimknmatelgiiligyftlvpaiqefc
lfavvglvsdfflqmlffttvlsidirrmelarlaqrlimagtvvwigilvytdpagl