PDB entry 6jwu

View 6jwu on RCSB PDB site
Description: crystal structure of plasmodium falciparum hppk-dhps wild type with stz-dhp
Deposited on 2019-04-21, released 2020-02-12
The last revision was dated 2020-08-19, with a file datestamp of 2020-08-14.
Experiment type: XRAY
Resolution: 2.65 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase
    Species: Plasmodium falciparum [TaxId:5833]
    Gene: PPPK-DHPS
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q25704 (Start-705)
      • expression tag (706-707)
  • Chain 'B':
    Compound: 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase-dihydropteroate synthase
    Species: Plasmodium falciparum [TaxId:5833]
    Gene: PPPK-DHPS
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q25704 (Start-705)
      • expression tag (706-721)
  • Heterogens: XTZ, PH2, PO4, AMP, MG, CA, ACT, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6jwuA (A:)
metiqelilseenktniavlnlgtndrrnavliletalhlvekylgkiintsylyetvpe
yivldkkescekinkdcriydvnyinelmqnleeskyeenkelidkceeyetflkngkvd
nsilkevnvenyllecnniivkndeimknnlskykdkyytsyfynltvvvktfvndplsm
lvvikyieelmkrenvkekekfenriididilffndftifmknikleknmiykilskyih
lerdikngndnmskvnmdkdinlnnnnnikkknnndidcdcvdqkmnnhvnnknyinsfr
dpqeiinnmvdnieflsiphvytthrysillclndmipeykhnvlnntirclynkyvsrm
keqyninikennkriyvlkdrisylkektnivgilnvnydsfsdggifvepkravqrmfe
minegasvidiggessapfvipnpkiserdlvvpvlqlfqkewndiknkivkcdakpiis
idtinynvfkecvdndlvdilndisactnnpeiikllkkknkfysvvlmhkrgnphtmdk
ltnydnlvydiknyleqrlnflvlngipryrilfdiglgfakkhdqsikllqnihvydey
plfigysrkrfiahcmndqnvvintqqklhdeqqnenknivdkshnwmfqmnymrkdkdq
llyqknicgglaiasysyykkvdlirvhdvletksvldvltkidqvkdpnsssvdklaaa
lehhhhhh

    Sequence, based on observed residues (ATOM records):
    >6jwuA (A:)
etiqelilseenktniavlnlgtndrrnavliletalhlvekylgkiintsylyetvpey
ivnyinelmqnleeskyeenkelidkceeyetflkngkvdnsilkevnvenyllecnnii
vkndeimknsyfynltvvvktfvndplsmlvvikyieelmkiididilffndftifmkni
kleknmiykilskyihledpqeiinnmvdnieflsiphvytthrysillclndmipeykh
nvlnntirclynkyvsrmkeqyninikennkriyvlkdrisylkektnivgilnvngifv
epkravqrmfeminegasvidiggessapfvipnpkiserdlvvpvlqlfqkewndiivk
cdakpiisidtinynvfkecvdndlvdilndisactnnpeiikllkkknkfysvvlmhkr
gnphtmdkltnydnlvydiknyleqrlnflvlngipryrilfdiglgfakkhdqsikllq
nihvydeyplfigysrkrfiahcmnddkdqllyqknicgglaiasysyykkvdlirvhdv
letksvldvltkidqvkd

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6jwuB (B:)
metiqelilseenktniavlnlgtndrrnavliletalhlvekylgkiintsylyetvpe
yivldkkescekinkdcriydvnyinelmqnleeskyeenkelidkceeyetflkngkvd
nsilkevnvenyllecnniivkndeimknnlskykdkyytsyfynltvvvktfvndplsm
lvvikyieelmkrenvkekekfenriididilffndftifmknikleknmiykilskyih
lerdikngndnmskvnmdkdinlnnnnnikkknnndidcdcvdqkmnnhvnnknyinsfr
dpqeiinnmvdnieflsiphvytthrysillclndmipeykhnvlnntirclynkyvsrm
keqyninikennkriyvlkdrisylkektnivgilnvnydsfsdggifvepkravqrmfe
minegasvidiggessapfvipnpkiserdlvvpvlqlfqkewndiknkivkcdakpiis
idtinynvfkecvdndlvdilndisactnnpeiikllkkknkfysvvlmhkrgnphtmdk
ltnydnlvydiknyleqrlnflvlngipryrilfdiglgfakkhdqsikllqnihvydey
plfigysrkrfiahcmndqnvvintqqklhdeqqnenknivdkshnwmfqmnymrkdkdq
llyqknicgglaiasysyykkvdlirvhdvletksvldvltkidqvkdpnsssvdklaaa
lehhhhhh

    Sequence, based on observed residues (ATOM records):
    >6jwuB (B:)
qelilseenktniavlnlgtndrrnavliletalhlvekylgkiintsylyetvpinelm
qnleeskyeenkelidkceeyetflkngkvdnsilkevnvenyllecnniivkndfynlt
vvvktfvndplsmlvvikyieelmiididilffndftifmknikleknmiykilskyihl
innmvdnieflsiphvytthrysillclndmipeykhnvlnntirclynkyvsrmkeqyn
inikennkriyvlkdrisylkektnivgilnvnyvepkravqrmfeminegasvidigge
kiserdlvvpvlqlfqkewndikcdakpiisidtinynvfkecvdndlvdilndisactn
npeiikllkkknkfysvvlmhkrgnphtmdkltnydnlvydiknyleqrlnflvlngipr
yrilfdiglgfakkhdqsikllqnihvydeyplfigysrkrfiahcmndkdqllyqknic
gglaiasysyykkvdlirvhdvletksvldvltkidqvkdpnsssvdklaaale