PDB entry 6ls5

View 6ls5 on RCSB PDB site
Description: Structure of human liver FBPase complexed with covalent allosteric inhibitor
Class: hydrolase
Keywords: FBPase, HYDROLASE
Deposited on 2020-01-17, released 2020-05-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-06-24, with a file datestamp of 2020-06-19.
Experiment type: XRAY
Resolution: 2.03 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fructose-1,6-bisphosphatase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: FBP1, hCG_1640493
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6ls5a_
  • Chain 'B':
    Compound: Fructose-1,6-bisphosphatase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: FBP1, hCG_1640493
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6ls5b_
  • Chain 'C':
    Compound: Fructose-1,6-bisphosphatase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: FBP1, hCG_1640493
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6ls5c_
  • Chain 'D':
    Compound: Fructose-1,6-bisphosphatase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: FBP1, hCG_1640493
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6ls5d_
  • Heterogens: EUF, AMP, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6ls5A (A:)
msyyhhhhhhegvrtmadqapfdtdvntltrfvmeegrkargtgeltqllnslctavkai
ssavrkagiahlygiagstnvtgdqvkkldvlsndlvmnmlkssfatcvlvseedkhaii
vepekrgkyvvcfdpldgssnidclvsvgtifgiyrkkstdepsekdalqpgrnlvaagy
alygsatmlvlamdcgvncfmldpaigefilvdkdvkikkkgkiyslnegyakdfdpavt
eyiqrkkfppdnsapygaryvgsmvadvhrtlvyggiflypankkspngklrllyecnpm
ayvmekaggmattgkeavldviptdihqrapvilgspddvleflkvyekhsaq

    Sequence, based on observed residues (ATOM records): (download) 
    >6ls5A (A:)
dvntltrfvmeegrkargtgeltqllnslctavkaissavrkagiahlygiagstnvtgd
qvkkldvlsndlvmnmlkssfatcvlvseedkhaiivepekrgkyvvcfdpldgssnidc
lvsvgtifgiyrkkstdepsekdalqpgrnlvaagyalygsatmlvlamdcgvncfmldp
aigefilvdkdvkikkkgkiyslnegyakdfdpavteyiqrkkfppdnsapygaryvgsm
vadvhrtlvyggiflypankkspngklrllyecnpmayvmekaggmattgkeavldvipt
dihqrapvilgspddvleflkvyekhs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6ls5B (B:)
msyyhhhhhhegvrtmadqapfdtdvntltrfvmeegrkargtgeltqllnslctavkai
ssavrkagiahlygiagstnvtgdqvkkldvlsndlvmnmlkssfatcvlvseedkhaii
vepekrgkyvvcfdpldgssnidclvsvgtifgiyrkkstdepsekdalqpgrnlvaagy
alygsatmlvlamdcgvncfmldpaigefilvdkdvkikkkgkiyslnegyakdfdpavt
eyiqrkkfppdnsapygaryvgsmvadvhrtlvyggiflypankkspngklrllyecnpm
ayvmekaggmattgkeavldviptdihqrapvilgspddvleflkvyekhsaq

    Sequence, based on observed residues (ATOM records): (download) 
    >6ls5B (B:)
dvntltrfvmeegrkargtgeltqllnslctavkaissavrkagiahlygiagstdqvkk
ldvlsndlvmnmlkssfatcvlvseedkhaiivepekrgkyvvcfdpldgssnidclvsv
gtifgiyrkkstdepsekdalqpgrnlvaagyalygsatmlvlamdcgvncfmldpaige
filvdkdvkikkkgkiyslnegyakdfdpavteyiqrkkfppdnsapygaryvgsmvadv
hrtlvyggiflypankkspngklrllyecnpmayvmekaggmattgkeavldviptdihq
rapvilgspddvleflkvyekhs

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6ls5C (C:)
msyyhhhhhhegvrtmadqapfdtdvntltrfvmeegrkargtgeltqllnslctavkai
ssavrkagiahlygiagstnvtgdqvkkldvlsndlvmnmlkssfatcvlvseedkhaii
vepekrgkyvvcfdpldgssnidclvsvgtifgiyrkkstdepsekdalqpgrnlvaagy
alygsatmlvlamdcgvncfmldpaigefilvdkdvkikkkgkiyslnegyakdfdpavt
eyiqrkkfppdnsapygaryvgsmvadvhrtlvyggiflypankkspngklrllyecnpm
ayvmekaggmattgkeavldviptdihqrapvilgspddvleflkvyekhsaq

    Sequence, based on observed residues (ATOM records): (download) 
    >6ls5C (C:)
dvntltrfvmeegrkargtgeltqllnslctavkaissavrkagiahlygiagsvkkldv
lsndlvmnmlkssfatcvlvseedkhaiivepekrgkyvvcfdpldgssnidclvsvgti
fgiyrkkstdepsekdalqpgrnlvaagyalygsatmlvlamdcgvncfmldpaigefil
vdkdvkikkkgkiyslnegyakdfdpavteyiqrkkfppdnsapygaryvgsmvadvhrt
lvyggiflypankkspngklrllyecnpmayvmekaggmattgkeavldviptdihqrap
vilgspddvleflkvyekhs

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6ls5D (D:)
msyyhhhhhhegvrtmadqapfdtdvntltrfvmeegrkargtgeltqllnslctavkai
ssavrkagiahlygiagstnvtgdqvkkldvlsndlvmnmlkssfatcvlvseedkhaii
vepekrgkyvvcfdpldgssnidclvsvgtifgiyrkkstdepsekdalqpgrnlvaagy
alygsatmlvlamdcgvncfmldpaigefilvdkdvkikkkgkiyslnegyakdfdpavt
eyiqrkkfppdnsapygaryvgsmvadvhrtlvyggiflypankkspngklrllyecnpm
ayvmekaggmattgkeavldviptdihqrapvilgspddvleflkvyekhsaq

    Sequence, based on observed residues (ATOM records): (download) 
    >6ls5D (D:)
dvntltrfvmeegrkargtgeltqllnslctavkaissavrkagiahlygiagstnvtgd
qvkkldvlsndlvmnmlkssfatcvlvseedkhaiivepekrgkyvvcfdpldgssnidc
lvsvgtifgiyrkkstdepsekdalqpgrnlvaagyalygsatmlvlamdcgvncfmldp
aigefilvdkdvkikkkgkiyslnegyakdfdpavteyiqrkkfppdnsapygaryvgsm
vadvhrtlvyggiflypankkspngklrllyecnpmayvmekaggmattgkeavldvipt
dihqrapvilgspddvleflkvyekhs