PDB entry 6ktr

View 6ktr on RCSB PDB site
Description: Crystal structure of fibroblast growth factor 19 in complex with Fab
Class: immune system/protein binding
Keywords: complex, growth factor, antibody, CELL CYCLE, IMMUNE SYSTEM-PROTEIN BINDING complex
Deposited on 2019-08-28, released 2020-07-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-08, with a file datestamp of 2020-07-03.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: G1A8-Fab-HC
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6KTR (0-End)
    Domains in SCOPe 2.08: d6ktra_
  • Chain 'B':
    Compound: G1A8-Fab-LC
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6KTR (0-End)
    Domains in SCOPe 2.08: d6ktrb1, d6ktrb2
  • Chain 'C':
    Compound: Fibroblast growth factor 19
    Species: Homo sapiens [TaxId:9606]
    Gene: FGF19, UNQ334/PRO533
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6ktrc_
  • Chain 'D':
    Compound: Fibroblast growth factor 19
    Species: Homo sapiens [TaxId:9606]
    Gene: FGF19, UNQ334/PRO533
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6ktrd_
  • Chain 'F':
    Compound: G1A8-Fab-HC
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6KTR (0-End)
    Domains in SCOPe 2.08: d6ktrf_
  • Chain 'G':
    Compound: G1A8-Fab-LC
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6KTR
    Domains in SCOPe 2.08: d6ktrg1, d6ktrg2
  • Heterogens: NA, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6ktrA (A:)
evqlletggglvqpggslrlscaasgftfssyamswvrqapgkglewvsaisgsggstyy
adsvkgrftisrdnskntlylqmnslraedtavyycakdnwqellfdywgqgtlvtvssa
stkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssg
lyslssvvtvpssslgtqtyicnvnhkpsntkvdkkaepkscdkththhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6ktrA (A:)
evqlletggglvqpggslrlscaasgftfssyamswvrqapgkglewvsaisgsggstyy
adsvkgrftisrdnskntlylqmnslraedtavyycakdnwqellfdywgqgtlvtvssa
stkgpsvfplaptaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvv
tvpssslgtqtyicnvnhkpsntkvdkkaep

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6ktrB (B:)
qagltqpasvsgspgqsitisctgtssdvggynyvswyqqhpgkapklmiydvsnrpsgv
sdrfsgsksgntasltisglqtedeadyycsswtrssglvfgggtqltvlgqpkaapsvt
lfppsseelqankatlvclisdfypgavtvawkadgspvkagvetttpskqsnnkyaass
ylsltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records): (download) 
    >6ktrB (B:)
qagltqpasvsgspgqsitisctgtssdvggynyvswyqqhpgkapklmiydvsnrpsgv
sdrfsgsksgntasltisglqtedeadyycsswtrssglvfgggtqltvlgqpkaapsvt
lfppsseelqankatlvclisdfypgavtvawkadgspvkagvetttpskqsnnkyaass
ylsltpeqwkshrsyscqvthegstvektvapt

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6ktrC (C:)
rplafsdagphvhygwgdpirlrhlytsgphglsscflriradgvvdcargqsahsllei
kavalrtvaikgvhsvrylcmgadgkmqgllqyseedcafeeeirpdgynvyrsekhrlp
vslssakqrqlyknrgflplshflpmlpmvpeepedlrghlesdmfsspletdsmdpfgl
vtgleavrspsfeksggghhhhhhlndifeaqkiewhe

    Sequence, based on observed residues (ATOM records): (download) 
    >6ktrC (C:)
gwgdpirlrhlytsgphglsscflriradgvvdcargqsahslleikavalrtvaikgvh
svrylcmgadgkmqgllqyseedcafeeeirpdgynvyrsekhrlpvslssakqrqlykn
rgflplshflpmlpmv

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6ktrD (D:)
rplafsdagphvhygwgdpirlrhlytsgphglsscflriradgvvdcargqsahsllei
kavalrtvaikgvhsvrylcmgadgkmqgllqyseedcafeeeirpdgynvyrsekhrlp
vslssakqrqlyknrgflplshflpmlpmvpeepedlrghlesdmfsspletdsmdpfgl
vtgleavrspsfeksggghhhhhhlndifeaqkiewhe

    Sequence, based on observed residues (ATOM records): (download) 
    >6ktrD (D:)
gwgdpirlrhlytsgphglsscflriradgvvdcargqsahslleikavalrtvaikgvh
svrylcmgadgkmqgllqyseedcafeeeirpdgynvyrsekhrlpvslssakqrqlykn
rgflplshflpmlpmv

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6ktrF (F:)
evqlletggglvqpggslrlscaasgftfssyamswvrqapgkglewvsaisgsggstyy
adsvkgrftisrdnskntlylqmnslraedtavyycakdnwqellfdywgqgtlvtvssa
stkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssg
lyslssvvtvpssslgtqtyicnvnhkpsntkvdkkaepkscdkththhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6ktrF (F:)
evqlletggglvqpggslrlscaasgftfssyamswvrqapgkglewvsaisgsggstyy
adsvkgrftisrdnskntlylqmnslraedtavyycakdnwqellfdywgqgtlvtvssa
stkgpsvfplapaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslssvvt
vpssslgtqtyicnvnhkpsntkvdkkaep

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >6ktrG (G:)
qagltqpasvsgspgqsitisctgtssdvggynyvswyqqhpgkapklmiydvsnrpsgv
sdrfsgsksgntasltisglqtedeadyycsswtrssglvfgggtqltvlgqpkaapsvt
lfppsseelqankatlvclisdfypgavtvawkadgspvkagvetttpskqsnnkyaass
ylsltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records): (download) 
    >6ktrG (G:)
agltqpasvsgspgqsitisctgtssdvggynyvswyqqhpgkapklmiydvsnrpsgvs
drfsgsksgntasltisglqtedeadyycsswtrssglvfgggtqltvlgqpkaapsvtl
fppsseelqankatlvclisdfypgavtvawkadgspvkagvetttpskqsnnkyaassy
lsltpeqwkshrsyscqvthegstvektvapt