PDB entry 6lub

View 6lub on RCSB PDB site
Description: Crystal Structure of EGFR(L858R/T790M/C797S) in complex with CH7233163
Class: transferase/transferase inhibitor
Keywords: protein kinase, inhibitor, transferase-transferase inhibitor complex, transferase
Deposited on 2020-01-27, released 2020-10-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-10-07, with a file datestamp of 2020-10-02.
Experiment type: XRAY
Resolution: 2.32 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • engineered mutation (96)
      • engineered mutation (103)
      • engineered mutation (164)
      • engineered mutation (171-173)
    Domains in SCOPe 2.08: d6luba_
  • Heterogens: EUX, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6lubA (A:)
gsgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatsp
kankeildeayvmasvdnphvcrllgicltstvqlimqlmpfgslldyvrehkdnigsqy
llnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgrakllgaaaaeyhaeg
gkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerl
pqppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpspt
dsnfyralmdeedmddvvdadeylipqqg

    Sequence, based on observed residues (ATOM records): (download) 
    >6lubA (A:)
geapnqallrilketefkkikvlgsgtvykglwipegekvkipvaiketspkankeilde
ayvmasvdnphvcrllgicltstvqlimqlmpfgslldyvrehkdnigsqyllnwcvqia
kgmnyledrrlvhrdlaarnvlvktpqhvkitdfgrakllgaaaaeyhaeggkvpikwma
lesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppictid
vymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpdmddvvdadeyl
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