PDB entry 6kcl

View 6kcl on RCSB PDB site
Description: crystal structure of plasmodium falciparum hppk-dhps a437g/k540e with pterin and p-hydroxybenzoate
Deposited on 2019-06-28, released 2020-02-12
The last revision was dated 2020-08-19, with a file datestamp of 2020-08-14.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase
    Species: Plasmodium falciparum [TaxId:5833]
    Gene: PPPK-DHPS
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q25704 (Start-705)
      • engineered mutation (539)
  • Chain 'B':
    Compound: 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase
    Species: Plasmodium falciparum [TaxId:5833]
    Gene: PPPK-DHPS
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q25704 (Start-705)
      • engineered mutation (539)
      • expression tag (706-721)
  • Heterogens: PE0, PHB, ATP, GOL, MG, CA, ACT, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6kclA (A:)
metiqelilseenktniavlnlgtndrrnavliletalhlvekylgkiintsylyetvpe
yivldkkescekinkdcriydvnyinelmqnleeskyeenkelidkceeyetflkngkvd
nsilkevnvenyllecnniivkndeimknnlskykdkyytsyfynltvvvktfvndplsm
lvvikyieelmkrenvkekekfenriididilffndftifmknikleknmiykilskyih
lerdikngndnmskvnmdkdinlnnnnnikkknnndidcdcvdqkmnnhvnnknyinsfr
dpqeiinnmvdnieflsiphvytthrysillclndmipeykhnvlnntirclynkyvsrm
keqyninikennkriyvlkdrisylkektnivgilnvnydsfsdggifvepkravqrmfe
minegasvidiggessgpfvipnpkiserdlvvpvlqlfqkewndiknkivkcdakpiis
idtinynvfkecvdndlvdilndisactnnpeiikllkkknkfysvvlmhkrgnphtmde
ltnydnlvydiknyleqrlnflvlngipryrilfdiglgfakkhdqsikllqnihvydey
plfigysrkrfiahcmndqnvvintqqklhdeqqnenknivdkshnwmfqmnymrkdkdq
llyqknicgglaiasysyykkvdlirvhdvletksvldvltkidqvkdpnsssvdklaaa
lehhhhhh

    Sequence, based on observed residues (ATOM records):
    >6kclA (A:)
qelilseenktniavlnlgtndrrnavliletalhlvekylgkiintsylyetvpvnyin
elmqnleeskyeenkelidkceeyetflkngkvdnsilkevnvenyllecnniivkndei
syfynltvvvktfvndplsmlvvikyieelmkriididilffndftifmknikleknmiy
kilskyihleeiinnmvdnieflsiphvytthrysillclndmipeykhnvlnntircly
nkyvsrmkeqyninikennkriyvlkdrisylkektnivgilnvnvepkravqrmfemin
egasvidiggeskiserdlvvpvlqlfqkewndiknkivkcdakpiisidtinynvfkec
vdndlvdilndisactnnpeiikllkkknkfysvvlmhkrgnphtmdeltnydnlvydik
nyleqrlnflvlngipryrilfdiglgfakkhdqsikllqnihvydeyplfigysrkrfi
ahcmndqllyqknicgglaiasysyykkvdlirvhdvletksvldvltkidqv

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6kclB (B:)
metiqelilseenktniavlnlgtndrrnavliletalhlvekylgkiintsylyetvpe
yivldkkescekinkdcriydvnyinelmqnleeskyeenkelidkceeyetflkngkvd
nsilkevnvenyllecnniivkndeimknnlskykdkyytsyfynltvvvktfvndplsm
lvvikyieelmkrenvkekekfenriididilffndftifmknikleknmiykilskyih
lerdikngndnmskvnmdkdinlnnnnnikkknnndidcdcvdqkmnnhvnnknyinsfr
dpqeiinnmvdnieflsiphvytthrysillclndmipeykhnvlnntirclynkyvsrm
keqyninikennkriyvlkdrisylkektnivgilnvnydsfsdggifvepkravqrmfe
minegasvidiggessgpfvipnpkiserdlvvpvlqlfqkewndiknkivkcdakpiis
idtinynvfkecvdndlvdilndisactnnpeiikllkkknkfysvvlmhkrgnphtmde
ltnydnlvydiknyleqrlnflvlngipryrilfdiglgfakkhdqsikllqnihvydey
plfigysrkrfiahcmndqnvvintqqklhdeqqnenknivdkshnwmfqmnymrkdkdq
llyqknicgglaiasysyykkvdlirvhdvletksvldvltkidqvkdpnsssvdklaaa
lehhhhhh

    Sequence, based on observed residues (ATOM records):
    >6kclB (B:)
qelilseenktniavlnlgtndrrnavliletalhlvekylgkiintsylyetvpnyine
lmqnleeskyeenkelidkceeyetflkngkvdnsilkevnvenyllecnniivkndeim
knnlsyfynltvvvktfvndplsmlvvikyieelmkiididilffndftifmkniklekn
miykilskyihlqeiinnmvdnieflsiphvytthrysillclndmipeykhnvlnntir
clynkyvsrmkeqyninikennkriyvlkdrisylkektnivgilnvnfvepkravqrmf
eminegasvidiggekiserdlvvpvlqlfqkewndakpiisidtinynvfkecvdndlv
dilndisactnnpeiikllkkknkfysvvlmhkrgnphtmdeltnydnlvydiknyleqr
lnflvlngipryrilfdiglgfakkhdqsikllqnihvydeyplfigysrkrfiahcmnd
kdqllyqknicgglaiasysyykkvdlirvhdvletksvldvltkidqvkdpnsssvdkl
aaale