PDB entry 6kde

View 6kde on RCSB PDB site
Description: Crystal structure of the alpha beta heterodimer of human IDH3 in complex with Ca(2+)
Class: oxidoreductase
Keywords: NAD dependent isocitrate dehydrogenase, OXIDOREDUCTASE
Deposited on 2019-07-02, released 2019-09-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-25, with a file datestamp of 2019-12-20.
Experiment type: XRAY
Resolution: 3 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: IDH3A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6kdea_
  • Chain 'B':
    Compound: Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: IDH3B
    Database cross-references and differences (RAF-indexed):
    • Uniprot O43837 (Start-339)
      • expression tag (340-350)
    Domains in SCOPe 2.08: d6kdeb1, d6kdeb2
  • Chain 'C':
    Compound: Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: IDH3A
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6kdec_
  • Chain 'D':
    Compound: Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: IDH3B
    Database cross-references and differences (RAF-indexed):
    • Uniprot O43837 (Start-339)
      • expression tag (340-350)
    Domains in SCOPe 2.08: d6kded1, d6kded2
  • Heterogens: CA

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6kdeA (A:)
gstggvqtvtlipgdgigpeisaavmkifdaakapiqweernvtaiqgpggkwmipseak
esmdknkmglkgplktpiaaghpsmnlllrktfdlyanvrpcvsiegyktpytdvnivti
rentegeysgiehvivdgvvqsiklitegaskriaefafeyarnnhrsnvtavhkanimr
msdglflqkcrevaesckdikfnemyldtvclnmvqdpsqfdvlvmpnlygdilsdlcag
ligglgvtpsgnigangvaifesvhgtapdiagkdmanptalllsavmmlrhmglfdhaa
rieaacfatikdgksltkdlggnakcsdfteeicrrvkdld

    Sequence, based on observed residues (ATOM records): (download) 
    >6kdeA (A:)
gvqtvtlipgdgigpeisaavmkifdaakapiqweernvtaiqgpggkwmipseakesmd
knkmglkgplktpiaaghpsmnlllrktfdlyanvrpcvsiegyktpytdvnivtirent
egeysgiehvivdgvvqsiklitegaskriaefafeyarnnhrsnvtavhkanimrmsdg
lflqkcrevaesckdikfnemyldtvclnmvqdpsqfdvlvmpnlygdilsdlcagligg
lgvtpsgnigangvaifesvhgtapdiagkdmanptalllsavmmlrhmglfdhaariea
acfatikdgksltkdlggnakcsdfteeicrrvkdl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6kdeB (B:)
asrsqaedvrvegsfpvtmlpgdgvgpelmhavkevfkaaavpvefqehhlsevqnmase
ekleqvlssmkenkvaiigkihtpmeykgelasydmrlrrkldlfanvvhvkslpgymtr
hnnldlviireqtegeysslehesargvieclkivtraksqriakfafdyatkkgrgkvt
avhkanimklgdglflqcceevaelypkikfetmiidnccmqlvqnpyqfdvlvmpnlyg
niidnlaaglvggagvvpgesysaeyavfetgarhpfaqavgrnianptamllsasnmlr
hlnleyhssmiadavkkvikvgkvrtsdmggyatchdfteeicrrvkdldenlyfq

    Sequence, based on observed residues (ATOM records): (download) 
    >6kdeB (B:)
fpvtmlpgdgvgpelmhavkevfkaaavpvefqehhlekleqvlssmkenkvaiigksyd
mrlrrkldlfanvvhvkslpgymtrhnnldlviireqtegeysslehesargvieclkiv
traksqriakfafdyatkkgrgkvtavhkanimklgdglflqcceevaelypkikfetmi
idnccmqlvqnpyqfdvlvmpnlygniidnlaaglvggagvvpgesysaeyavfetgarh
pfaqavgrnianptamllsasnmlrhlnleyhssmiadavkkvikvgkvrtsdmggyatc
hdfteeicrrvkdlde

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6kdeC (C:)
gstggvqtvtlipgdgigpeisaavmkifdaakapiqweernvtaiqgpggkwmipseak
esmdknkmglkgplktpiaaghpsmnlllrktfdlyanvrpcvsiegyktpytdvnivti
rentegeysgiehvivdgvvqsiklitegaskriaefafeyarnnhrsnvtavhkanimr
msdglflqkcrevaesckdikfnemyldtvclnmvqdpsqfdvlvmpnlygdilsdlcag
ligglgvtpsgnigangvaifesvhgtapdiagkdmanptalllsavmmlrhmglfdhaa
rieaacfatikdgksltkdlggnakcsdfteeicrrvkdld

    Sequence, based on observed residues (ATOM records): (download) 
    >6kdeC (C:)
gvqtvtlipgdgigpeisaavmkifdaakapiqweernvtaiqgpggkwmipseakesmd
knkmglkgplktpiaaghpsmnlllrktfdlyanvrpcvsiegyktpytdvnivtirent
egeysgiehvivdgvvqsiklitegaskriaefafeyarnnhrsnvtavhkanimrmsdg
lflqkcrevaesckdikfnemyldtvclnmvqdpsqfdvlvmpnlygdilsdlcagligg
lgvtpsgnigangvaifesvhgtapdiagkdmanptalllsavmmlrhmglfdhaariea
acfatikdgksltkdlggnakcsdfteeicrrvkdl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6kdeD (D:)
asrsqaedvrvegsfpvtmlpgdgvgpelmhavkevfkaaavpvefqehhlsevqnmase
ekleqvlssmkenkvaiigkihtpmeykgelasydmrlrrkldlfanvvhvkslpgymtr
hnnldlviireqtegeysslehesargvieclkivtraksqriakfafdyatkkgrgkvt
avhkanimklgdglflqcceevaelypkikfetmiidnccmqlvqnpyqfdvlvmpnlyg
niidnlaaglvggagvvpgesysaeyavfetgarhpfaqavgrnianptamllsasnmlr
hlnleyhssmiadavkkvikvgkvrtsdmggyatchdfteeicrrvkdldenlyfq

    Sequence, based on observed residues (ATOM records): (download) 
    >6kdeD (D:)
fpvtmlpgdgvgpelmhavkevfkaaavpvefqehhlekleqvlssmkenkvaiigksyd
mrlrrkldlfanvvhvkslpgymtrhnnldlviireqtegeysslehesargvieclkiv
traksqriakfafdyatkkgrgkvtavhkanimklgdglflqcceevaelypkikfetmi
idnccmqlvqnpyqfdvlvmpnlygniidnlaaglvggagvvpgesysaeyavfetgarh
pfaqavgrnianptamllsasnmlrhlnleyhssmiadavkkvikvgkvrtsdmggyatc
hdfteeicrrvkdlde