PDB entry 6lin

View 6lin on RCSB PDB site
Description: Crystal structure of human PDK2 complexed with GM10030
Class: transferase
Keywords: mitochondria, kinase, inhibitor, TRANSFERASE
Deposited on 2019-12-12, released 2020-09-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-09-30, with a file datestamp of 2020-09-25.
Experiment type: XRAY
Resolution: 2.67 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDK2, PDHK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15119 (30-End)
      • expression tag (28-29)
    Domains in SCOPe 2.08: d6lina1, d6lina2, d6lina3
  • Chain 'B':
    Compound: [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDK2, PDHK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6linb1, d6linb2
  • Chain 'C':
    Compound: [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDK2, PDHK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15119 (30-End)
      • expression tag (27-29)
    Domains in SCOPe 2.08: d6linc1, d6linc2, d6linc3
  • Chain 'D':
    Compound: [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDK2, PDHK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6lind1, d6lind2
  • Heterogens: EH0, SO4, GOL, PEG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6linA (A:)
magshhhhhhgmasmtggqqmgrsgddddkallknaslagapkyiehfskfspsplsmkq
fldfgssnacektsftflrqelpvrlanimkeinllpdrvlstpsvqlvqswyvqslldi
mefldkdpedhrtlsqftdalvtirnrhndvvptmaqgvleykdtygddpvsnqniqyfl
drfylsrisirmlinqhtlifdgstnpahpkhigsidpncnvsevvkdaydmakllcdky
ymaspdleiqeinaanskqpihmvyvpshlyhmlfelfknamratveshesslilppikv
mvalgeedlsikmsdrgggvplrkierlfsymystaptpqpgtggtplagfgyglpisrl
yakyfqgdlqlfsmegfgtdaviylkalstdsverlpvynksawrhyqtiq

    Sequence, based on observed residues (ATOM records): (download) 
    >6linA (A:)
dkallknaslagapkyiehfskfspsplsmkqfldfgssnacektsftflrqelpvrlan
imkeinllpdrvlstpsvqlvqswyvqslldimefldkdpedhrtlsqftdalvtirnrh
ndvvptmaqgvleykdtygddpvsnqniqyfldrfylsrisirmlinqhtlifdgstnpa
hpkhigsidpncnvsevvkdaydmakllcdkyymaspdleiqeinaanskqpihmvyvps
hlyhmlfelfknamratveshesslilppikvmvalgeedlsikmsdrgggvplrkierl
fsymyfgyglpisrlyakyfqgdlqlfsmegfgtdaviylkalstdsverlpvynksawr
hyqti

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6linB (B:)
magshhhhhhgmasmtggqqmgrsgddddkallknaslagapkyiehfskfspsplsmkq
fldfgssnacektsftflrqelpvrlanimkeinllpdrvlstpsvqlvqswyvqslldi
mefldkdpedhrtlsqftdalvtirnrhndvvptmaqgvleykdtygddpvsnqniqyfl
drfylsrisirmlinqhtlifdgstnpahpkhigsidpncnvsevvkdaydmakllcdky
ymaspdleiqeinaanskqpihmvyvpshlyhmlfelfknamratveshesslilppikv
mvalgeedlsikmsdrgggvplrkierlfsymystaptpqpgtggtplagfgyglpisrl
yakyfqgdlqlfsmegfgtdaviylkalstdsverlpvynksawrhyqtiq

    Sequence, based on observed residues (ATOM records): (download) 
    >6linB (B:)
lagapkyiehfskfspsplsmkqfldfgssnacektsftflrqelpvrlanimkeinllp
drvlstpsvqlvqswyvqslldimefldkdpedhrtlsqftdalvtirnrhndvvptmaq
gvleykdtygddpvsnqniqyfldrfylsrisirmlinqhtlifdgstnpahpkhigsid
pncnvsevvkdaydmakllcdkyymaspdleiqeinaanskqpihmvyvpshlyhmlfel
fknamratveshesslilppikvmvalgeedlsikmsdrgggvplrkierlfsymystap
agfgyglpisrlyakyfqgdlqlfsmegfgtdaviylkalstdsverlpvynksawrhyq
ti

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6linC (C:)
magshhhhhhgmasmtggqqmgrsgddddkallknaslagapkyiehfskfspsplsmkq
fldfgssnacektsftflrqelpvrlanimkeinllpdrvlstpsvqlvqswyvqslldi
mefldkdpedhrtlsqftdalvtirnrhndvvptmaqgvleykdtygddpvsnqniqyfl
drfylsrisirmlinqhtlifdgstnpahpkhigsidpncnvsevvkdaydmakllcdky
ymaspdleiqeinaanskqpihmvyvpshlyhmlfelfknamratveshesslilppikv
mvalgeedlsikmsdrgggvplrkierlfsymystaptpqpgtggtplagfgyglpisrl
yakyfqgdlqlfsmegfgtdaviylkalstdsverlpvynksawrhyqtiq

    Sequence, based on observed residues (ATOM records): (download) 
    >6linC (C:)
ddkallknaslagapkyiehfskfspsplsmkqfldfgssnacektsftflrqelpvrla
nimkeinllpdrvlstpsvqlvqswyvqslldimefldkdpedhrtlsqftdalvtirnr
hndvvptmaqgvleykdtygddpvsnqniqyfldrfylsrisirmlinqhtlifdgstnp
ahpkhigsidpncnvsevvkdaydmakllcdkyymaspdleiqeinaanskqpihmvyvp
shlyhmlfelfknamratveshesslilppikvmvalgeedlsikmsdrgggvplrkier
lfsymysgfgyglpisrlyakyfqgdlqlfsmegfgtdaviylkalstdsverlpvynks
awrhyqt

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6linD (D:)
magshhhhhhgmasmtggqqmgrsgddddkallknaslagapkyiehfskfspsplsmkq
fldfgssnacektsftflrqelpvrlanimkeinllpdrvlstpsvqlvqswyvqslldi
mefldkdpedhrtlsqftdalvtirnrhndvvptmaqgvleykdtygddpvsnqniqyfl
drfylsrisirmlinqhtlifdgstnpahpkhigsidpncnvsevvkdaydmakllcdky
ymaspdleiqeinaanskqpihmvyvpshlyhmlfelfknamratveshesslilppikv
mvalgeedlsikmsdrgggvplrkierlfsymystaptpqpgtggtplagfgyglpisrl
yakyfqgdlqlfsmegfgtdaviylkalstdsverlpvynksawrhyqtiq

    Sequence, based on observed residues (ATOM records): (download) 
    >6linD (D:)
lagapkyiehfskfspsplsmkqfldfgssnacektsftflrqelpvrlanimkeinllp
drvlstpsvqlvqswyvqslldimefldkdpedhrtlsqftdalvtirnrhndvvptmaq
gvleykdtygddpvsnqniqyfldrfylsrisirmlinqhtlifdgstnpahpkhigsid
pncnvsevvkdaydmakllcdkyymaspdleiqeinaanskqpihmvyvpshlyhmlfel
fknamratveshesslilppikvmvalgeedlsikmsdrgggvplrkierlfsymysfgy
glpisrlyakyfqgdlqlfsmegfgtdaviylkalstdsverlpvynksawrhy