PDB entry 6lx3

View 6lx3 on RCSB PDB site
Description: Cryo-EM structure of human secretory immunoglobulin A
Class: immune system
Keywords: immunoglobulin, dimer, transcytosis, secreted, IMMUNE SYSTEM
Deposited on 2020-02-10, released 2020-05-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-22, with a file datestamp of 2020-07-17.
Experiment type: EM
Resolution: 3.15 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Interleukin-2,Immunoglobulin heavy constant alpha 1
    Species: Homo sapiens [TaxId:9606]
    Gene: IGHA1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6lx3a1, d6lx3a2
  • Chain 'B':
    Compound: Interleukin-2,Immunoglobulin heavy constant alpha 1
    Species: Homo sapiens [TaxId:9606]
    Gene: IGHA1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6lx3b1, d6lx3b2
  • Chain 'C':
    Compound: Interleukin-2,Immunoglobulin heavy constant alpha 1
    Species: Homo sapiens [TaxId:9606]
    Gene: IGHA1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6lx3c1, d6lx3c2
  • Chain 'D':
    Compound: Interleukin-2,Immunoglobulin heavy constant alpha 1
    Species: Homo sapiens [TaxId:9606]
    Gene: IGHA1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6lx3d1, d6lx3d2
  • Chain 'J':
    Compound: Immunoglobulin J chain
    Species: Homo sapiens [TaxId:9606]
    Gene: JCHAIN, IGCJ, IGJ
    Database cross-references and differences (RAF-indexed):
  • Chain 'P':
    Compound: Polymeric immunoglobulin receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: PIGR
    Database cross-references and differences (RAF-indexed):

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6lx3A (A:)
myrmqllscialslalvtnsarihmsawshpqfekgggsgggsggsawshpqfekidttc
chprlslhrpaledlllgseanltctltglrdasgvtftwtpssgksavqgpperdlcgc
ysvssvlpgcaepwnhgktftctaaypesktpltatlsksgntfrpevhllpppseelal
nelvtltclargfspkdvlvrwlqgsqelprekyltwasrqepsqgtttfavtsilrvaa
edwkkgdtfscmvghealplaftqktidrlagkpthvnvsvvmaevdgtcy

    Sequence, based on observed residues (ATOM records): (download) 
    >6lx3A (A:)
prlslhrpaledlllgseanltctltgtftwtpksavqgpperdlcgcysvssvlpgcae
pwnhgktftctaaypesktpltatlsksgntfrpevhllpppseelalnelvtltclarg
fspkdvlvrwlqgsqelprekyltwasrqepsqgtttfavtsilrvaaedwkkgdtfscm
vghealplaftqktidrlagvnvsvvmaevdgtcy

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6lx3B (B:)
myrmqllscialslalvtnsarihmsawshpqfekgggsgggsggsawshpqfekidttc
chprlslhrpaledlllgseanltctltglrdasgvtftwtpssgksavqgpperdlcgc
ysvssvlpgcaepwnhgktftctaaypesktpltatlsksgntfrpevhllpppseelal
nelvtltclargfspkdvlvrwlqgsqelprekyltwasrqepsqgtttfavtsilrvaa
edwkkgdtfscmvghealplaftqktidrlagkpthvnvsvvmaevdgtcy

    Sequence, based on observed residues (ATOM records): (download) 
    >6lx3B (B:)
prlslhrpaledlllgseanltctltglrdasgvtftwgksavqgppsvssvlpgcaepw
nhgktftctaaypesktpltatlsksgntfrpevhllpppseelalnelvtltclargfs
pkdvlvrwlqgsqelprekyltwasrqepsqgtttfavtsilrvaaedwkkgdtfscmvg
healplaftqktidrlahvnvsvvma

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6lx3C (C:)
myrmqllscialslalvtnsarihmsawshpqfekgggsgggsggsawshpqfekidttc
chprlslhrpaledlllgseanltctltglrdasgvtftwtpssgksavqgpperdlcgc
ysvssvlpgcaepwnhgktftctaaypesktpltatlsksgntfrpevhllpppseelal
nelvtltclargfspkdvlvrwlqgsqelprekyltwasrqepsqgtttfavtsilrvaa
edwkkgdtfscmvghealplaftqktidrlagkpthvnvsvvmaevdgtcy

    Sequence, based on observed residues (ATOM records): (download) 
    >6lx3C (C:)
prlslhrpaledlllgseanltctltglrdtftwtpksavqgpperdcysvssvlpgcae
pwnhgktftctaaypesktpltatlsksgntfrpevhllpppseelalnelvtltclarg
fspkdvlvrwlqgsqelprekyltwasrqepstttfavtsilrvaaedwkkgdtfscmvg
healplaftqktidrlagkpthvnvsvvm

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6lx3D (D:)
myrmqllscialslalvtnsarihmsawshpqfekgggsgggsggsawshpqfekidttc
chprlslhrpaledlllgseanltctltglrdasgvtftwtpssgksavqgpperdlcgc
ysvssvlpgcaepwnhgktftctaaypesktpltatlsksgntfrpevhllpppseelal
nelvtltclargfspkdvlvrwlqgsqelprekyltwasrqepsqgtttfavtsilrvaa
edwkkgdtfscmvghealplaftqktidrlagkpthvnvsvvmaevdgtcy

    Sequence, based on observed residues (ATOM records): (download) 
    >6lx3D (D:)
prlslhrpaledlllgseanltctltglrdasgvtftwtpssgksavqgppeysvssvlp
gcaepwnhgktftctaaypesktpltatlsksgntfrpevhllpppseelalnelvtltc
largfspkdvlvrwlqgsqelprekyltwasrqepsqgtttfavtsilrvaaedwkkgdt
fscmvghealplaftqktidrlagkpthvnvsvvmaevdgtcy

  • Chain 'J':
    No sequence available.

  • Chain 'P':
    No sequence available.