PDB entry 6lil

View 6lil on RCSB PDB site
Description: Crystal structure of human PDK2 complexed with an allosteric inhibitor compound 8c
Class: transferase
Keywords: mitochondria, kinase, inhibitor, TRANSFERASE
Deposited on 2019-12-12, released 2020-09-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-09-30, with a file datestamp of 2020-09-25.
Experiment type: XRAY
Resolution: 1.93 Å
R-factor: N/A
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDK2, PDHK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6lila1, d6lila2
  • Chain 'B':
    Compound: [pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: PDK2, PDHK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6lilb1, d6lilb2
  • Heterogens: EGX, FLC, PEG, GOL, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6lilA (A:)
magshhhhhhgmasmtggqqmgrsgddddkallknaslagapkyiehfskfspsplsmkq
fldfgssnacektsftflrqelpvrlanimkeinllpdrvlstpsvqlvqswyvqslldi
mefldkdpedhrtlsqftdalvtirnrhndvvptmaqgvleykdtygddpvsnqniqyfl
drfylsrisirmlinqhtlifdgstnpahpkhigsidpncnvsevvkdaydmakllcdky
ymaspdleiqeinaanskqpihmvyvpshlyhmlfelfknamratveshesslilppikv
mvalgeedlsikmsdrgggvplrkierlfsymystaptpqpgtggtplagfgyglpisrl
yakyfqgdlqlfsmegfgtdaviylkalstdsverlpvynksawrhyqtiq

    Sequence, based on observed residues (ATOM records): (download) 
    >6lilA (A:)
gapkyiehfskfspsplsmkqfldfgssnacektsftflrqelpvrlanimkeinllpdr
vlstpsvqlvqswyvqslldimefldkdpedhrtlsqftdalvtirnrhndvvptmaqgv
leykdtygddpvsnqniqyfldrfylsrisirmlinqhtlifdghpkhigsidpncnvse
vvkdaydmakllcdkyymaspdleiqeinaanskqpihmvyvpshlyhmlfelfknamra
tveshesslilppikvmvalgeedlsikmsdrgggvplrkierlfsymystagtplagfg
yglpisrlyakyfqgdlqlfsmegfgtdaviylkalstdsverlpv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6lilB (B:)
magshhhhhhgmasmtggqqmgrsgddddkallknaslagapkyiehfskfspsplsmkq
fldfgssnacektsftflrqelpvrlanimkeinllpdrvlstpsvqlvqswyvqslldi
mefldkdpedhrtlsqftdalvtirnrhndvvptmaqgvleykdtygddpvsnqniqyfl
drfylsrisirmlinqhtlifdgstnpahpkhigsidpncnvsevvkdaydmakllcdky
ymaspdleiqeinaanskqpihmvyvpshlyhmlfelfknamratveshesslilppikv
mvalgeedlsikmsdrgggvplrkierlfsymystaptpqpgtggtplagfgyglpisrl
yakyfqgdlqlfsmegfgtdaviylkalstdsverlpvynksawrhyqtiq

    Sequence, based on observed residues (ATOM records): (download) 
    >6lilB (B:)
apkyiehfskfspsplsmkqfldfgssnacektsftflrqelpvrlanimkeinllpdrv
lstpsvqlvqswyvqslldimefldkdpedhrtlsqftdalvtirnrhndvvptmaqgvl
eykdtygddpvsnqniqyfldrfylsrisirmlinqhtlifdhpkhigsidpncnvsevv
kdaydmakllcdkyymaspdleiqeinaanskqpihmvyvpshlyhmlfelfknamratv
eshesslilppikvmvalgeedlsikmsdrgggvplrkierlfsymystagtplagfgyg
lpisrlyakyfqgdlqlfsmegfgtdaviylkalstdsverlpv