PDB entry 6krh

View 6krh on RCSB PDB site
Description: Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis
Class: ligase
Keywords: Ligase
Deposited on 2019-08-21, released 2020-08-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-06-09, with a file datestamp of 2021-06-04.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA ligase A
    Species: Mycobacterium tuberculosis H37Rv [TaxId:83332]
    Gene: ligA, lig, Rv3014c, MTV012.28c
    Database cross-references and differences (RAF-indexed):
    • Uniprot P9WNV1 (0-320)
      • engineered mutation (228)
    Domains in SCOPe 2.08: d6krha_
  • Heterogens: AMP, NMN, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6krhA (A:)
qtapevlrqwqalaeevrehqfryyvrdapiisdaefdellrrlealeeqhpelrtpdsp
tqlvggagfatdfepvdhlermlsldnaftadelaawagrihaevgdaahylcelkidgv
alslvyregrltrastrgdgrtgedvtlnartiadvperltpgddypvpevlevrgevff
rlddfqalnaslveegkapfanprnsaagslrqkdpavtarrrlrmicyglghvegfrpa
tlhqaylalrawglpvsehttlatdlagvreridywgehrhevdheidgvvvkvdevalq
rrlgstsraprwaiaykyppehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6krhA (A:)
qtapevlrqwqalaeevrehqfryyvrdapiisdaefdellrrlealeeqhpelrtpdsp
tqlvggagfatdfepvdhlermlsldnaftadelaawagrihaevgdaahylcelkidgv
alslvyregrltrastrgdgrtgedvtlnartiadvperltpgddypvpevlevrgevff
rlddfqalnaslveegkapfanprnsaagslrqkdpavtarrrlrmicyglghvegfrpa
tlhqaylalrawglpvsehttlatdlagvreridywgehrhevdheidgvvvkvdevalq
rrlgstsraprwaiaykyppe