PDB entry 6lpn

View 6lpn on RCSB PDB site
Description: crystal structure of human d-2-hydroxyglutarate dehydrogenase in apo form
Deposited on 2020-01-12, released 2021-01-13
The last revision was dated 2021-07-28, with a file datestamp of 2021-07-23.
Experiment type: XRAY
Resolution: 2.21 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: D-2-hydroxyglutarate dehydrogenase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: D2HGDH, D2HGD
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8N465 (4-474)
      • expression tag (0-3)
      • expression tag (475-480)
  • Chain 'B':
    Compound: D-2-hydroxyglutarate dehydrogenase, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: D2HGDH, D2HGD
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8N465 (4-474)
      • expression tag (0-3)
      • expression tag (475-480)
  • Heterogens: FAD, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6lpnA (A:)
gpgsrypvrrlpfstvskqdlaaferivpggvvtdpealqapnvdwlrtlrgcskvllrp
rtseevshilrhchernlavnpqggntgmvggsvpvfdeiilstarmnrvlsfhsvsgil
vcqagcvleelsryveerdfimpldlgakgschiggnvatnagglrflrygslhgtvlgl
evvladgtvldcltslrkdntgydlkqlfigsegtlgiittvsilcppkpravnvaflgc
pgfaevlqtfstckgmlgeilsafefmdavcmqlvgrhlhlaspvqespfyvlietsgsn
aghdaeklghflehalgsglvtdgtmatdqrkvkmlwalreritealsrdgyvykydlsl
pverlydivtdlrarlgphakhvvgyghlgdgnlhlnvtaeafspsllaalephvyewta
gqqgsvsaehgvgfrkrdvlgyskppgalqlmqqlkalldpkgilnpyktlpsqahhhhh
h

    Sequence, based on observed residues (ATOM records):
    >6lpnA (A:)
vrrlpfstvskqdlaaferivpggvvtdpealqapnvdwlrtlrgcskvllrprtseevs
hilrhchernlavnpqggntgmvggsvpvfdeiilstarmnrvlsfhsvsgilvcqagcv
leelsryveerdfimpldlgakgschiggnvatnagglrflrygslhgtvlglevvladg
tvldcltslrkdntgydlkqlfigsegtlgiittvsilcppkpravnvaflgcpgfaevl
qtfstckgmlgeilsafefmdavcmqlvgrhlhlaspvqespfyvlietsgsnaghdaek
lghflehalgsglvtdgtmatdqrkvkmlwalreritealsrdgyvykydlslpverlyd
ivtdlrarlgphakhvvgyghlgdgnlhlnvtaeafspsllaalephvyewtagqqgsvs
aehgvgfrkrdvlgyskppgalqlmqqlkalldpkgilnpyktlps

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6lpnB (B:)
gpgsrypvrrlpfstvskqdlaaferivpggvvtdpealqapnvdwlrtlrgcskvllrp
rtseevshilrhchernlavnpqggntgmvggsvpvfdeiilstarmnrvlsfhsvsgil
vcqagcvleelsryveerdfimpldlgakgschiggnvatnagglrflrygslhgtvlgl
evvladgtvldcltslrkdntgydlkqlfigsegtlgiittvsilcppkpravnvaflgc
pgfaevlqtfstckgmlgeilsafefmdavcmqlvgrhlhlaspvqespfyvlietsgsn
aghdaeklghflehalgsglvtdgtmatdqrkvkmlwalreritealsrdgyvykydlsl
pverlydivtdlrarlgphakhvvgyghlgdgnlhlnvtaeafspsllaalephvyewta
gqqgsvsaehgvgfrkrdvlgyskppgalqlmqqlkalldpkgilnpyktlpsqahhhhh
h

    Sequence, based on observed residues (ATOM records):
    >6lpnB (B:)
pvrrlpfstvskqdlaaferivpggvvtdpealqapnvdwlrtlrgcskvllrprtseev
shilrhchernlavnpqggntgmvggsvpvfdeiilstarmnrvlsfhsvsgilvcqagc
vleelsryveerdfimpldlgakgschiggnvatnagglrflrygslhgtvlglevvlad
gtvldcltslrkdntgydlkqlfigsegtlgiittvsilcppkpravnvaflgcpgfaev
lqtfstckgmlgeilsafefmdavcmqlvgrhlhlaspvqespfyvlietsgsnaghdae
klghflehalgsglvtdgtmatdqrkvkmlwalreritealsrdgyvykydlslpverly
divtdlrarlgphakhvvgyghlgdgnlhlnvtaeafspsllaalephvyewtagqqgsv
saehgvgfrkrdvlgyskppgalqlmqqlkalldpkgilnpyktlps