PDB entry 6lrz

View 6lrz on RCSB PDB site
Description: Crystal structure of Keap1 in complex with dimethyl fumarate (DMF)
Class: cytosolic protein
Keywords: beta-propeller domain, oxidative stress, Keap1-Nrf2 system, DMF, inhibitor complex, CYTOSOLIC PROTEIN
Deposited on 2020-01-16, released 2020-08-05
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-08-05, with a file datestamp of 2020-07-31.
Experiment type: XRAY
Resolution: 1.54 Å
R-factor: N/A
AEROSPACI score: 0.55 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Keap1-DC
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6LRZ
    Domains in SCOPe 2.07: d6lrza1, d6lrza2
  • Heterogens: EOU, ACT, PG5, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6lrzA (A:)
mgsshhhhhhssglvprgshmvgrliytaggyfrqslsyleaynpsngswlrladlqvpr
sglagcvvggllyavggrnnspdgntdssaldcynpmtnqwspcasmsvprnrigvgvid
ghiyavggshgcihhssveryeperdewhlvapmltrrigvgvavlnrllyavggfdgtn
rlnsaecyypernewrmitpmntirsgagvcvlhnciyaaggydgqdqlnsverydvete
twtfvapmrhhrsalgitvhqgkiyvlggydghtfldsvecydpdsdtwsevtrmtsgrs
gvgvavtmepcrkq

    Sequence, based on observed residues (ATOM records): (download) 
    >6lrzA (A:)
rgshmvgrliytaggyfrqslsyleaynpsngswlrladlqvprsglagcvvggllyavg
grnnspdgntdssaldcynpmtnqwspcasmsvprnrigvgvidghiyavggshgcihhs
sveryeperdewhlvapmltrrigvgvavlnrllyavggfdgtnrlnsaecyypernewr
mitpmntirsgagvcvlhnciyaaggydgqdqlnsverydvetetwtfvapmrhhrsalg
itvhqgkiyvlggydghtfldsvecydpdsdtwsevtrmtsgrsgvgvavtmepc