PDB entry 6lxa

View 6lxa on RCSB PDB site
Description: X-ray structure of human PPARalpha ligand binding domain-eicosapentaenoic acid (EPA) co-crystals obtained by delipidation and cross-seeding
Class: transcription
Keywords: Nuclear receptor, Protein-ligand complex, PPAR, Transcription
Deposited on 2020-02-10, released 2020-11-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-12-02, with a file datestamp of 2020-11-27.
Experiment type: XRAY
Resolution: 1.23 Å
R-factor: N/A
AEROSPACI score: 0.74 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Peroxisome proliferator-activated receptor alpha
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q07869 (4-272)
      • expression tag (3)
    Domains in SCOPe 2.08: d6lxaa1, d6lxaa2
  • Heterogens: EPA, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6lxaA (A:)
gshmtadlkslakriyeaylknfnmnkvkarvilsgkasnnppfvihdmetlcmaektlv
aklvangiqnkeaevrifhccqctsvetvteltefakaipgfanldlndqvtllkygvye
aifamlssvmnkdgmlvaygngfitreflkslrkpfcdimepkfdfamkfnalelddsdi
slfvaaiiccgdrpgllnvghiekmqegivhvlrlhlqsnhpddiflfpkllqkmadlrq
lvtehaqlvqiikktesdaalhpllqeiyrdmy

    Sequence, based on observed residues (ATOM records): (download) 
    >6lxaA (A:)
mtadlkslakriyeaylknfnmnkvkarvilsgksnnppfvihdmetlcmaektlvaklv
angiqnkeaevrifhccqctsvetvteltefakaipgfanldlndqvtllkygvyeaifa
mlssvmnkdgmlvaygngfitreflkslrkpfcdimepkfdfamkfnalelddsdislfv
aaiiccgdrpgllnvghiekmqegivhvlrlhlqsnhpddiflfpkllqkmadlrqlvte
haqlvqiikktesdaalhpllqeiyrdmy