PDB entry 6lt0

View 6lt0 on RCSB PDB site
Description: cryo-em structure of c9orf72-smcr8-wdr41
Deposited on 2020-01-21, released 2020-04-15
The last revision was dated 2020-05-27, with a file datestamp of 2020-05-22.
Experiment type: EM
Resolution: 3.2 Å
R-factor: N/A
AEROSPACI score: 0.12 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: WD repeat-containing protein 41
    Species: Homo sapiens [TaxId:9606]
    Gene: WDR41, MSTP048
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Guanine nucleotide exchange protein SMCR8
    Species: Homo sapiens [TaxId:9606]
    Gene: SMCR8
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Guanine nucleotide exchange C9orf72
    Species: Homo sapiens [TaxId:9606]
    Gene: C9orf72
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: WD repeat-containing protein 41
    Species: Homo sapiens [TaxId:9606]
    Gene: WDR41, MSTP048
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Guanine nucleotide exchange protein SMCR8
    Species: Homo sapiens [TaxId:9606]
    Gene: SMCR8
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Guanine nucleotide exchange C9orf72
    Species: Homo sapiens [TaxId:9606]
    Gene: C9orf72
    Database cross-references and differences (RAF-indexed):

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6lt0A (A:)
mlrwligggrepqglaeksplqtigeeqtqnpytellvlkahhdivrflvqlddyrfasa
gddgivvvwnaqtgekllelnghtqkitaiitfpslesceeknqliltasadrtvivwdg
dttrqvqriscfqstvkcltvlqrldvwlsggndlcvwnrkldllcktshlsdtgisalv
eipkncvvaavgkeliifrlvaptegslewdilevkrlldhqdnilslinvndlsfvtgs
hvgeliiwdaldwtmqayernfwdpspqldtqqeiklcqksndisihhftcdeenvfaav
grglyvyslqmkrviacqktahdsnvlhvarlpnrqliscsedgsvriwelrekqqlaae
pvptgffnmwgfgrvskqasqpvkkqqenatscsleligdlighsssvemflyfedhglv
tcsadhliilwkngeresglrslrlfqkleengdlylav

    Sequence, based on observed residues (ATOM records):
    >6lt0A (A:)
npytellvlkahhdivrflvqlddyrfasagddgivvvwnaqtgekllelnghtqkitai
itfpliltasadrtvivwdgdttrqvqriscfqstvkcltvlqrldvwlsggndlcvwnr
kldllcktshlsdtgisalveipkcvvaavgkeliifrlvapilevkrlldhqdnilsli
nvndlsfvtgshvgeliiwdadtqqeiklcqkisihhftcdeenvfaavgrglyvyslqm
krviacqktahdsnvlhvarlpnrqliscsedgsvriwelreligdlighsssvemflyf
edhglvtcsadhliilwkngeresglrslrlfqkleengdlyl

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6lt0B (B:)
misapdvvaftkeeeyeeepynepalpeeysvplfpfasqganpwsklsgakfsrdfili
sefseqvgpqplltipndtkvfgtfdlnyfslrimsvdyqasfvghppgsaypklnfved
skvvlgdskegafayvhhltlydleargfvrpfcmayisadqhkimqqfqelsaefsras
eclktgnrkafagelekklkdldytrtvlhteteiqkkandkgfyssqaiekanelasve
ksiiehqdllkqirsyphrklkghdlcpgemehiqdqasqasttsnpdesadtdlytcrp
aytpklikakstkcfdkklktleelcdteyftqtlaqlshiehmfrgdlcylltsqidra
llkqqhitnflfedfvevddrmvekqesipskpsqdrppsssleecpipkvlisvgsyks
svesvlikmeqelgdeeykevevtelssfdpqenldyldmdmkgsissgesievlgteks
tsvlsksdsqasltvplspqvvrskavshrtisedsievlstcpsealipddfkasypsa
ineeesypdgnegairfqasisppelgeteegsientpsqidssccigkesdgqlvlpst
pahthsdedgvvssppqrhrqkdqgfrvdfsvenanpssrdnscegfpayeldpshllas
rdisktsldnysdttsyvssvastssdripsaypaglssdrhkkragqnalkfirqypfa
hpaiysllsgrtlvvlgedeaivrklvtalaifvpsygcyakpvkhwassplhimdfqkw
kliglqrvaspagagtlhalsrysrytsildldnktlrcplyrgtlvprladhrtqikrg
styylhvqsmltqlcskaflytfchhlhlpthdketeelvasrqmsflkltlglvnedvr
vvqylaellklhymqespgtshpmlrfdyvpsflyki

    Sequence, based on observed residues (ATOM records):
    >6lt0B (B:)
filisefsdtkvfgtfdlnyfslrimsvdyqasfvghppgsypklnfvedskegafayvh
hltgfvrpfcmayisadqhkimqqfqelsaefsraseclktgnrkafateyftqtlaqls
hiehmfrgdlcylltsqidrallkqqhitnflfedrhkkragqnalkfirqypfahpaiy
sllsgrtlvvlgedeaivrklvtalaifvpsygcyakpvkhwassplhimdfqkwkligl
qrvagtlhalsrysrytsildldnktlrcplyrgtlvprladhrtqikrgstyylhvqsm
ltqlcskaflytfchhlhlpthdketeelvasrqmsflkltlglvnedvrvvqylaellk
lhymqespgtshpmlrfdyvpsflyk

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6lt0C (C:)
mstlcpppspavakteialsgkspllaatfaywdnilgprvrhiwapkteqvllsdgeit
flanhtlngeilrnaesgaidvkffvlsekgviivslifdgnwngdrstyglsiilpqte
lsfylplhrvcvdrlthiirkgriwmhkerqenvqkiilegtermedqgqsiipmltgev
ipvmellssmkshsvpeeidiadtvlndddigdschegfllnaisshlqtcgcsvvvgss
aekvnkivrtlclfltpaerkcsrlceaessfkyesglfvqgllkdstgsfvlpfrqvmy
apyptthidvdvntvkqmppchehiynqrrymrseltafwratseedmaqdtiiytdesf
tpdlnifqdvlhrdtlvkafldqvfqlkpglslrstflaqfllvlhrkaltlikyieddt
qkgkkpfkslrnlkidldltaegdlniimalaekikpglhsfifgrpfytsvqerdvlmt
f

    Sequence, based on observed residues (ATOM records):
    >6lt0C (C:)
akteialsgkspllaatfaywrvrhiwapkteqvllsdgeitflanhtlngeigaidvkf
fvlsekgviivsliftyglsiilpqtelsfylplhrvcvdrlthiirkgriwmhkeiipm
ltgevipvmellssmkshsvpeeidiadtvlndddigdschegfllnaisshlqtcgcsv
vvgssaekvnkivrtlclfltpaerkcsrlceaessfkyesglfvqgllkdstgsfvlpf
rqvmyapyptthidvdvntvkqmppchehiynqrrymrseltafwifqdvlhrdtlvkaf
ldqvfqlkpglslrstflaqfllvlhrkaltlikyieddtqkgkkpfkslrnlkidldlt
aegdlniimalaekikpglhsfifg

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6lt0D (D:)
mlrwligggrepqglaeksplqtigeeqtqnpytellvlkahhdivrflvqlddyrfasa
gddgivvvwnaqtgekllelnghtqkitaiitfpslesceeknqliltasadrtvivwdg
dttrqvqriscfqstvkcltvlqrldvwlsggndlcvwnrkldllcktshlsdtgisalv
eipkncvvaavgkeliifrlvaptegslewdilevkrlldhqdnilslinvndlsfvtgs
hvgeliiwdaldwtmqayernfwdpspqldtqqeiklcqksndisihhftcdeenvfaav
grglyvyslqmkrviacqktahdsnvlhvarlpnrqliscsedgsvriwelrekqqlaae
pvptgffnmwgfgrvskqasqpvkkqqenatscsleligdlighsssvemflyfedhglv
tcsadhliilwkngeresglrslrlfqkleengdlylav

    Sequence, based on observed residues (ATOM records):
    >6lt0D (D:)
npytellvlkahhdivrflvqlddyrfasagddgivvvwnaqtgekllelnghtqkitai
itfpliltasadrtvivwdgdttrqvqriscfqstvkcltvlqrldvwlsggndlcvwnr
kldllcktshlsdtgisalveipkcvvaavgkeliifrlvapilevkrlldhqdnilsli
nvndlsfvtgshvgeliiwdadtqqeiklcqkisihhftcdeenvfaavgrglyvyslqm
krviacqktahdsnvlhvarlpnrqliscsedgsvriwelreligdlighsssvemflyf
edhglvtcsadhliilwkngeresglrslrlfqkleengdlyl

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6lt0E (E:)
misapdvvaftkeeeyeeepynepalpeeysvplfpfasqganpwsklsgakfsrdfili
sefseqvgpqplltipndtkvfgtfdlnyfslrimsvdyqasfvghppgsaypklnfved
skvvlgdskegafayvhhltlydleargfvrpfcmayisadqhkimqqfqelsaefsras
eclktgnrkafagelekklkdldytrtvlhteteiqkkandkgfyssqaiekanelasve
ksiiehqdllkqirsyphrklkghdlcpgemehiqdqasqasttsnpdesadtdlytcrp
aytpklikakstkcfdkklktleelcdteyftqtlaqlshiehmfrgdlcylltsqidra
llkqqhitnflfedfvevddrmvekqesipskpsqdrppsssleecpipkvlisvgsyks
svesvlikmeqelgdeeykevevtelssfdpqenldyldmdmkgsissgesievlgteks
tsvlsksdsqasltvplspqvvrskavshrtisedsievlstcpsealipddfkasypsa
ineeesypdgnegairfqasisppelgeteegsientpsqidssccigkesdgqlvlpst
pahthsdedgvvssppqrhrqkdqgfrvdfsvenanpssrdnscegfpayeldpshllas
rdisktsldnysdttsyvssvastssdripsaypaglssdrhkkragqnalkfirqypfa
hpaiysllsgrtlvvlgedeaivrklvtalaifvpsygcyakpvkhwassplhimdfqkw
kliglqrvaspagagtlhalsrysrytsildldnktlrcplyrgtlvprladhrtqikrg
styylhvqsmltqlcskaflytfchhlhlpthdketeelvasrqmsflkltlglvnedvr
vvqylaellklhymqespgtshpmlrfdyvpsflyki

    Sequence, based on observed residues (ATOM records):
    >6lt0E (E:)
filisefsdtkvfgtfdlnyfslrimsvdyqasfvghppgsypklnfvedskegafayvh
hltgfvrpfcmayisadqhkimqqfqelsaefsraseclktgnrkafateyftqtlaqls
hiehmfrgdlcylltsqidrallkqqhitnflfedrhkkragqnalkfirqypfahpaiy
sllsgrtlvvlgedeaivrklvtalaifvpsygcyakpvkhwassplhimdfqkwkligl
qrvagtlhalsrysrytsildldnktlrcplyrgtlvprladhrtqikrgstyylhvqsm
ltqlcskaflytfchhlhlpthdketeelvasrqmsflkltlglvnedvrvvqylaellk
lhymqespgtshpmlrfdyvpsflyk

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6lt0F (F:)
mstlcpppspavakteialsgkspllaatfaywdnilgprvrhiwapkteqvllsdgeit
flanhtlngeilrnaesgaidvkffvlsekgviivslifdgnwngdrstyglsiilpqte
lsfylplhrvcvdrlthiirkgriwmhkerqenvqkiilegtermedqgqsiipmltgev
ipvmellssmkshsvpeeidiadtvlndddigdschegfllnaisshlqtcgcsvvvgss
aekvnkivrtlclfltpaerkcsrlceaessfkyesglfvqgllkdstgsfvlpfrqvmy
apyptthidvdvntvkqmppchehiynqrrymrseltafwratseedmaqdtiiytdesf
tpdlnifqdvlhrdtlvkafldqvfqlkpglslrstflaqfllvlhrkaltlikyieddt
qkgkkpfkslrnlkidldltaegdlniimalaekikpglhsfifgrpfytsvqerdvlmt
f

    Sequence, based on observed residues (ATOM records):
    >6lt0F (F:)
akteialsgkspllaatfaywrvrhiwapkteqvllsdgeitflanhtlngeigaidvkf
fvlsekgviivsliftyglsiilpqtelsfylplhrvcvdrlthiirkgriwmhkeiipm
ltgevipvmellssmkshsvpeeidiadtvlndddigdschegfllnaisshlqtcgcsv
vvgssaekvnkivrtlclfltpaerkcsrlceaessfkyesglfvqgllkdstgsfvlpf
rqvmyapyptthidvdvntvkqmppchehiynqrrymrseltafwifqdvlhrdtlvkaf
ldqvfqlkpglslrstflaqfllvlhrkaltlikyieddtqkgkkpfkslrnlkidldlt
aegdlniimalaekikpglhsfifg