PDB entry 6jwl

View 6jwl on RCSB PDB site
Description: Crystal structure of EGFR 696-1022 L858R in complex with AZD9291
Class: transferase
Keywords: Complex, Inhibitor, EGFR., ONCOPROTEIN, TRANSFERASE
Deposited on 2019-04-21, released 2020-04-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-11-04, with a file datestamp of 2020-10-30.
Experiment type: XRAY
Resolution: 2.55 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533 (4-End)
      • engineered mutation (166)
    Domains in SCOPe 2.08: d6jwla_
  • Heterogens: YY3, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6jwlA (A:)
gamggeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreat
spkankeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigs
qyllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgrakllgaeekeyha
eggkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekge
rlpqppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlps
ptdsnfyralmdeedmddvvdadeylipqqg

    Sequence, based on observed residues (ATOM records): (download) 
    >6jwlA (A:)
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkdnigsqyll
nwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfgrakllgaeeggkvpikwm
alesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppicti
dvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlpsptdsnfyral
mdeedmddvvdadeylipq