PDB entry 6jwz

View 6jwz on RCSB PDB site
Description: crystal structure of plasmodium falciparum hppk-dhps s436f/a437g/a613s triple mutant with sdx-dhp
Deposited on 2019-04-21, released 2020-02-12
The last revision was dated 2020-08-19, with a file datestamp of 2020-08-14.
Experiment type: XRAY
Resolution: 2.95 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase
    Species: Plasmodium falciparum [TaxId:5833]
    Gene: PPPK-DHPS
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q25704 (Start-705)
      • engineered mutation (612)
      • expression tag (706-707)
  • Chain 'B':
    Compound: 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase
    Species: Plasmodium falciparum [TaxId:5833]
    Gene: PPPK-DHPS
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q25704 (Start-705)
      • engineered mutation (435)
      • engineered mutation (612)
      • expression tag (706-721)
  • Heterogens: CKL, PO4, AMP, MG, CA, ACT, PEG, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6jwzA (A:)
metiqelilseenktniavlnlgtndrrnavliletalhlvekylgkiintsylyetvpe
yivldkkescekinkdcriydvnyinelmqnleeskyeenkelidkceeyetflkngkvd
nsilkevnvenyllecnniivkndeimknnlskykdkyytsyfynltvvvktfvndplsm
lvvikyieelmkrenvkekekfenriididilffndftifmknikleknmiykilskyih
lerdikngndnmskvnmdkdinlnnnnnikkknnndidcdcvdqkmnnhvnnknyinsfr
dpqeiinnmvdnieflsiphvytthrysillclndmipeykhnvlnntirclynkyvsrm
keqyninikennkriyvlkdrisylkektnivgilnvnydsfsdggifvepkravqrmfe
minegasvidiggesfgpfvipnpkiserdlvvpvlqlfqkewndiknkivkcdakpiis
idtinynvfkecvdndlvdilndisactnnpeiikllkkknkfysvvlmhkrgnphtmdk
ltnydnlvydiknyleqrlnflvlngipryrilfdiglgfakkhdqsikllqnihvydey
plfigysrkrfishcmndqnvvintqqklhdeqqnenknivdkshnwmfqmnymrkdkdq
llyqknicgglaiasysyykkvdlirvhdvletksvldvltkidqvkdpnsssvdklaaa
lehhhhhh

    Sequence, based on observed residues (ATOM records):
    >6jwzA (A:)
qelilseenktniavlnlgtndrrnavliletalhlvekylgkiintsylyetvpevnyi
nelmqnleeskyeenkelidkceeyetflkngkvdnsilkevnvenyllecnniivknde
imknnlsyfynltvvvktfvndplsmlvvikyieelmkreriididilffndftifmkni
kleknmiykilskyihlepqeiinnmvdnieflsiphvytthrysillclndmipeykhn
vlnntirclynkyvsrmkeqyninikennkriyvlkdrisylkektnivgilnvnvepkr
avqrmfeminegasvidiggespnpkiserdlvvpvlqlfqkewndiknkivkcdakpii
sidtinynvfkecvdndlvdilndisactnnpeiikllkkknkfysvvlmhkrgnphtmd
kltnydnlvydiknyleqrlnflvlngipryrilfdiglgfakkhdqsikllqnihvyde
yplfigysrkrfishcmndkdqllyqknicgglaiasysyykkvdlirvhdvletksvld
vltkidqvkd

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6jwzB (B:)
metiqelilseenktniavlnlgtndrrnavliletalhlvekylgkiintsylyetvpe
yivldkkescekinkdcriydvnyinelmqnleeskyeenkelidkceeyetflkngkvd
nsilkevnvenyllecnniivkndeimknnlskykdkyytsyfynltvvvktfvndplsm
lvvikyieelmkrenvkekekfenriididilffndftifmknikleknmiykilskyih
lerdikngndnmskvnmdkdinlnnnnnikkknnndidcdcvdqkmnnhvnnknyinsfr
dpqeiinnmvdnieflsiphvytthrysillclndmipeykhnvlnntirclynkyvsrm
keqyninikennkriyvlkdrisylkektnivgilnvnydsfsdggifvepkravqrmfe
minegasvidiggesfgpfvipnpkiserdlvvpvlqlfqkewndiknkivkcdakpiis
idtinynvfkecvdndlvdilndisactnnpeiikllkkknkfysvvlmhkrgnphtmdk
ltnydnlvydiknyleqrlnflvlngipryrilfdiglgfakkhdqsikllqnihvydey
plfigysrkrfishcmndqnvvintqqklhdeqqnenknivdkshnwmfqmnymrkdkdq
llyqknicgglaiasysyykkvdlirvhdvletksvldvltkidqvkdpnsssvdklaaa
lehhhhhh

    Sequence, based on observed residues (ATOM records):
    >6jwzB (B:)
iqelilseenktniavlnlgtndrrnavliletalhlvekylgkiintsylyetvpyine
lmqnleeskyeenkelidkceeyetflkngkvdnsilkevnvenyllecnniivkndeim
knnsyfynltvvvktfvndplsmlvvikyieelmkriididilffndftifmkniklekn
miykilskyihlqeiinnmvdnieflsiphvytthrysillclndmipeykhnvlnntir
clynkyvsrmkeqyninikennkriyvlkdrisylkektnivgilnvnydsfsdggifve
pkravqrmfeminegasvidiggesfkiserdlvvpvlqlfqkewndiknkivkcdakpi
isidtinynvfkecvdndlvdilndisactnnpeiikllkkknkfysvvlmhkrgnphtm
dkltnydnlvydiknyleqrlnflvlngipryrilfdiglgfakkhdqsikllqnihvyd
eyplfigysrkrfishcmndkdqllyqknicgglaiasysyykkvdlirvhdvletksvl
dvltkidqvkdpnsssvdklaaale