PDB entry 6lca

View 6lca on RCSB PDB site
Description: Crystal structure of human Dishevelled1 PDZ domain homotrimer
Class: signaling protein
Keywords: Wnt signaling pathway, Signaling protein, Developmental protein, PROTEIN BINDING, Dvl
Deposited on 2019-11-18, released 2020-11-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-11-25, with a file datestamp of 2020-11-20.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Segment polarity protein dishevelled homolog DVL-1
    Species: Homo sapiens [TaxId:9606]
    Gene: DVL1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O14640
      • engineered mutation (99)
    Domains in SCOPe 2.08: d6lcaa_
  • Chain 'B':
    Compound: Segment polarity protein dishevelled homolog DVL-1
    Species: Homo sapiens [TaxId:9606]
    Gene: DVL1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6lcab_
  • Chain 'C':
    Compound: Segment polarity protein dishevelled homolog DVL-1
    Species: Homo sapiens [TaxId:9606]
    Gene: DVL1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O14640
      • engineered mutation (99)
    Domains in SCOPe 2.08: d6lcac_
  • Chain 'D':
    Compound: Segment polarity protein dishevelled homolog DVL-1
    Species: Homo sapiens [TaxId:9606]
    Gene: DVL1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O14640
      • engineered mutation (99)
    Domains in SCOPe 2.08: d6lcad_
  • Chain 'E':
    Compound: Segment polarity protein dishevelled homolog DVL-1
    Species: Homo sapiens [TaxId:9606]
    Gene: DVL1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O14640
      • engineered mutation (99)
    Domains in SCOPe 2.08: d6lcae_
  • Chain 'F':
    Compound: Segment polarity protein dishevelled homolog DVL-1
    Species: Homo sapiens [TaxId:9606]
    Gene: DVL1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O14640
      • engineered mutation (99)
    Domains in SCOPe 2.08: d6lcaf_
  • Chain 'G':
    Compound: Segment polarity protein dishevelled homolog DVL-1
    Species: Homo sapiens [TaxId:9606]
    Gene: DVL1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O14640
      • engineered mutation (99)
    Domains in SCOPe 2.08: d6lcag_
  • Chain 'H':
    Compound: Segment polarity protein dishevelled homolog DVL-1
    Species: Homo sapiens [TaxId:9606]
    Gene: DVL1
    Database cross-references and differences (RAF-indexed):
    • Uniprot O14640
      • engineered mutation (99)
    Domains in SCOPe 2.08: d6lcah_
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6lcaA (A:)
gplgsdhslnivtvtlnmerhhflgisivgqsndrgdggiyigsimkggavaadgriepg
dmllqvndvnfenmsnddavrvlreivsqtgpisltvakatd

    Sequence, based on observed residues (ATOM records): (download) 
    >6lcaA (A:)
nivtvtlnmerhhflgisivgqsdgiyigsimkggavaadgriepgdmllqvndvnfenm
snddavrvlreivsqtgpisltvaka

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6lcaB (B:)
gplgsdhslnivtvtlnmerhhflgisivgqsndrgdggiyigsimkggavaadgriepg
dmllqvndvnfenmsnddavrvlreivsqtgpisltvakatd

    Sequence, based on observed residues (ATOM records): (download) 
    >6lcaB (B:)
nivtvtlnmerhhflgisivgqsndrgdggiyigsimkggavaadgriepgdmllqvndv
nfenmsnddavrvlreivsqtgpisltvak

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6lcaC (C:)
gplgsdhslnivtvtlnmerhhflgisivgqsndrgdggiyigsimkggavaadgriepg
dmllqvndvnfenmsnddavrvlreivsqtgpisltvakatd

    Sequence, based on observed residues (ATOM records): (download) 
    >6lcaC (C:)
nivtvtlnmerhhflgisivgqsndrgdggiyigsimkggavaadgriepgdmllqvndv
nfenmsnddavrvlreivsqtgpisltvaka

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6lcaD (D:)
gplgsdhslnivtvtlnmerhhflgisivgqsndrgdggiyigsimkggavaadgriepg
dmllqvndvnfenmsnddavrvlreivsqtgpisltvakatd

    Sequence, based on observed residues (ATOM records): (download) 
    >6lcaD (D:)
nivtvtlnmerhhflgisivgqsndrgdggiyigsimkggavaadgriepgdmllqvndv
nfenmsnddavrvlreivsqtgpisltvaka

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6lcaE (E:)
gplgsdhslnivtvtlnmerhhflgisivgqsndrgdggiyigsimkggavaadgriepg
dmllqvndvnfenmsnddavrvlreivsqtgpisltvakatd

    Sequence, based on observed residues (ATOM records): (download) 
    >6lcaE (E:)
nivtvtlnmerhhflgisivgqsndrgdggiyigsimkggavaadgriepgdmllqvndv
nfenmsnddavrvlreivsqtgpisltvaka

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6lcaF (F:)
gplgsdhslnivtvtlnmerhhflgisivgqsndrgdggiyigsimkggavaadgriepg
dmllqvndvnfenmsnddavrvlreivsqtgpisltvakatd

    Sequence, based on observed residues (ATOM records): (download) 
    >6lcaF (F:)
nivtvtlnmerhhflgisivgqsndrgdggiyigsimkggavaadgriepgdmllqvndv
nfenmsnddavrvlreivsqtgpisltvaka

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >6lcaG (G:)
gplgsdhslnivtvtlnmerhhflgisivgqsndrgdggiyigsimkggavaadgriepg
dmllqvndvnfenmsnddavrvlreivsqtgpisltvakatd

    Sequence, based on observed residues (ATOM records): (download) 
    >6lcaG (G:)
nivtvtlnmerhhflgisivgqsndrgdggiyigsimkggavaadgriepgdmllqvndv
nfenmsnddavrvlreivsqtgpisltvaka

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6lcaH (H:)
gplgsdhslnivtvtlnmerhhflgisivgqsndrgdggiyigsimkggavaadgriepg
dmllqvndvnfenmsnddavrvlreivsqtgpisltvakatd

    Sequence, based on observed residues (ATOM records): (download) 
    >6lcaH (H:)
nivtvtlnmerhhflgisivgqsndrgdggiyigsimkggavaadgriepgdmllqvndv
nfenmsnddavrvlreivsqtgpisltvaka