PDB entry 6jvi

View 6jvi on RCSB PDB site
Description: Crystal structure of human MTH1 in complex with compound MI0861
Class: hydrolase
Keywords: MTH1, Oxidative DNA damage, 8-oxo-dGTP, Inhibitor development, HYDROLASE
Deposited on 2019-04-17, released 2020-10-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2021-05-12, with a file datestamp of 2021-05-07.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 7,8-dihydro-8-oxoguanine triphosphatase
    Species: Homo sapiens [TaxId:9606]
    Gene: NUDT1, MTH1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6jvia_
  • Chain 'B':
    Compound: 7,8-dihydro-8-oxoguanine triphosphatase
    Species: Homo sapiens [TaxId:9606]
    Gene: NUDT1, MTH1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6jvib_
  • Heterogens: 95R, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6jviA (A:)
mgasrlytlvlvlqpqrvllgmkkrgfgagrwngfggkvqegetiedgarrelqeesglt
vdalhkvgqivfefvgepelmdvhvfctdsiqgtpvesdemrpcwfqldqipfkdmwpdd
sywfplllqkkkfhgyfkfqgqdtildytlrevdtv

    Sequence, based on observed residues (ATOM records): (download) 
    >6jviA (A:)
asrlytlvlvlqpqrvllgmkkrgfgagrwngfggkvqegetiedgarrelqeesgltvd
alhkvgqivfefvgepelmdvhvfctdsiqgtpvesdemrpcwfqldqipfkdmwpddsy
wfplllqkkkfhgyfkfqgqdtildytlrevdtv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6jviB (B:)
mgasrlytlvlvlqpqrvllgmkkrgfgagrwngfggkvqegetiedgarrelqeesglt
vdalhkvgqivfefvgepelmdvhvfctdsiqgtpvesdemrpcwfqldqipfkdmwpdd
sywfplllqkkkfhgyfkfqgqdtildytlrevdtv

    Sequence, based on observed residues (ATOM records): (download) 
    >6jviB (B:)
gasrlytlvlvlvllgmkkrgfgagrwngfggkvqegetiedgarrelqeesgltvdalh
kvgqivfefvgepelmdvhvfctdsiqgtpvesdemrpcwfqldqipfkdmwpddsywfp
lllqkkkfhgyfkfqgqdtildytlrevdtv