PDB entry 6lrq

View 6lrq on RCSB PDB site
Description: cryo-em structure of a53t alpha-synuclein amyloid fibril
Deposited on 2020-01-16, released 2020-04-08
The last revision was dated 2020-04-15, with a file datestamp of 2020-04-10.
Experiment type: EM
Resolution: 3.49 Å
R-factor: N/A
AEROSPACI score: 0.06 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Alpha-synuclein
    Species: Homo sapiens [TaxId:9606]
    Gene: SNCA, NACP, PARK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P37840
      • engineered mutation (52)
  • Chain 'B':
    Compound: Alpha-synuclein
    Species: Homo sapiens [TaxId:9606]
    Gene: SNCA, NACP, PARK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P37840
      • engineered mutation (52)
  • Chain 'C':
    Compound: Alpha-synuclein
    Species: Homo sapiens [TaxId:9606]
    Gene: SNCA, NACP, PARK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P37840
      • engineered mutation (52)
  • Chain 'D':
    Compound: Alpha-synuclein
    Species: Homo sapiens [TaxId:9606]
    Gene: SNCA, NACP, PARK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P37840
      • engineered mutation (52)
  • Chain 'E':
    Compound: Alpha-synuclein
    Species: Homo sapiens [TaxId:9606]
    Gene: SNCA, NACP, PARK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P37840
      • engineered mutation (52)
  • Chain 'F':
    Compound: Alpha-synuclein
    Species: Homo sapiens [TaxId:9606]
    Gene: SNCA, NACP, PARK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P37840
      • engineered mutation (52)

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6lrqA (A:)
mdvfmkglskakegvvaaaektkqgvaeaagktkegvlyvgsktkegvvhgvttvaektk
eqvtnvggavvtgvtavaqktvegagsiaaatgfvkkdqlgkneegapqegiledmpvdp
dneayempseegyqdyepea

    Sequence, based on observed residues (ATOM records):
    >6lrqA (A:)
vlyvgsktkegvvhgvttvaektkeqvtnvggavvtgvtavaqktvegagsiaaatgfvk
kdq

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6lrqB (B:)
mdvfmkglskakegvvaaaektkqgvaeaagktkegvlyvgsktkegvvhgvttvaektk
eqvtnvggavvtgvtavaqktvegagsiaaatgfvkkdqlgkneegapqegiledmpvdp
dneayempseegyqdyepea

    Sequence, based on observed residues (ATOM records):
    >6lrqB (B:)
vlyvgsktkegvvhgvttvaektkeqvtnvggavvtgvtavaqktvegagsiaaatgfvk
kdq

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6lrqC (C:)
mdvfmkglskakegvvaaaektkqgvaeaagktkegvlyvgsktkegvvhgvttvaektk
eqvtnvggavvtgvtavaqktvegagsiaaatgfvkkdqlgkneegapqegiledmpvdp
dneayempseegyqdyepea

    Sequence, based on observed residues (ATOM records):
    >6lrqC (C:)
vlyvgsktkegvvhgvttvaektkeqvtnvggavvtgvtavaqktvegagsiaaatgfvk
kdq

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6lrqD (D:)
mdvfmkglskakegvvaaaektkqgvaeaagktkegvlyvgsktkegvvhgvttvaektk
eqvtnvggavvtgvtavaqktvegagsiaaatgfvkkdqlgkneegapqegiledmpvdp
dneayempseegyqdyepea

    Sequence, based on observed residues (ATOM records):
    >6lrqD (D:)
vlyvgsktkegvvhgvttvaektkeqvtnvggavvtgvtavaqktvegagsiaaatgfvk
kdq

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6lrqE (E:)
mdvfmkglskakegvvaaaektkqgvaeaagktkegvlyvgsktkegvvhgvttvaektk
eqvtnvggavvtgvtavaqktvegagsiaaatgfvkkdqlgkneegapqegiledmpvdp
dneayempseegyqdyepea

    Sequence, based on observed residues (ATOM records):
    >6lrqE (E:)
vlyvgsktkegvvhgvttvaektkeqvtnvggavvtgvtavaqktvegagsiaaatgfvk
kdq

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6lrqF (F:)
mdvfmkglskakegvvaaaektkqgvaeaagktkegvlyvgsktkegvvhgvttvaektk
eqvtnvggavvtgvtavaqktvegagsiaaatgfvkkdqlgkneegapqegiledmpvdp
dneayempseegyqdyepea

    Sequence, based on observed residues (ATOM records):
    >6lrqF (F:)
vlyvgsktkegvvhgvttvaektkeqvtnvggavvtgvtavaqktvegagsiaaatgfvk
kdq