PDB entry 6jvq
View 6jvq on RCSB PDB site
Description: Crystal structure of human MTH1 in complex with compound MI1025
Class: hydrolase
Keywords: MTH1, Oxidative DNA damage, 8-oxo-dGTP, Inhibitor development, HYDROLASE
Deposited on
2019-04-17, released
2020-10-28
The last revision prior to the SCOPe 2.08 freeze date was dated
2021-05-12, with a file datestamp of
2021-05-07.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.33
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: 7,8-dihydro-8-oxoguanine triphosphatase
Species: Homo sapiens [TaxId:9606]
Gene: NUDT1, MTH1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6jvqa_ - Chain 'B':
Compound: 7,8-dihydro-8-oxoguanine triphosphatase
Species: Homo sapiens [TaxId:9606]
Gene: NUDT1, MTH1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d6jvqb_ - Heterogens: CJF, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>6jvqA (A:)
mgasrlytlvlvlqpqrvllgmkkrgfgagrwngfggkvqegetiedgarrelqeesglt
vdalhkvgqivfefvgepelmdvhvfctdsiqgtpvesdemrpcwfqldqipfkdmwpdd
sywfplllqkkkfhgyfkfqgqdtildytlrevdtv
Sequence, based on observed residues (ATOM records): (download)
>6jvqA (A:)
asrlytlvlvlqpqrvllgmkkrgfgagrwngfggkvqegetiedgarrelqeesgltvd
alhkvgqivfefvgepelmdvhvfctdsiqgtpvesdemrpcwfqldqipfkdmwpddsy
wfplllqkkkfhgyfkfqgqdtildytlrevdtv
- Chain 'B':
Sequence, based on SEQRES records: (download)
>6jvqB (B:)
mgasrlytlvlvlqpqrvllgmkkrgfgagrwngfggkvqegetiedgarrelqeesglt
vdalhkvgqivfefvgepelmdvhvfctdsiqgtpvesdemrpcwfqldqipfkdmwpdd
sywfplllqkkkfhgyfkfqgqdtildytlrevdtv
Sequence, based on observed residues (ATOM records): (download)
>6jvqB (B:)
gasrlytlvlvlvllgmkkrgfgagrwngfggkvqegetiedgarrelqeesgltvdalh
kvgqivfefvgepelmdvhvfctdsiqgtpvesdemrpcwfqldqipfkdmwpddsywfp
lllqkkkfhgyfkfqgqdtildytlrevdtv