PDB entry 6lg9

View 6lg9 on RCSB PDB site
Description: crystal structure of the first bromodomain of human BRD4 in complex with compound BDF-2143
Class: transcription
Keywords: BRD4, Inhibitor, Complex, DNA BINDING PROTEIN, TRANSCRIPTION
Deposited on 2019-12-04, released 2020-12-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-12-09, with a file datestamp of 2020-12-04.
Experiment type: XRAY
Resolution: 1.81 Å
R-factor: N/A
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bromodomain-containing protein 4
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD4, HUNK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60885 (1-End)
      • expression tag (0)
    Domains in SCOPe 2.08: d6lg9a1, d6lg9a2
  • Heterogens: ECU, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6lg9A (A:)
mnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykiik
tpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqkin
elpte

    Sequence, based on observed residues (ATOM records): (download) 
    >6lg9A (A:)
mnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykiik
tpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqkin
elpt