PDB entry 6l6r

View 6l6r on RCSB PDB site
Description: crystal structure of lrp6 e1e2-sost complex
Deposited on 2019-10-29, released 2020-10-28
The last revision was dated 2020-11-04, with a file datestamp of 2020-10-30.
Experiment type: XRAY
Resolution: 3.8 Å
R-factor: N/A
AEROSPACI score: 0.12 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Low-density lipoprotein receptor-related protein 6
    Species: Homo sapiens [TaxId:9606]
    Gene: LRP6
    Database cross-references and differences (RAF-indexed):
    • Uniprot O75581 (2-611)
      • expression tag (0-1)
  • Chain 'B':
    Compound: Low-density lipoprotein receptor-related protein 6
    Species: Homo sapiens [TaxId:9606]
    Gene: LRP6
    Database cross-references and differences (RAF-indexed):
    • Uniprot O75581 (2-611)
      • expression tag (1)
      • expression tag (612)
  • Chain 'C':
    Compound: Sclerostin
    Species: Homo sapiens [TaxId:9606]
    Gene: SOST, UNQ2976/PRO7455/PRO7476
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Sclerostin
    Species: Homo sapiens [TaxId:9606]
    Gene: SOST, UNQ2976/PRO7455/PRO7476
    Database cross-references and differences (RAF-indexed):
  • Heterogens: NAG, MG, ACT

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6l6rA (A:)
adplllyanrrdlrlvdatngkenativvggledaaavdfvfshgliywsdvseeaikrt
efnktesvqnvvvsgllspdglacdwlgeklywtdsetnrievsnldgslrkvlfwqeld
qpraialdpssgfmywtdwgevpkieragmdgssrfiiinseiywpngltldyeeqklyw
adaklnfihksnldgtnrqavvkgslphpfaltlfedilywtdwsthsilacnkytgegl
reihsdifspmdihafsqqrqpnatnpcgidnggcshlclmspvkpfyqcacptgvklle
ngktckdgatellllarrtdlrrisldtpdftdivlqledirhaiaidydpvegyiywtd
devrairrsfidgsgsqfvvtaqiahpdgiavdwvarnlywtdtgtdrievtrlngtmrk
ilisedleepraivldpmvgymywtdwgeipkieraaldgsdrvvlvntslgwpnglald
ydegkiywgdaktdkievmntdgtgrrvlvedkiphifgftllgdyvywtdwqrrsierv
hkrsaereviidqlpdlmglkatnvhrvigsnpcaeenggcshlclyrpqglrcacpigf
elisdmktcivphhhhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6l6rA (A:)
adplllyanrrdlrlvdatnenativvggledaaavdfvfshgliywsdvseeaikrtef
nktesvqnvvvsgllspdglacdwlgeklywtdsetnrievsnldgslrkvlfwqeldqp
raialdpssgfmywtdwgevpkieragmdgssrfiiinseiywpngltldyeeqklywad
aklnfihksnldgtnrqavvkgslphpfaltlfedilywtdwsthsilacnkytgeglre
ihsdifspmdihafsqqrqpnatnpcgidnggcshlclmspvkpfyqcacptgvklleng
ktckdgatellllarrtdlrrisldtpdftdivlqledirhaiaidydpvegyiywtdde
vrairrsfidgsgsqfvvtaqiahpdgiavdwvarnlywtdtgtdrievtrlngtmrkil
isedleepraivldpmvgymywtdwgeipkieraaldgsdrvvlvntslgwpnglaldyd
egkiywgdaktdkievmntdgtgrrvlvedkiphifgftllgdyvywtdwqrrsiervhk
rsaereviidqlpdlmglkatnvhrvigsnpcaeenggcshlclyrpqglrcacpigfel
isdmktcivp

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6l6rB (B:)
adplllyanrrdlrlvdatngkenativvggledaaavdfvfshgliywsdvseeaikrt
efnktesvqnvvvsgllspdglacdwlgeklywtdsetnrievsnldgslrkvlfwqeld
qpraialdpssgfmywtdwgevpkieragmdgssrfiiinseiywpngltldyeeqklyw
adaklnfihksnldgtnrqavvkgslphpfaltlfedilywtdwsthsilacnkytgegl
reihsdifspmdihafsqqrqpnatnpcgidnggcshlclmspvkpfyqcacptgvklle
ngktckdgatellllarrtdlrrisldtpdftdivlqledirhaiaidydpvegyiywtd
devrairrsfidgsgsqfvvtaqiahpdgiavdwvarnlywtdtgtdrievtrlngtmrk
ilisedleepraivldpmvgymywtdwgeipkieraaldgsdrvvlvntslgwpnglald
ydegkiywgdaktdkievmntdgtgrrvlvedkiphifgftllgdyvywtdwqrrsierv
hkrsaereviidqlpdlmglkatnvhrvigsnpcaeenggcshlclyrpqglrcacpigf
elisdmktcivphhhhhhhhhh

    Sequence, based on observed residues (ATOM records):
    >6l6rB (B:)
dplllyanrrdlrlvdatnenativvggledaaavdfvfshgliywsdvseeaikrtefn
ktesvqnvvvsgllspdglacdwlgeklywtdsetnrievsnldgslrkvlfwqeldqpr
aialdpssgfmywtdwgevpkieragmdgssrfiiinseiywpngltldyeeqklywada
klnfihksnldgtnrqavvkgslphpfaltlfedilywtdwsthsilacnkytgeglrei
hsdifspmdihafsqqrqpnatnpcgidnggcshlclmspvkpfyqcacptgvkllengk
tckdgatellllarrtdlrrisldtpdftdivlqledirhaiaidydpvegyiywtddev
rairrsfidgsgsqfvvtaqiahpdgiavdwvarnlywtdtgtdrievtrlngtmrkili
sedleepraivldpmvgymywtdwgeipkieraaldgsdrvvlvntslgwpnglaldyde
gkiywgdaktdkievmntdgtgrrvlvedkiphifgftllgdyvywtdwqrrsiervhkr
saereviidqlpdlmglkatnvhrvigsnpcaeenggcshlclyrpqglrcacpigfeli
sdmktcivph

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6l6rC (C:)
gpsrqgwqafkndateiipelgeypepppelennktmnraenggrpphhpfetkdvseys
crelhftryvtdgpcrsakpvtelvcsgqcgparllpnaigrgkwwrpsgpdfrcipdry
raqrvqllcpggeaprarkvrlvasckckrltrfhnqs

    Sequence, based on observed residues (ATOM records):
    >6l6rC (C:)
yscrelhftryvtdgpcrsakpvtelvcsgqcgparllpnaigrgpdfrcipdryraqrv
qllcpggeaprarkvrlvasckckrltrfhnqs

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6l6rD (D:)
gpsrqgwqafkndateiipelgeypepppelennktmnraenggrpphhpfetkdvseys
crelhftryvtdgpcrsakpvtelvcsgqcgparllpnaigrgkwwrpsgpdfrcipdry
raqrvqllcpggeaprarkvrlvasckckrltrfhnqs

    Sequence, based on observed residues (ATOM records):
    >6l6rD (D:)
yscrelhftryvtdgpcrsakpvtelvcsgqcgparllpnaigrdfrcipdryraqrvql
lcpggeaprarkvrlvasckckrltrfhnqs