PDB entry 6k05

View 6k05 on RCSB PDB site
Description: Crystal structure of BRD2(BD1)with ligand BY27 bound
Class: antitumor protein
Keywords: Antitumor; BET proteins; Bromodomain inhibitor; Epigenetic readers, ANTITUMOR PROTEIN
Deposited on 2019-05-05, released 2019-09-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-09-25, with a file datestamp of 2019-09-20.
Experiment type: XRAY
Resolution: 1.94 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bromodomain-containing protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD2, KIAA9001, RING3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6k05a_
  • Chain 'B':
    Compound: Bromodomain-containing protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD2, KIAA9001, RING3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6k05b_
  • Chain 'C':
    Compound: Bromodomain-containing protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: BRD2, KIAA9001, RING3
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6k05c_
  • Heterogens: CQF, MES, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6k05A (A:)
grvtnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlen
nyywaasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpqeeqelvvtip
kn

    Sequence, based on observed residues (ATOM records): (download) 
    >6k05A (A:)
tnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlennyy
waasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpqe

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6k05B (B:)
grvtnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlen
nyywaasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpqeeqelvvtip
kn

    Sequence, based on observed residues (ATOM records): (download) 
    >6k05B (B:)
tnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlennyy
waasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpq

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6k05C (C:)
grvtnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlen
nyywaasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmpqeeqelvvtip
kn

    Sequence, based on observed residues (ATOM records): (download) 
    >6k05C (C:)
tnqlqylhkvvmkalwkhqfawpfrqpvdavklglpdyhkiikqpmdmgtikrrlennyy
waasecmqdfntmftncyiynkptddivlmaqtlekiflqkvasmp