PDB entry 6lwj

View 6lwj on RCSB PDB site
Description: crystal structure of human neil1(p2g, e3q, k242) bound to duplex dna containing dihydrouracil (dhu)
Deposited on 2020-02-07, released 2021-06-09
The last revision was dated 2021-07-14, with a file datestamp of 2021-07-09.
Experiment type: XRAY
Resolution: 2.83 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Endonuclease 8-like 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NEIL1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96FI4 (0-294)
      • engineered mutation (1-2)
  • Chain 'B':
    Compound: DNA (5'-d(*cp*gp*tp*cp*cp*ap*(udh)p*gp*tp*cp*tp*ap*c)-3')
    Species: Escherichia coli, synthetic [TaxId:562]
  • Chain 'C':
    Compound: DNA (5'-d(*tp*ap*gp*ap*cp*cp*tp*gp*gp*ap*cp*gp*g)-3')
    Species: Escherichia coli, synthetic [TaxId:562]
  • Chain 'D':
    Compound: Endonuclease 8-like 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NEIL1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96FI4 (0-294)
      • engineered mutation (1-2)
  • Chain 'E':
    Compound: DNA (5'-d(*cp*gp*tp*cp*cp*ap*(udh)p*gp*tp*cp*tp*ap*c)-3')
    Species: Escherichia coli, synthetic [TaxId:562]
  • Chain 'F':
    Compound: DNA (5'-d(*tp*ap*gp*ap*cp*cp*tp*gp*gp*ap*cp*gp*g)-3')
    Species: Escherichia coli, synthetic [TaxId:562]
  • Chain 'G':
    Compound: Endonuclease 8-like 1
    Species: Homo sapiens [TaxId:9606]
    Gene: NEIL1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96FI4 (0-294)
      • engineered mutation (1-2)
  • Chain 'H':
    Compound: DNA (5'-d(*cp*gp*tp*cp*cp*ap*(udh)p*gp*tp*cp*tp*ap*c)-3')
    Species: Escherichia coli, synthetic [TaxId:562]
  • Chain 'I':
    Compound: DNA (5'-d(*tp*ap*gp*ap*cp*cp*tp*gp*gp*ap*cp*gp*g)-3')
    Species: Escherichia coli, synthetic [TaxId:562]
  • Heterogens: GOL, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6lwjA (A:)
mgqgpelhlasqfvneacralvfggcvekssvsrnpevpfessayrisasargkelrlil
splpgaqpqqeplalvfrfgmsgsfqlvpreelprhahlrfytappgprlalcfvdirrf
grwdlggkwqpgrgpcvlqeyqqfrenvlrnladkafdrpicealldqrffngignylra
eilyrlkippfekarsvlealqqhrpspeltlsqkirtklqnpdllelchsvpkevvqlg
gkgygsesgeedfaafrawlrcygmpgmsslqdrhgrtiwfqgdpgplapkgrks

    Sequence, based on observed residues (ATOM records):
    >6lwjA (A:)
gqgpelhlasqfvneacralvfggcvekssvsrnpevpfessayrisasargkelrlils
plpgaqpqqeplalvfrfgmsgsfqlvpreelprhahlrfytappgprlalcfvdirrfg
rwdlggkwqpgrgpcvlqeyqqfrenvlrnladkafdrpicealldqrffngignylrae
ilyrlkippfekarsvlealqnpdllelchsvpkevvqlggkgygeedfaafrawlrcyg
mpgmsslqdrhgrtiwfqgdpgplap

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6lwjD (D:)
mgqgpelhlasqfvneacralvfggcvekssvsrnpevpfessayrisasargkelrlil
splpgaqpqqeplalvfrfgmsgsfqlvpreelprhahlrfytappgprlalcfvdirrf
grwdlggkwqpgrgpcvlqeyqqfrenvlrnladkafdrpicealldqrffngignylra
eilyrlkippfekarsvlealqqhrpspeltlsqkirtklqnpdllelchsvpkevvqlg
gkgygsesgeedfaafrawlrcygmpgmsslqdrhgrtiwfqgdpgplapkgrks

    Sequence, based on observed residues (ATOM records):
    >6lwjD (D:)
gqgpelhlasqfvneacralvfggcvekssvsrnpevpfessayrisasargkelrlils
plpgaqpqqeplalvfrfgmsgsfqlvpreelprhahlrfytappgprlalcfvdirrfg
rwdlggkwqpgrgpcvlqeyqqfrenvlrnladkafdrpicealldqrffngignylrae
ilyrlkippfekarsvlealqpdllelchsvpkevvqlggkgygeedfaafrawlrcygm
pgmsslqdrhgrtiwfqgdpgplap

  • Chain 'E':
    No sequence available.

  • Chain 'F':
    No sequence available.

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6lwjG (G:)
mgqgpelhlasqfvneacralvfggcvekssvsrnpevpfessayrisasargkelrlil
splpgaqpqqeplalvfrfgmsgsfqlvpreelprhahlrfytappgprlalcfvdirrf
grwdlggkwqpgrgpcvlqeyqqfrenvlrnladkafdrpicealldqrffngignylra
eilyrlkippfekarsvlealqqhrpspeltlsqkirtklqnpdllelchsvpkevvqlg
gkgygsesgeedfaafrawlrcygmpgmsslqdrhgrtiwfqgdpgplapkgrks

    Sequence, based on observed residues (ATOM records):
    >6lwjG (G:)
gqgpelhlasqfvneacvekssvsrnpevpfyrisasargkelrlilspvfrfgmsgsfq
lvpreelprhahlrfytappgalcfvdirrfgrwdlggkwqpgrgpcvlqeyqqfrenvl
rnladkafdrpicealldqrffngignylraeilyrlkippfekarsvleapdllelchs
vpkevvqleedfaafrawlrcygmpgmsslqdrhgrtiwfqgdpgpla

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    No sequence available.