PDB entry 6knu

View 6knu on RCSB PDB site
Description: THRb mutation with a novel agonist
Class: transcription
Keywords: agonist, thyroid hormone receptor, anemia, TRANSCRIPTION
Deposited on 2018-08-09, released 2019-10-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-03-04, with a file datestamp of 2020-02-28.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thyroid hormone receptor beta
    Species: Homo sapiens [TaxId:9606]
    Gene: THRB, ERBA2, NR1A2, THR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10828 (0-249)
      • engineered mutation (53)
    Domains in SCOPe 2.08: d6knua_
  • Chain 'C':
    Compound: nuclear receptor coactivator 2
    Species: Homo sapiens [TaxId:9606]
    Gene: NCOA2, BHLHE75, SRC2, TIF2
    Database cross-references and differences (RAF-indexed):
  • Heterogens: 8HO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6knuA (A:)
kpeptdeeweliktvteahvatnaqgshwkqkrkflpedigqapivnapeggkddleafs
hftkiitpaitrvvdfakklpmfcelpcedqiillkgccmeimslraavrydpesetltl
ngemavtrgqlkngglgvvsdaifdlgmslssfnlddtevallqavllmssdrpglacve
riekyqdsfllafehyinyrkhhvthfwpkllmkvtdlrmigachasrflhmkvecptel
fpplflevfe

    Sequence, based on observed residues (ATOM records): (download) 
    >6knuA (A:)
kpeptdeeweliktvteahvatnaqgshwkqkrkflpedigqapiddleafshftkiitp
aitrvvdfakklpmfcelpcedqiillkgccmeimslraavrydpesetltlngemavtr
gqlkngglgvvsdaifdlgmslssfnlddtevallqavllmssdrpglacveriekyqds
fllafehyinyrkhhvthfwpkllmkvtdlrmigachasrflhmkvecptelfpplflev
fe

  • Chain 'C':
    No sequence available.