PDB entry 6lxy

View 6lxy on RCSB PDB site
Description: IRAK4 in complex with inhibitor
Class: transferase/transferase inhibitor
Keywords: IRAK4, KINASE, INHIBITOR, CANCER, SIGNALING PROTEIN, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2020-02-12, released 2020-11-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-11-25, with a file datestamp of 2020-11-20.
Experiment type: XRAY
Resolution: 2.19 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: interleukin-1 receptor-associated kinase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: Irak4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6lxya_
  • Chain 'B':
    Compound: interleukin-1 receptor-associated kinase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: Irak4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6lxyb_
  • Chain 'D':
    Compound: interleukin-1 receptor-associated kinase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: Irak4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6lxyd_
  • Chain 'E':
    Compound: interleukin-1 receptor-associated kinase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: Irak4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6lxye_
  • Heterogens: EXF, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6lxyA (A:)
gamgvsdtrfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkkl
aamvditteelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldrls
cldgtpplswhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfglara
sekfaqtvmtsrivgttaymapealrgeitpksdiysfgvvlleiitglpavdehrepql
lldikeeiedeektiedyidkkmndadstsveamysvasqclhekknkrpdikkvqqllq
emtas

    Sequence, based on observed residues (ATOM records): (download) 
    >6lxyA (A:)
trfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkklaamvdit
teelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldrlscldgtpp
lswhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfglarasekqtvm
tsrivgttaymapealrgeitpksdiysfgvvlleiitglpavdehrepqllldikeeie
deektiedyidkkmndadstsveamysvasqclhekknkrpdikkvqqllqemt

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6lxyB (B:)
gamgvsdtrfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkkl
aamvditteelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldrls
cldgtpplswhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfglara
sekfaqtvmtsrivgttaymapealrgeitpksdiysfgvvlleiitglpavdehrepql
lldikeeiedeektiedyidkkmndadstsveamysvasqclhekknkrpdikkvqqllq
emtas

    Sequence, based on observed residues (ATOM records): (download) 
    >6lxyB (B:)
trfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkklaamvdit
teelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldrlscldgtpp
lswhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfglarasekfaqt
vmtsrivgttaymapealrgeitpksdiysfgvvlleiitglpavdehrepqllldikee
iedeektiedyidkkmndadstsveamysvasqclhekknkrpdikkvqqllqemta

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6lxyD (D:)
gamgvsdtrfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkkl
aamvditteelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldrls
cldgtpplswhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfglara
sekfaqtvmtsrivgttaymapealrgeitpksdiysfgvvlleiitglpavdehrepql
lldikeeiedeektiedyidkkmndadstsveamysvasqclhekknkrpdikkvqqllq
emtas

    Sequence, based on observed residues (ATOM records): (download) 
    >6lxyD (D:)
dtrfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkklaamvdi
tteelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldrlscldgtp
plswhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfglaraqtvmts
rivgttaymapealrgeitpksdiysfgvvlleiitglpavdehrepqllldikeeiede
ektiedyidkkmndadstsveamysvasqclhekknkrpdikkvqqllqemta

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6lxyE (E:)
gamgvsdtrfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkkl
aamvditteelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldrls
cldgtpplswhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfglara
sekfaqtvmtsrivgttaymapealrgeitpksdiysfgvvlleiitglpavdehrepql
lldikeeiedeektiedyidkkmndadstsveamysvasqclhekknkrpdikkvqqllq
emtas

    Sequence, based on observed residues (ATOM records): (download) 
    >6lxyE (E:)
rfhsfsfyelknvtnnfderpisvggnkmgeggfgvvykgyvnnttvavkklaamvditt
eelkqqfdqeikvmakcqhenlvellgfssdgddlclvyvympngslldrlscldgtppl
swhmrckiaqgaanginflhenhhihrdiksanilldeaftakisdfglaravmtsrivg
ttaymapealrgeitpksdiysfgvvlleiitglpavdehrepqllldikeeiedeekti
edyidkkmndadstsveamysvasqclhekknkrpdikkvqqllqemt