PDB entry 6l50

View 6l50 on RCSB PDB site
Description: Crystal structure of Zika NS2B-NS3 protease with compound 16
Class: viral protein
Keywords: Viral protease, Protease inhibitor complex, VIRAL PROTEIN
Deposited on 2019-10-21, released 2020-07-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-15, with a file datestamp of 2020-07-10.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine protease subunit NS2B
    Species: Zika virus [TaxId:64320]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6l50a_
  • Chain 'B':
    Compound: NS3 protease
    Species: Zika virus (strain Mr 766) [TaxId:64320]
    Gene: GP1, A2G93_63394gpGP1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6l50b_
  • Chain 'C':
    Compound: Serine protease subunit NS2B
    Species: Zika virus [TaxId:64320]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6l50c_
  • Chain 'D':
    Compound: NS3 protease
    Species: Zika virus (strain Mr 766) [TaxId:64320]
    Gene: GP1, A2G93_63394gpGP1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6l50d_
  • Chain 'E':
    Compound: Serine protease subunit NS2B
    Species: Zika virus [TaxId:64320]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6l50e_
  • Chain 'F':
    Compound: NS3 protease
    Species: Zika virus (strain Mr 766) [TaxId:64320]
    Gene: GP1, A2G93_63394gpGP1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6l50f_
  • Chain 'G':
    Compound: Serine protease subunit NS2B
    Species: Zika virus [TaxId:64320]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6l50g_
  • Chain 'H':
    Compound: NS3 protease
    Species: Zika virus (strain Mr 766) [TaxId:64320]
    Gene: GP1, A2G93_63394gpGP1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6l50h_
  • Heterogens: E60, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6l50A (A:)
mtgksvdmyieragditwekdaevtgnsprldvaldesgdfslveedgppmre

    Sequence, based on observed residues (ATOM records): (download) 
    >6l50A (A:)
dmyieragditwekdaevtgnsprldvaldesgdfslv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6l50B (B:)
gsgalwdvpapkevkkgettdgvyrvmtrrllgstqvgvgvmqegvfhtmwhvtkgaalr
sgegrldpywgdvkqdlvsycgpwkldaawdglsevqllavppgerakniqtlpgifktk
dgdigavaldypagtsgspildkcgrviglygngvvikngsyvsaitqgkreeetpve

    Sequence, based on observed residues (ATOM records): (download) 
    >6l50B (B:)
ettdgvyrvmtrrllgstqvgvgvmqegvfhtmwhvtkgaalrsgegrldpywgdvkqdl
vsycgpwkldaawdglsevqllavppgerakniqtlpgifktkdgdigavaldypagtsg
spildkcgrviglygngvvikngsyvsaitqgkre

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6l50C (C:)
mtgksvdmyieragditwekdaevtgnsprldvaldesgdfslveedgppmre

    Sequence, based on observed residues (ATOM records): (download) 
    >6l50C (C:)
myieragditwekdaevtgnsprldvaldesgdfslv

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6l50D (D:)
gsgalwdvpapkevkkgettdgvyrvmtrrllgstqvgvgvmqegvfhtmwhvtkgaalr
sgegrldpywgdvkqdlvsycgpwkldaawdglsevqllavppgerakniqtlpgifktk
dgdigavaldypagtsgspildkcgrviglygngvvikngsyvsaitqgkreeetpve

    Sequence, based on observed residues (ATOM records): (download) 
    >6l50D (D:)
ettdgvyrvmtrrllgstqvgvgvmqegvfhtmwhvtkgaalrsgegrldpywgdvkqdl
vsycgpwkldaawdglsevqllavppgerakniqtlpgifktkdgdigavaldypagtsg
spildkcgrviglygngvvikngsyvsaitqgkr

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6l50E (E:)
mtgksvdmyieragditwekdaevtgnsprldvaldesgdfslveedgppmre

    Sequence, based on observed residues (ATOM records): (download) 
    >6l50E (E:)
myieragditwekdaevtgnsprldvaldesgdfslv

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6l50F (F:)
gsgalwdvpapkevkkgettdgvyrvmtrrllgstqvgvgvmqegvfhtmwhvtkgaalr
sgegrldpywgdvkqdlvsycgpwkldaawdglsevqllavppgerakniqtlpgifktk
dgdigavaldypagtsgspildkcgrviglygngvvikngsyvsaitqgkreeetpve

    Sequence, based on observed residues (ATOM records): (download) 
    >6l50F (F:)
ttdgvyrvmtrrgstqvgvgvmqegvfhtmwhvtkgaalrsgegrldpywgdvkqdlvsy
cgpwkldaawdglsevqllavppgerakniqtlpgifktkdgdigavaldypagtsgspi
ldkcgrviglygngvvikngsyvsaitqgk

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >6l50G (G:)
mtgksvdmyieragditwekdaevtgnsprldvaldesgdfslveedgppmre

    Sequence, based on observed residues (ATOM records): (download) 
    >6l50G (G:)
dmyieragditwekdaevtgnsprldvaldesgdfslv

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6l50H (H:)
gsgalwdvpapkevkkgettdgvyrvmtrrllgstqvgvgvmqegvfhtmwhvtkgaalr
sgegrldpywgdvkqdlvsycgpwkldaawdglsevqllavppgerakniqtlpgifktk
dgdigavaldypagtsgspildkcgrviglygngvvikngsyvsaitqgkreeetpve

    Sequence, based on observed residues (ATOM records): (download) 
    >6l50H (H:)
tdgvyrvmtrrgstqvgvgvmqegvfhtmwhvtkgaalrsgegrldpywgdvkqdlvsyc
gpwkldaawdglsevqllavppgerakniqtlpgifktkdgdigavaldypagtsgspil
dkcgrviglygngvvikngsyvsaitqgkr