PDB entry 6kke

View 6kke on RCSB PDB site
Description: THRb mutation with a novel agonist
Class: transcription
Keywords: agonist, thyroid hormone receptor, anemia, TRANSCRIPTION
Deposited on 2019-07-25, released 2019-10-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-03-04, with a file datestamp of 2020-02-28.
Experiment type: XRAY
Resolution: 2.58 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thyroid hormone receptor beta
    Species: Homo sapiens [TaxId:9606]
    Gene: THRB, ERBA2, NR1A2, THR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10828 (0-248)
      • engineered mutation (224)
    Domains in SCOPe 2.08: d6kkea_
  • Chain 'C':
    Compound: src2-3
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6KKE (0-10)
  • Heterogens: 8HO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6kkeA (A:)
kpeptdeeweliktvteahvatnaqgshwkqkrkflpedigqapivnapeggkvdleafs
hftkiitpaitrvvdfakklpmfcelpcedqiillkgccmeimslraavrydpesetltl
ngemavtrgqlkngglgvvsdaifdlgmslssfnlddtevallqavllmssdrpglacve
riekyqdsfllafehyinyrkhhvthfwpkllmkvtdlrmigaclasrflhmkvecptel
fpplflevf

    Sequence, based on observed residues (ATOM records): (download) 
    >6kkeA (A:)
kpeptdeeweliktvteahvatnaqgshwkqkrkflpedigqapikvdleafshftkiit
paitrvvdfakklpmfcelpcedqiillkgccmeimslraavrydpesetltlngemavt
rgqlkngglgvvsdaifdlgmslssfnlddtevallqavllmssdrpglacveriekyqd
sfllafehyinyrkhhvthfwpkllmkvtdlrmigaclasrflhmkvecptelfpplfle
vf

  • Chain 'C':
    No sequence available.