PDB entry 6lur

View 6lur on RCSB PDB site
Description: human puf60 uhm domain (thioredoxin fusion) in complex with a small molecule binder
Deposited on 2020-01-30, released 2020-04-29
The last revision was dated 2020-12-09, with a file datestamp of 2020-12-04.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thioredoxin 1,Poly(U)-binding-splicing factor PUF60
    Species: Homo sapiens [TaxId:9606]
    Gene: PUF60, FIR, ROBPI, SIAHBP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0AA25 (Start-117)
      • linker (118-121)
    • Uniprot Q9UHX1 (122-221)
  • Chain 'B':
    Compound: Thioredoxin 1,Poly(U)-binding-splicing factor PUF60
    Species: Homo sapiens [TaxId:9606]
    Gene: PUF60, FIR, ROBPI, SIAHBP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0AA25 (Start-117)
      • linker (118-121)
    • Uniprot Q9UHX1 (122-221)
  • Chain 'C':
    Compound: Thioredoxin 1,Poly(U)-binding-splicing factor PUF60
    Species: Homo sapiens [TaxId:9606]
    Gene: PUF60, FIR, ROBPI, SIAHBP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0AA25 (Start-117)
      • linker (118-121)
    • Uniprot Q9UHX1 (122-221)
  • Chain 'D':
    Compound: Thioredoxin 1,Poly(U)-binding-splicing factor PUF60
    Species: Homo sapiens [TaxId:9606]
    Gene: PUF60, FIR, ROBPI, SIAHBP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0AA25 (9-117)
      • linker (118-121)
    • Uniprot Q9UHX1 (122-221)
  • Chain 'E':
    Compound: Thioredoxin 1,Poly(U)-binding-splicing factor PUF60
    Species: Homo sapiens [TaxId:9606]
    Gene: PUF60, FIR, ROBPI, SIAHBP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0AA25 (Start-117)
      • linker (118-121)
    • Uniprot Q9UHX1 (122-221)
  • Chain 'F':
    Compound: Thioredoxin 1,Poly(U)-binding-splicing factor PUF60
    Species: Homo sapiens [TaxId:9606]
    Gene: PUF60, FIR, ROBPI, SIAHBP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0AA25 (Start-117)
      • linker (118-121)
    • Uniprot Q9UHX1 (122-221)
  • Chain 'G':
    Compound: Thioredoxin 1,Poly(U)-binding-splicing factor PUF60
    Species: Homo sapiens [TaxId:9606]
    Gene: PUF60, FIR, ROBPI, SIAHBP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0AA25 (Start-117)
      • linker (118-121)
    • Uniprot Q9UHX1 (122-221)
  • Chain 'H':
    Compound: Thioredoxin 1,Poly(U)-binding-splicing factor PUF60
    Species: Homo sapiens [TaxId:9606]
    Gene: PUF60, FIR, ROBPI, SIAHBP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0AA25 (Start-117)
      • linker (118-121)
    • Uniprot Q9UHX1 (122-221)
  • Heterogens: EVU, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6lurA (A:)
mkhhhhhhpmsdkiihltddsfdtdvlkadgailvdfwaewcgpckmiapildeiadeyq
gkltvaklnidqnpgtapkygirgiptlllfkngevaatkvgalskgqlkefldanlags
amestvmvlrnmvdpkdidddlegevteecgkfgavnrviiyqekqgeeedaeiivkifv
efsiasethkaiqalngrwfagrkvvaevydqerfdnsdlsa

    Sequence, based on observed residues (ATOM records):
    >6lurA (A:)
dkiihltddsfdtdvlkadgailvdfwaewcgpckmiapildeiadeyqgkltvaklnid
qnpgtapkygirgiptlllfkngevaatkvgalskgqlkefldanlagsamestvmvlrn
mvdpkdidddlegevteecgkfgavnrviiyqekqgeeedaeiivkifvefsiasethka
iqalngrwfagrkvvaevydqerfdnsdlsa

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6lurB (B:)
mkhhhhhhpmsdkiihltddsfdtdvlkadgailvdfwaewcgpckmiapildeiadeyq
gkltvaklnidqnpgtapkygirgiptlllfkngevaatkvgalskgqlkefldanlags
amestvmvlrnmvdpkdidddlegevteecgkfgavnrviiyqekqgeeedaeiivkifv
efsiasethkaiqalngrwfagrkvvaevydqerfdnsdlsa

    Sequence, based on observed residues (ATOM records):
    >6lurB (B:)
dkiihltddsfdtdvlkadgailvdfwaewcgpckmiapildeiadeyqgkltvaklnid
qnpgtapkygirgiptlllfkngevaatkvgalskgqlkefldanlagsamestvmvlrn
mvdpkdidddlegevteecgkfgavnrviiyqekqgeeedaeiivkifvefsiasethka
iqalngrwfagrkvvaevydqerfdnsdlsa

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6lurC (C:)
mkhhhhhhpmsdkiihltddsfdtdvlkadgailvdfwaewcgpckmiapildeiadeyq
gkltvaklnidqnpgtapkygirgiptlllfkngevaatkvgalskgqlkefldanlags
amestvmvlrnmvdpkdidddlegevteecgkfgavnrviiyqekqgeeedaeiivkifv
efsiasethkaiqalngrwfagrkvvaevydqerfdnsdlsa

    Sequence, based on observed residues (ATOM records):
    >6lurC (C:)
dkiihltddsfdtdvlkadgailvdfwaewcgpckmiapildeiadeyqgkltvaklnid
qnpgtapkygirgiptlllfkngevaatkvgalskgqlkefldanlagsamestvmvlrn
mvdpkdidddlegevteecgkfgavnrviiyqekqgeeedaeiivkifvefsiasethka
iqalngrwfagrkvvaevydqerfdnsdlsa

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6lurD (D:)
mkhhhhhhpmsdkiihltddsfdtdvlkadgailvdfwaewcgpckmiapildeiadeyq
gkltvaklnidqnpgtapkygirgiptlllfkngevaatkvgalskgqlkefldanlags
amestvmvlrnmvdpkdidddlegevteecgkfgavnrviiyqekqgeeedaeiivkifv
efsiasethkaiqalngrwfagrkvvaevydqerfdnsdlsa

    Sequence, based on observed residues (ATOM records):
    >6lurD (D:)
msdkiihltddsfdtdvlkadgailvdfwaewcgpckmiapildeiadeyqgkltvakln
idqnpgtapkygirgiptlllfkngevaatkvgalskgqlkefldanlagsamestvmvl
rnmvdpkdidddlegevteecgkfgavnrviiyqekqgeeedaeiivkifvefsiaseth
kaiqalngrwfagrkvvaevydqerfdnsdlsa

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6lurE (E:)
mkhhhhhhpmsdkiihltddsfdtdvlkadgailvdfwaewcgpckmiapildeiadeyq
gkltvaklnidqnpgtapkygirgiptlllfkngevaatkvgalskgqlkefldanlags
amestvmvlrnmvdpkdidddlegevteecgkfgavnrviiyqekqgeeedaeiivkifv
efsiasethkaiqalngrwfagrkvvaevydqerfdnsdlsa

    Sequence, based on observed residues (ATOM records):
    >6lurE (E:)
dkiihltddsfdtdvlkadgailvdfwaewcgpckmiapildeiadeyqgkltvaklnid
qnpgtapkygirgiptlllfkngevaatkvgalskgqlkefldanlagsamestvmvlrn
mvdpkdidddlegevteecgkfgavnrviiyqekqgeeedaeiivkifvefsiasethka
iqalngrwfagrkvvaevydqerfdnsdlsa

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6lurF (F:)
mkhhhhhhpmsdkiihltddsfdtdvlkadgailvdfwaewcgpckmiapildeiadeyq
gkltvaklnidqnpgtapkygirgiptlllfkngevaatkvgalskgqlkefldanlags
amestvmvlrnmvdpkdidddlegevteecgkfgavnrviiyqekqgeeedaeiivkifv
efsiasethkaiqalngrwfagrkvvaevydqerfdnsdlsa

    Sequence, based on observed residues (ATOM records):
    >6lurF (F:)
dkiihltddsfdtdvlkadgailvdfwaewcgpckmiapildeiadeyqgkltvaklnid
qnpgtapkygirgiptlllfkngevaatkvgalskgqlkefldanlagsamestvmvlrn
mvdpkdidddlegevteecgkfgavnrviiyqekqgeeedaeiivkifvefsiasethka
iqalngrwfagrkvvaevydqerfdnsdlsa

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6lurG (G:)
mkhhhhhhpmsdkiihltddsfdtdvlkadgailvdfwaewcgpckmiapildeiadeyq
gkltvaklnidqnpgtapkygirgiptlllfkngevaatkvgalskgqlkefldanlags
amestvmvlrnmvdpkdidddlegevteecgkfgavnrviiyqekqgeeedaeiivkifv
efsiasethkaiqalngrwfagrkvvaevydqerfdnsdlsa

    Sequence, based on observed residues (ATOM records):
    >6lurG (G:)
dkiihltddsfdtdvlkadgailvdfwaewcgpckmiapildeiadeyqgkltvaklnid
qnpgtapkygirgiptlllfkngevaatkvgalskgqlkefldanlagsamestvmvlrn
mvdpkdidddlegevteecgkfgavnrviiyqekqgeeedaeiivkifvefsiasethka
iqalngrwfagrkvvaevydqerfdnsdlsa

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6lurH (H:)
mkhhhhhhpmsdkiihltddsfdtdvlkadgailvdfwaewcgpckmiapildeiadeyq
gkltvaklnidqnpgtapkygirgiptlllfkngevaatkvgalskgqlkefldanlags
amestvmvlrnmvdpkdidddlegevteecgkfgavnrviiyqekqgeeedaeiivkifv
efsiasethkaiqalngrwfagrkvvaevydqerfdnsdlsa

    Sequence, based on observed residues (ATOM records):
    >6lurH (H:)
dkiihltddsfdtdvlkadgailvdfwaewcgpckmiapildeiadeyqgkltvaklnid
qnpgtapkygirgiptlllfkngevaatkvgalskgqlkefldanlagsamestvmvlrn
mvdpkdidddlegevteecgkfgavnrviiyqekqgeeedaeiivkifvefsiasethka
iqalngrwfagrkvvaevydqerfdnsdlsa