PDB entry 6kpy

View 6kpy on RCSB PDB site
Description: crystal structures of na+,k+-atpase in complex with istaroxime
Deposited on 2019-08-16, released 2020-09-02
Made obsolete by 7ddg on 2021-01-27

The last revision was dated 2021-01-27, with a file datestamp of 2021-01-22.
Experiment type: XRAY
Resolution: 3.71 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Sodium/potassium-transporting ATPase subunit alpha
    Species: Sus scrofa [TaxId:9823]
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Sodium/potassium-transporting ATPase subunit beta-1
    Species: Sus scrofa [TaxId:9823]
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Sodium/potassium-transporting ATPase subunit alpha
    Species: Sus scrofa [TaxId:9823]
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Sodium/potassium-transporting ATPase subunit beta-1
    Species: Sus scrofa [TaxId:9823]
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: FXYD domain-containing ion transport regulator
    Species: Sus scrofa [TaxId:9823]
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: FXYD domain-containing ion transport regulator
    Species: Sus scrofa [TaxId:9823]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: 1AT, CLR, F9U, MG, NA, NAG, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6kpyA (A:)
mafkvgrdkyepaavsehgdkkkakkerdmdelkkevsmddhklsldelhrkygtdlsrg
ltparaaeilardgpnaltpppttpewvkfcrqlfggfsmllwigailcflaygiqaate
eepqndnlylgvvlsavviitgcfsyyqeaksskimesfknmvpqqalvirngekmsina
eevvvgdlvevkggdripadlriisangckvdnssltgesepqtrspdftnenpletrni
affstncvegtargivvytgdrtvmgriatlasgleggqtpiaaeiehfihiitgvavfl
gvsffilslileytwleavifligiivanvpegllatvtvcltltakrmarknclvknle
avetlgststicsdktgtltqnrmtvahmwfdnqiheadttenqsgvsfdktsatwlals
riaglcnravfqanqenlpilkravagdasesallkcielccgsvkemrerytkiveipf
nstnkyqlsihknpntaeprhllvmkgaperildrcssilihgkeqpldeelkdafqnay
lelgglgervlgfchlflpdeqfpegfqfdtddvnfpldnlcfvglismidppraavpda
vgkcrsagikvimvtgdhpitakaiakgvgiisegnetvediaarlnipvsqvnprdaka
cvvhgsdlkdmtseqlddilkyhteivfartspqqkliivegcqrqgaivavtgdgvnds
palkkadigvamgiagsdvskqaadmillddnfasivtgveegrlifdnlkksiaytlts
nipeitpflifiianiplplgtvtilcidlgtdmvpaislayeqaesdimkrqprnpktd
klvnerlismaygqigmiqalggfftyfvilaengflpihllglrvnwddrwindvedsy
gqqwtyeqrkiveftchtaffvsivvvqwadlvicktrrnsvfqqgmknkilifglfeet
alaaflsycpgmgvalrmyplkptwwfcafpysllifvydevrkliirrrpggwvekety
y

    Sequence, based on observed residues (ATOM records):
    >6kpyA (A:)
kerdmdelkkevsmddhklsldelhrkygtdlsrgltparaaeilardgpnaltpppttp
ewvkfcrqlfggfsmllwigailcflaygiqaateeepqndnlylgvvlsavviitgcfs
yyqeaksskimesfknmvpqqalvirngekmsinaeevvvgdlvevkggdripadlriis
angckvdnssltgesepqtrspdftnenpletrniaffstncvegtargivvytgdrtvm
griatlasgleggqtpiaaeiehfihiitgvavflgvsffilslileytwleavifligi
ivanvpegllatvtvcltltakrmarknclvknleavetlgststicsdktgtltqnrmt
vahmwfdnqiheadttenqsgvsfdktsatwlalsriaglcnravfqanqenlpilkrav
agdasesallkcielccgsvkemrerytkiveipfnstnkyqlsihknpntaeprhllvm
kgaperildrcssilihgkeqpldeelkdafqnaylelgglgervlgfchlflpdeqfpe
gfqfdtddvnfpldnlcfvglismidppraavpdavgkcrsagikvimvtgdhpitakai
akgvgiisegnetvediaarlnipvsqvnprdakacvvhgsdlkdmtseqlddilkyhte
ivfartspqqkliivegcqrqgaivavtgdgvndspalkkadigvamgiagsdvskqaad
millddnfasivtgveegrlifdnlkksiaytltsnipeitpflifiianiplplgtvti
lcidlgtdmvpaislayeqaesdimkrqprnpktdklvnerlismaygqigmiqalggff
tyfvilaengflpihllglrvnwddrwindvedsygqqwtyeqrkiveftchtaffvsiv
vvqwadlvicktrrnsvfqqgmknkilifglfeetalaaflsycpgmgvalrmyplkptw
wfcafpysllifvydevrkliirrrpggwveketyy

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6kpyB (B:)
margkakeegswkkfiwnsekkeflgrtggswfkillfyvifygclagifigtiqvmllt
isefkptyqdrvappgltqipqsqkteisfrpndpqsyesyvvsivrflekykdlaqkdd
mifedcgnvpselkergeynnergerkvcrfrlewlgncsglndetygykdgkpcviikl
nrvlgfkpkppknesletypvmkynpyvlpvhctgkrdedkekvgtmeyfglggypgfpl
qyypyygkllqpkylqplmavqftnltmdteirieckaygenigysekdrfqgrfdvkie
vks

    Sequence, based on observed residues (ATOM records):
    >6kpyB (B:)
fiwnsekkeflgrtggswfkillfyvifygclagifigtiqvmlltisefkptyqdrvap
pgltqipqsqkteisfrpndpqsyesyvvsivrflekykdlaqkddmifedcgnvpselk
ergeynnergerkvcrfrlewlgncsglndetygykdgkpcviiklnrvlgfkpkppkne
sletypvmkynpyvlpvhctgkrdedkekvgtmeyfglggypgfplqyypyygkllqpky
lqplmavqftnltmdteirieckaygenigysekdrfqgrfdvkievks

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6kpyC (C:)
mafkvgrdkyepaavsehgdkkkakkerdmdelkkevsmddhklsldelhrkygtdlsrg
ltparaaeilardgpnaltpppttpewvkfcrqlfggfsmllwigailcflaygiqaate
eepqndnlylgvvlsavviitgcfsyyqeaksskimesfknmvpqqalvirngekmsina
eevvvgdlvevkggdripadlriisangckvdnssltgesepqtrspdftnenpletrni
affstncvegtargivvytgdrtvmgriatlasgleggqtpiaaeiehfihiitgvavfl
gvsffilslileytwleavifligiivanvpegllatvtvcltltakrmarknclvknle
avetlgststicsdktgtltqnrmtvahmwfdnqiheadttenqsgvsfdktsatwlals
riaglcnravfqanqenlpilkravagdasesallkcielccgsvkemrerytkiveipf
nstnkyqlsihknpntaeprhllvmkgaperildrcssilihgkeqpldeelkdafqnay
lelgglgervlgfchlflpdeqfpegfqfdtddvnfpldnlcfvglismidppraavpda
vgkcrsagikvimvtgdhpitakaiakgvgiisegnetvediaarlnipvsqvnprdaka
cvvhgsdlkdmtseqlddilkyhteivfartspqqkliivegcqrqgaivavtgdgvnds
palkkadigvamgiagsdvskqaadmillddnfasivtgveegrlifdnlkksiaytlts
nipeitpflifiianiplplgtvtilcidlgtdmvpaislayeqaesdimkrqprnpktd
klvnerlismaygqigmiqalggfftyfvilaengflpihllglrvnwddrwindvedsy
gqqwtyeqrkiveftchtaffvsivvvqwadlvicktrrnsvfqqgmknkilifglfeet
alaaflsycpgmgvalrmyplkptwwfcafpysllifvydevrkliirrrpggwvekety
y

    Sequence, based on observed residues (ATOM records):
    >6kpyC (C:)
kerdmdelkkevsmddhklsldelhrkygtdlsrgltparaaeilardgpnaltpppttp
ewvkfcrqlfggfsmllwigailcflaygiqaateeepqndnlylgvvlsavviitgcfs
yyqeaksskimesfknmvpqqalvirngekmsinaeevvvgdlvevkggdripadlriis
angckvdnssltgesepqtrspdftnenpletrniaffstncvegtargivvytgdrtvm
griatlasgleggqtpiaaeiehfihiitgvavflgvsffilslileytwleavifligi
ivanvpegllatvtvcltltakrmarknclvknleavetlgststicsdktgtltqnrmt
vahmwfdnqiheadttenqsgvsfdktsatwlalsriaglcnravfqanqenlpilkrav
agdasesallkcielccgsvkemrerytkiveipfnstnkyqlsihknpntaeprhllvm
kgaperildrcssilihgkeqpldeelkdafqnaylelgglgervlgfchlflpdeqfpe
gfqfdtddvnfpldnlcfvglismidppraavpdavgkcrsagikvimvtgdhpitakai
akgvgiisegnetvediaarlnipvsqvnprdakacvvhgsdlkdmtseqlddilkyhte
ivfartspqqkliivegcqrqgaivavtgdgvndspalkkadigvamgiagsdvskqaad
millddnfasivtgveegrlifdnlkksiaytltsnipeitpflifiianiplplgtvti
lcidlgtdmvpaislayeqaesdimkrqprnpktdklvnerlismaygqigmiqalggff
tyfvilaengflpihllglrvnwddrwindvedsygqqwtyeqrkiveftchtaffvsiv
vvqwadlvicktrrnsvfqqgmknkilifglfeetalaaflsycpgmgvalrmyplkptw
wfcafpysllifvydevrkliirrrpggwveketyy

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6kpyD (D:)
margkakeegswkkfiwnsekkeflgrtggswfkillfyvifygclagifigtiqvmllt
isefkptyqdrvappgltqipqsqkteisfrpndpqsyesyvvsivrflekykdlaqkdd
mifedcgnvpselkergeynnergerkvcrfrlewlgncsglndetygykdgkpcviikl
nrvlgfkpkppknesletypvmkynpyvlpvhctgkrdedkekvgtmeyfglggypgfpl
qyypyygkllqpkylqplmavqftnltmdteirieckaygenigysekdrfqgrfdvkie
vks

    Sequence, based on observed residues (ATOM records):
    >6kpyD (D:)
fiwnsekkeflgrtggswfkillfyvifygclagifigtiqvmlltisefkptyqdrvap
pgltqipqsqkteisfrpndpqsyesyvvsivrflekykdlaqkddmifedcgnvpselk
ergeynnergerkvcrfrlewlgncsggykdgkpcviiklnrvlgfkpkppknesletyp
vmkynpyvlpvhctgkrdedkekvgtmeyfglggypgfplqyypyygkllqpkylqplma
vqftnltmdteirieckaygenigysekdrfqgrfdvkievks

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6kpyE (E:)
maglstddggspkgdvdpfyydyetvrngglifaalafivgliiilskrlrcggkkhrpi
nedel

    Sequence, based on observed residues (ATOM records):
    >6kpyE (E:)
dpfyydyetvrngglifaalafivgliiilsk

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6kpyG (G:)
maglstddggspkgdvdpfyydyetvrngglifaalafivgliiilskrlrcggkkhrpi
nedel

    Sequence, based on observed residues (ATOM records):
    >6kpyG (G:)
dpfyydyetvrngglifaalafivgliiilsk