PDB entry 6l8l

View 6l8l on RCSB PDB site
Description: C-Src in complex with ibrutinib
Class: transferase
Keywords: kinase, TRANSFERASE
Deposited on 2019-11-06, released 2020-11-11
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-11-11, with a file datestamp of 2020-11-06.
Experiment type: XRAY
Resolution: 2.89 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Proto-oncogene tyrosine-protein kinase Src
    Species: Gallus gallus [TaxId:9031]
    Gene: SRC
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6l8la_
  • Chain 'B':
    Compound: Proto-oncogene tyrosine-protein kinase Src
    Species: Gallus gallus [TaxId:9031]
    Gene: SRC
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6l8lb_
  • Chain 'C':
    Compound: Proto-oncogene tyrosine-protein kinase Src
    Species: Gallus gallus [TaxId:9031]
    Gene: SRC
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6l8lc_
  • Chain 'D':
    Compound: Proto-oncogene tyrosine-protein kinase Src
    Species: Gallus gallus [TaxId:9031]
    Gene: SRC
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6l8ld_
  • Heterogens: 1E8, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6l8lA (A:)
ghmqtqglakdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaf
lqeaqvmkklrheklvqlyavvseepiyivteymskgslldflkgemgkylrlpqlvdma
aqiasgmayvermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpik
wtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppec
peslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpgenl

    Sequence, based on observed residues (ATOM records): (download) 
    >6l8lA (A:)
eipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaflqeaqvmkklrhe
klvqlyavvsepiyivteymskgslldflkgemgkylrlpqlvdmaaqiasgmayvermn
yvhrdlraanilvgenlvckvadfglarfpikwtapeaalygrftiksdvwsfgilltel
ttkgrvpypgmvnrevldqvergyrmpcppecpeslhdlmcqcwrkdpeerptfeylqaf
ledyftstepqyqpgenl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6l8lB (B:)
ghmqtqglakdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaf
lqeaqvmkklrheklvqlyavvseepiyivteymskgslldflkgemgkylrlpqlvdma
aqiasgmayvermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpik
wtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppec
peslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpgenl

    Sequence, based on observed residues (ATOM records): (download) 
    >6l8lB (B:)
preslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaflqeaqvmkklrhekl
vqlyavvseepiyivteymskgslldflkgemgkylrlpqlvdmaaqiasgmayvermny
vhrdlraanilvgenlvckvadfglafpikwtapeaalygrftiksdvwsfgillteltt
kgrvpypgmvnrevldqvergyrmpcppecpeslhdlmcqcwrkdpeerptfeylqafle
dyftstepqyqpgenl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6l8lC (C:)
ghmqtqglakdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaf
lqeaqvmkklrheklvqlyavvseepiyivteymskgslldflkgemgkylrlpqlvdma
aqiasgmayvermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpik
wtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppec
peslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpgenl

    Sequence, based on observed residues (ATOM records): (download) 
    >6l8lC (C:)
eipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaflqeaqvmkklrhe
klvqlyavvseepiyivteymskgslldflkgemgkylrlpqlvdmaaqiasgmayverm
nyvhrdlraanilvgenlvckvadfglafpikwtapeaalygrftiksdvwsfgilltel
ttkgrvpypgmvnrevldqvergyrmpcppecpeslhdlmcqcwrkdpeerptfeylqaf
ledyftstepqyqpgenl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6l8lD (D:)
ghmqtqglakdaweipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaf
lqeaqvmkklrheklvqlyavvseepiyivteymskgslldflkgemgkylrlpqlvdma
aqiasgmayvermnyvhrdlraanilvgenlvckvadfglarliedneytarqgakfpik
wtapeaalygrftiksdvwsfgilltelttkgrvpypgmvnrevldqvergyrmpcppec
peslhdlmcqcwrkdpeerptfeylqafledyftstepqyqpgenl

    Sequence, based on observed residues (ATOM records): (download) 
    >6l8lD (D:)
ipreslrlevklgqgcfgevwmgtwngttrvaiktlkpgtmspeaflqeaqvmkklrhek
lvqlyavvsepiyivteymskgslldflkgemgkylrlpqlvdmaaqiasgmayvermny
vhrdlraanilvgenlvckvadfglafpikwtapeaalygrftiksdvwsfgillteltt
kgrvpypgmvnrevldqvergyrmpcppecpeslhdlmcqcwrkdpeerptfeylqafle
dyftstepqyqpgenl