PDB entry 6lio

View 6lio on RCSB PDB site
Description: Crystal structure of human PDK2 complexed with GM67520
Class: transferase
Keywords: mitochondria, kinase, inhibitor, TRANSFERASE
Deposited on 2019-12-12, released 2020-09-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-09-30, with a file datestamp of 2020-09-25.
Experiment type: XRAY
Resolution: 1.76 Å
R-factor: N/A
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDK2, PDHK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6lioa1, d6lioa2
  • Chain 'B':
    Compound: [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDK2, PDHK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15119 (30-End)
      • expression tag (28-29)
    Domains in SCOPe 2.08: d6liob1, d6liob2, d6liob3
  • Heterogens: EH3, GOL, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >6lioA (A:)
    magshhhhhhgmasmtggqqmgrsgddddkallknaslagapkyiehfskfspsplsmkq
    fldfgssnacektsftflrqelpvrlanimkeinllpdrvlstpsvqlvqswyvqslldi
    mefldkdpedhrtlsqftdalvtirnrhndvvptmaqgvleykdtygddpvsnqniqyfl
    drfylsrisirmlinqhtlifdgstnpahpkhigsidpncnvsevvkdaydmakllcdky
    ymaspdleiqeinaanskqpihmvyvpshlyhmlfelfknamratveshesslilppikv
    mvalgeedlsikmsdrgggvplrkierlfsymystaptpqpgtggtplagfgyglpisrl
    yakyfqgdlqlfsmegfgtdaviylkalstdsverlpvynksawrhyqtiq
    

    Sequence, based on observed residues (ATOM records): (download)
    >6lioA (A:)
    agapkyiehfskfspsplsmkqfldfgssnacektsftflrqelpvrlanimkeinllpd
    rvlstpsvqlvqswyvqslldimefldkdpedhrtlsqftdalvtirnrhndvvptmaqg
    vleykdtygddpvsnqniqyfldrfylsrisirmlinqhtlifdgstnpahpkhigsidp
    ncnvsevvkdaydmakllcdkyymaspdleiqeinaanskqpihmvyvpshlyhmlfelf
    knamratveshesslilppikvmvalgeedlsikmsdrgggvplrkierlfsymysgfgy
    glpisrlyakyfqgdlqlfsmegfgtdaviylkalstdsverlpvynksawrhy
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >6lioB (B:)
    magshhhhhhgmasmtggqqmgrsgddddkallknaslagapkyiehfskfspsplsmkq
    fldfgssnacektsftflrqelpvrlanimkeinllpdrvlstpsvqlvqswyvqslldi
    mefldkdpedhrtlsqftdalvtirnrhndvvptmaqgvleykdtygddpvsnqniqyfl
    drfylsrisirmlinqhtlifdgstnpahpkhigsidpncnvsevvkdaydmakllcdky
    ymaspdleiqeinaanskqpihmvyvpshlyhmlfelfknamratveshesslilppikv
    mvalgeedlsikmsdrgggvplrkierlfsymystaptpqpgtggtplagfgyglpisrl
    yakyfqgdlqlfsmegfgtdaviylkalstdsverlpvynksawrhyqtiq
    

    Sequence, based on observed residues (ATOM records): (download)
    >6lioB (B:)
    dkallknaslagapkyiehfskfspsplsmkqfldfgssnacektsftflrqelpvrlan
    imkeinllpdrvlstpsvqlvqswyvqslldimefldkdpedhrtlsqftdalvtirnrh
    ndvvptmaqgvleykdtygddpvsnqniqyfldrfylsrisirmlinqhtlifdgstnpa
    hpkhigsidpncnvsevvkdaydmakllcdkyymaspdleiqeinaanskqpihmvyvps
    hlyhmlfelfknamratveshesslilppikvmvalgeedlsikmsdrgggvplrkierl
    fsymysttplagfgyglpisrlyakyfqgdlqlfsmegfgtdaviylkalstdsverlpv
    ynksawrhyqt