PDB entry 6kx3

View 6kx3 on RCSB PDB site
Description: Crystal structure of RhoA protein with covalent inhibitor DC-Rhoin
Class: cell invasion
Keywords: inhibitor, covalent, complex, CELL INVASION
Deposited on 2019-09-09, released 2020-08-19
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-08-19, with a file datestamp of 2020-08-14.
Experiment type: XRAY
Resolution: 1.98 Å
R-factor: N/A
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: transforming protein rhoa
    Species: Homo sapiens [TaxId:9606]
    Gene: RHOA, ARH12, ARHA, RHO12
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61586 (Start-180)
      • engineered mutation (15)
      • engineered mutation (19)
      • engineered mutation (82)
      • engineered mutation (158)
    Domains in SCOPe 2.08: d6kx3a_
  • Heterogens: 8ZO, GDP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6kx3A (A:)
maairkklvivgdgavgktsllivfskdqfpevyvptvfenyvadievdgkqvelalwdt
agqedydrlrplsypdtdvilmvfsidspdslenipekwtpevkhfcpnvpiilvgnkkd
lrndehtrrelakmkqepvkpeegrdmanrigafgymetsaktkdgvrevfematraalq
a

    Sequence, based on observed residues (ATOM records): (download) 
    >6kx3A (A:)
airkklvivgdgavgktsllivfskdqfpevyvptvfenyvadievdgkqvelalwdtag
qedypdtdvilmvfsidspdslenipekwtpevkhfcpnvpiilvgnkkdlrndehtrre
lakmkqepvkpeegrdmanrigafgymetsaktkdgvrevfematraalqa