PDB entry 6k0y

View 6k0y on RCSB PDB site
Description: Study of the interactions of a novel monoclonal antibody, mAb059c, with the hPD-1 receptor
Class: immune system
Keywords: PD-1 Complex, Immune Checkpoint, Inhibitor, IMMUNE SYSTEM
Deposited on 2019-05-08, released 2019-12-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-11, with a file datestamp of 2019-12-06.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: N/A
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: antibody heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6K0Y (0-217)
    Domains in SCOPe 2.08: d6k0ya1, d6k0ya2
  • Chain 'B':
    Compound: Antibody Light Chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6K0Y (0-End)
    Domains in SCOPe 2.08: d6k0yb1, d6k0yb2
  • Chain 'C':
    Compound: Programmed cell death protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: Pdcd1, Pd1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q15116
      • engineered mutation (68)
    Domains in SCOPe 2.08: d6k0yc_
  • Heterogens: EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6k0yA (A:)
qvqlqesgpglvkpsetlsltcavsghsirgsyfwgwirqppgrglewigsiyhsgstyt
npslksratisvdtsknqfslklnsvtaadtavyycardldiattrdywgqgtlvtvssa
stkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssg
lyslssvvtvpssslgtktytcnvdhkpsntkvdkrve

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6k0yB (B:)
diqltqspsflsasvgdrvtiicrasqginnylawyqqkpgkapklliyaastlqsgvps
rfsgsgsgteftltisslqpedfatyycqqldsyprtfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >6k0yB (B:)
diqltqspsflsasvgdrvtiicrasqginnylawyqqkpgkapklliyaastlqsgvps
rfsgsgsgteftltisslqpedfatyycqqldsyprtfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrge

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6k0yC (C:)
ldspdrpwnpptfspallvvtegdnatftcsfsntsesfvlnwyrmspsnqtdklaafpe
drsqpgqdsrfrvtqlpngrdfhmsvvrarrndsgtylcgaislapkaqikeslraelrv
terraevptahpspsprpagqfq

    Sequence, based on observed residues (ATOM records): (download) 
    >6k0yC (C:)
npptfspallvvtegdnatftcsfsntsesfvlnwyrmspsnqtdklaafpedrsqpgqd
srfrvtqlpngrdfhmsvvrarrndsgtylcgaislapkaqikeslraelrvterr