PDB entry 6lez

View 6lez on RCSB PDB site
Description: quadruple mutant (n51i+c59r+s108n+i164l) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with compound 46 and nadph
Deposited on 2019-11-27, released 2020-12-02
The last revision was dated 2020-12-02, with a file datestamp of 2020-11-27.
Experiment type: XRAY
Resolution: 2.64 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bifunctional dihydrofolate reductase-thymidylate synthase
    Species: Plasmodium falciparum [TaxId:5833]
    Gene: DHFR-TS, V1/S
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Bifunctional dihydrofolate reductase-thymidylate synthase
    Species: Plasmodium falciparum [TaxId:5833]
    Gene: DHFR-TS, V1/S
    Database cross-references and differences (RAF-indexed):
  • Heterogens: EA0, NDP, PO4, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6lezA (A:)
mmeqvcdvfdiyaicacckvesknegkknevfnnytfrglgnkgvlpwkcisldmkyfra
vttyvneskyeklkykrckylnketvdnvndmpnskklqnvvvmgrtnwesipkkfkpls
nrinvilsrtlkkedfdedvyiinkvedlivllgklnyykcfilggsvvyqeflekklik
kiyftrinstyecdvffpeineneyqiisvsdvytsnnttldfiiykktnnkmlneqnci
kgeeknndmplknddkdtchmkkltefyknvdkykinyenddddeeeddfvyfnfnkeke
eknknsihpndfqiynslkykyhpeyqylniiydimmngnkqsdrtgvgvlskfgyimkf
dlsqyfpllttkklflrgiieellwfirgetngntllnknvriweangtrefldnrklfh
revndlgpiygfqwrhfgaeytnmydnyenkgvdqlkniinlikndptsrrillcawnvk
dldqmalppchilcqfyvfdgklscimyqrscdlglgvpfniasysifthmiaqvcnlqp
aqfihvlgnahvynnhidslkiqlnripypfptlklnpdikniedftisdftiqnyvhhe
kismdmaa

    Sequence, based on observed residues (ATOM records):
    >6lezA (A:)
qvcdvfdiyaicacckvesnevfnnytfrglgnkgvlpwkcisldmkyfravttyvnesk
yeklkykrckylnkklqnvvvmgrtnwesipkkfkplsnrinvilsrtlkkedfdedvyi
inkvedlivllgklnyykcfilggsvvyqeflekklikkiyftrinstyecdvffpeine
neyqiisvsdvytsnnttldfiiykktnddeeeddfvyfnfnkeknknsihpndfqiyns
lkykyhpeyqylniiydimmngnkqsdrtgvgvlskfgyimkfdlsqyfpllttkklflr
giieellwfirgetngntllnknvriweangtrefldnrklfhrevndlgpiygfqwrhf
gaeytnmydnyenkgvdqlkniinlikndptsrrillcawnvkdldqmalppchilcqfy
vfdgklscimyqrscdlglgvpfniasysifthmiaqvcnlqpaqfihvlgnahvynnhi
dslkiqlnripypfptlklnpdikniedftisdftiqnyvhhekismd

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6lezB (B:)
mmeqvcdvfdiyaicacckvesknegkknevfnnytfrglgnkgvlpwkcisldmkyfra
vttyvneskyeklkykrckylnketvdnvndmpnskklqnvvvmgrtnwesipkkfkpls
nrinvilsrtlkkedfdedvyiinkvedlivllgklnyykcfilggsvvyqeflekklik
kiyftrinstyecdvffpeineneyqiisvsdvytsnnttldfiiykktnnkmlneqnci
kgeeknndmplknddkdtchmkkltefyknvdkykinyenddddeeeddfvyfnfnkeke
eknknsihpndfqiynslkykyhpeyqylniiydimmngnkqsdrtgvgvlskfgyimkf
dlsqyfpllttkklflrgiieellwfirgetngntllnknvriweangtrefldnrklfh
revndlgpiygfqwrhfgaeytnmydnyenkgvdqlkniinlikndptsrrillcawnvk
dldqmalppchilcqfyvfdgklscimyqrscdlglgvpfniasysifthmiaqvcnlqp
aqfihvlgnahvynnhidslkiqlnripypfptlklnpdikniedftisdftiqnyvhhe
kismdmaa

    Sequence, based on observed residues (ATOM records):
    >6lezB (B:)
qvcdvfdiyaicacckvenevfnnytfrglgnkgvlpwkcisldmkyfravttyvnesky
eklkykrckylqnvvvmgrtnwesipkkfkplsnrinvilsrtlkkedfdedvyiinkve
dlivllgklnyykcfilggsvvyqeflekklikkiyftrinstyecdvffpeineneyqi
isvsdvytsnnttldfiiykktnddeeeddfvyfnfnkenknsihpndfqiynslkykyh
peyqylniiydimmngnkqsdrtgvgvlskfgyimkfdlsqyfpllttkklflrgiieel
lwfirgetngntllnknvriweangtrefldnrklfhrevndlgpiygfqwrhfgaeytn
mydnyenkgvdqlkniinlikndptsrrillcawnvkdldqmalppchilcqfyvfdgkl
scimyqrscdlglgvpfniasysifthmiaqvcnlqpaqfihvlgnahvynnhidslkiq
lnripypfptlklnpdikniedftisdftiqnyvhhekismd