PDB entry 6jt2

View 6jt2 on RCSB PDB site
Description: structure of human soluble guanylate cyclase in the no activated state
Deposited on 2019-04-08, released 2019-09-04
The last revision was dated 2019-10-23, with a file datestamp of 2019-10-18.
Experiment type: EM
Resolution: 3.8 Å
R-factor: N/A
AEROSPACI score: 0.07 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Guanylate cyclase soluble subunit alpha-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GUCY1A1, GUC1A3, GUCSA3, GUCY1A3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q02108
      • variant (553)
  • Chain 'B':
    Compound: guanylate cyclase soluble subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GUCY1B1, GUC1B3, GUCSB3, GUCY1B3
    Database cross-references and differences (RAF-indexed):
  • Heterogens: G2P, MG, HEM

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6jt2A (A:)
mfctklkdlkitgecpfsllapgqvpnesseeaagssesckatmpicqdipekniqeslp
qrktsrsrvylhtlaesicklifpeferlnvalqrtlakhkikesrksleredfektiae
qavaagvpvevikeslgeevfkicyeedenilgvvggtlkdflnsfstllkqsshcqeag
krgrledasilcldkeddflhvyyffpkrttslilpgiikaaahvlyetevevslmppcf
hndcsefvnqpyllysvhmkstkpslspskpqsslviptslfcktfpfhfmfdkdmtilq
fgngirrlmnrrdfqgkpnfeeyfeiltpkinqtfsgimtmlnmqfvvrvrrwdnsvkks
srvmdlkgqmiyivessailflgspcvdrledftgrglylsdipihnalrdvvligeqar
aqdglkkrlgklkatleqahqaleeekkktvdllcsifpcevaqqlwqgqvvqakkfsnv
tmlfsdivgftaicsqcsplqvitmlnalytrfdqqcgeldvykvetigdaycvagglhk
esdthavqialmavkmmelsdevmsphgepikmriglhsgsvfagvvgvkmpryclfgnn
vtlankfescsvprkinvspttyrllkdcpgfvftprsreelppnfpseipgichflday
qqgtnskpcfqkkdvedgnanflgkasgid

    Sequence, based on observed residues (ATOM records):
    >6jt2A (A:)
srvylhtlaesicklifpeferlnvalqrtlakhkfektiaeqavaagvpvevikeslge
evfkicyeedenilgvvggtlkdflnsfstllkqasilcllhvyyffpkrttslilpgii
kaaahvlyetevevslyllysvhslviptslfcktfpfhfmfdkdmtilqfgngirrlmn
rrdkpnfeeyfeiltpkinqtfsgimtmlnmqfvvrvrrvmdlkgqmiyivessailflg
spcvlylsdipihnalrdvvligeqaraqdglkkrlgklkatleqahqaleeekkktvdl
lcsifpcevaqqlwqgqvvqakkfsnvtmlfsdivgftaicsqcsplqvitmlnalytrf
dqqcgeldvykvetigdaycvagglhkesdthavqialmavkmmelsdevmsphgepikm
riglhsgsvfagvvgvkmpryclfgnnvtlankfescsvprkinvspttyrllkdcpgfv
ftprsreelppnfpseipgichflda

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6jt2B (B:)
mygfvnhalellvirnygpevwedikkeaqldeegqflvriiyddsktydlvaaaskvln
lnageilqmfgkmffvfcqesgydtilrvlgsnvreflqnldalhdhlatiypgmrapsf
rctdaekgkglilhyysereglqdivigiiktvaqqihgteidmkviqqrneecdhtqfl
ieekeskeedfyedldrfeengtqesrispytfckafpfhiifdrdlvvtqcgnaiyrvl
pqlqpgncsllsvfslvrphidisfhgilshintvfvlrskeglldveklecedeltgte
isclrlkgqmiylpeadsilflcspsvmnlddltrrglylsdiplhdatrdlvllgeqfr
eeykltqeleiltdrlqltlraledekkktdtllysvlppsvanelrhkrpvpakrydnv
tilfsgivgfnafcskhasgegamkivnllndlytrfdtltdsrknpfvykvetvgdkym
tvsglpepcihharsichlaldmmeiagqvqvdgesvqitigihtgevvtgvigqrmpry
clfgntvnltsrtettgekgkinvseytyrclmspensdpqfhlehrgpvsmkgkkepmq
vwflsrkntgteetkqddd

    Sequence, based on observed residues (ATOM records):
    >6jt2B (B:)
mygfvnhalellvirnygpevwedikkeaqldeegqflvriiyddsktydlvaaaskvln
lnageilqmfgkmffvfcqesgydtilrvlgsnvreflqnldalhdhlatiypgmrapsf
rctdaekgkglilhyysereglqdivigiiktvaqqihgteidmkviqqrneecdhtqfl
ieekeesrispytfckafpfhiifdrdlvvtqcgnaiyrvlpqlqpgncsllsvfslvrp
hidisfhgilshintvfvlrskeglldsclrlkgqmiylpeadsilflcspsvmnlddlt
rrglylsdiplhdatrdlvllgeqfreeykltqeleiltdrlqltlraledekkktdtll
ysvlppsvanelrhkrpvpakrydnvtilfsgivgfnafcskhagamkivnllndlytrf
dtltdsrknpfvykvetvgdkymtvsglpepcihharsichlaldmmeiagqvqvdgesv
qitigihtgevvtgvigqrmpryclfgntvnltsrtettgekgkinvseytyrclmspen
sdpqfhlehrgpvsmkgkkepmqvwflsr