PDB entry 6kp7

View 6kp7 on RCSB PDB site
Description: quadruple mutant (n51i+c59r+s108n+i164l) plasmodium falciparum dihydrofolate reductase-thymidylate synthase (pfdhfr-ts) complexed with b12154
Deposited on 2019-08-14, released 2019-12-04
The last revision was dated 2019-12-04, with a file datestamp of 2019-11-29.
Experiment type: XRAY
Resolution: 1.97 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bifunctional dihydrofolate reductase-thymidylate synthase
    Species: Plasmodium falciparum [TaxId:5833]
    Gene: DHFR-TS, V1/S
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Bifunctional dihydrofolate reductase-thymidylate synthase
    Species: Plasmodium falciparum [TaxId:5833]
    Gene: DHFR-TS, V1/S
    Database cross-references and differences (RAF-indexed):
  • Heterogens: DQ9, NDP, UMP, GOL, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6kp7A (A:)
mmeqvcdvfdiyaicacckvesknegkknevfnnytfrglgnkgvlpwkcisldmkyfra
vttyvneskyeklkykrckylnketvdnvndmpnskklqnvvvmgrtnwesipkkfkpls
nrinvilsrtlkkedfdedvyiinkvedlivllgklnyykcfilggsvvyqeflekklik
kiyftrinstyecdvffpeineneyqiisvsdvytsnnttldfiiykktnnkmlneqnci
kgeeknndmplknddkdtchmkkltefyknvdkykinyenddddeeeddfvyfnfnkeke
eknknsihpndfqiynslkykyhpeyqylniiydimmngnkqsdrtgvgvlskfgyimkf
dlsqyfpllttkklflrgiieellwfirgetngntllnknvriweangtrefldnrklfh
revndlgpiygfqwrhfgaeytnmydnyenkgvdqlkniinlikndptsrrillcawnvk
dldqmalppchilcqfyvfdgklscimyqrscdlglgvpfniasysifthmiaqvcnlqp
aqfihvlgnahvynnhidslkiqlnripypfptlklnpdikniedftisdftiqnyvhhe
kismdmaa

    Sequence, based on observed residues (ATOM records):
    >6kp7A (A:)
qvcdvfdiyaicacckvesevfnnytfrglgnkgvlpwkcisldmkyfravttyvnesky
eklkykrckylnkklqnvvvmgrtnwesipkkfkplsnrinvilsrtlkkedfdedvyii
nkvedlivllgklnyykcfilggsvvyqeflekklikkiyftrinstyecdvffpeinen
eyqiisvsdvytsnnttldfiiykkteeddfvyfnfnkknsihpndfqiynslkykyhpe
yqylniiydimmngnkqsdrtgvgvlskfgyimkfdlsqyfpllttkklflrgiieellw
firgetngntllnknvriweangtrefldnrklfhrevndlgpiygfqwrhfgaeytnmy
dnyenkgvdqlkniinlikndptsrrillcawnvkdldqmalppchilcqfyvfdgklsc
imyqrscdlglgvpfniasysifthmiaqvcnlqpaqfihvlgnahvynnhidslkiqln
ripypfptlklnpdikniedftisdftiqnyvhhekismd

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6kp7B (B:)
mmeqvcdvfdiyaicacckvesknegkknevfnnytfrglgnkgvlpwkcisldmkyfra
vttyvneskyeklkykrckylnketvdnvndmpnskklqnvvvmgrtnwesipkkfkpls
nrinvilsrtlkkedfdedvyiinkvedlivllgklnyykcfilggsvvyqeflekklik
kiyftrinstyecdvffpeineneyqiisvsdvytsnnttldfiiykktnnkmlneqnci
kgeeknndmplknddkdtchmkkltefyknvdkykinyenddddeeeddfvyfnfnkeke
eknknsihpndfqiynslkykyhpeyqylniiydimmngnkqsdrtgvgvlskfgyimkf
dlsqyfpllttkklflrgiieellwfirgetngntllnknvriweangtrefldnrklfh
revndlgpiygfqwrhfgaeytnmydnyenkgvdqlkniinlikndptsrrillcawnvk
dldqmalppchilcqfyvfdgklscimyqrscdlglgvpfniasysifthmiaqvcnlqp
aqfihvlgnahvynnhidslkiqlnripypfptlklnpdikniedftisdftiqnyvhhe
kismdmaa

    Sequence, based on observed residues (ATOM records):
    >6kp7B (B:)
cdvfdiyaicacckvesknegkknevfnnytfrglgnkgvlpwkcisldmkyfravttyv
neskyeklkykrckylnknskklqnvvvmgrtnwesipkkfkplsnrinvilsrtlkked
fdedvyiinkvedlivllgklnyykcfilggsvvyqeflekklikkiyftrinstyecdv
ffpeineneyqiisvsdvytsnnttldfiiykktddeeeddfvyfnfnkenknsihpndf
qiynslkykyhpeyqylniiydimmngnkqsdrtgvgvlskfgyimkfdlsqyfpllttk
klflrgiieellwfirgetngntllnknvriweangtrefldnrklfhrevndlgpiygf
qwrhfgaeytnmydnyenkgvdqlkniinlikndptsrrillcawnvkdldqmalppchi
lcqfyvfdgklscimyqrscdlglgvpfniasysifthmiaqvcnlqpaqfihvlgnahv
ynnhidslkiqlnripypfptlklnpdikniedftisdftiqnyvhhekismd