PDB entry 6m2b

View 6m2b on RCSB PDB site
Description: Crystal structure of human dihydroorotate dehydrogenase (DHODH) with S416
Class: oxidoreductase
Keywords: inhibitor, complex, BIOSYNTHETIC PROTEIN, OXIDOREDUCTASE
Deposited on 2020-02-27, released 2021-03-03
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-03-03, with a file datestamp of 2021-02-26.
Experiment type: XRAY
Resolution: 1.76 Å
R-factor: N/A
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydroorotate dehydrogenase (quinone), mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: DHODH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6m2ba_
  • Heterogens: EZO, FMN, ORO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6m2bA (A:)
mghhhhhhhhhhssghiddddkhmatgderfyaehlmptlqglldpesahrlavrftslg
llprarfqdsdmlevrvlghkfrnpvgiaagfdkhgeavdglykmgfgfveigsvtpkpq
egnprprvfrlpedqavinrygfnshglsvvehrlrarqqkqakltedglplgvnlgknk
tsvdaaedyaegvrvlgpladylvvnvsspntaglrslqgkaelrrlltkvlqerdglrr
vhrpavlvkiapdltsqdkediasvvkelgidglivtnttvsrpaglqgalrsetgglsg
kplrdlstqtiremyaltqgrvpiigvggvssgqdalekiragaslvqlytaltfwgppv
vgkvkreleallkeqgfggvtdaigadhrr

    Sequence, based on observed residues (ATOM records): (download) 
    >6m2bA (A:)
tgderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfrnp
vgiaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfns
hglsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylvv
nvsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkediasv
vkelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpii
gvggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdaig
adhrr