PDB entry 6jt1

View 6jt1 on RCSB PDB site
Description: structure of human soluble guanylate cyclase in the heme oxidised state
Deposited on 2019-04-08, released 2019-08-28
The last revision was dated 2019-11-20, with a file datestamp of 2019-11-15.
Experiment type: EM
Resolution: 3.9 Å
R-factor: N/A
AEROSPACI score: 0.06 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Guanylate cyclase soluble subunit alpha-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GUCY1A1, GUC1A3, GUCSA3, GUCY1A3
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q02108
      • variant (553)
  • Chain 'B':
    Compound: guanylate cyclase soluble subunit beta-1
    Species: Homo sapiens [TaxId:9606]
    Gene: GUCY1B1, GUC1B3, GUCSB3, GUCY1B3
    Database cross-references and differences (RAF-indexed):
  • Heterogens: HEM

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6jt1A (A:)
mfctklkdlkitgecpfsllapgqvpnesseeaagssesckatmpicqdipekniqeslp
qrktsrsrvylhtlaesicklifpeferlnvalqrtlakhkikesrksleredfektiae
qavaagvpvevikeslgeevfkicyeedenilgvvggtlkdflnsfstllkqsshcqeag
krgrledasilcldkeddflhvyyffpkrttslilpgiikaaahvlyetevevslmppcf
hndcsefvnqpyllysvhmkstkpslspskpqsslviptslfcktfpfhfmfdkdmtilq
fgngirrlmnrrdfqgkpnfeeyfeiltpkinqtfsgimtmlnmqfvvrvrrwdnsvkks
srvmdlkgqmiyivessailflgspcvdrledftgrglylsdipihnalrdvvligeqar
aqdglkkrlgklkatleqahqaleeekkktvdllcsifpcevaqqlwqgqvvqakkfsnv
tmlfsdivgftaicsqcsplqvitmlnalytrfdqqcgeldvykvetigdaycvagglhk
esdthavqialmavkmmelsdevmsphgepikmriglhsgsvfagvvgvkmpryclfgnn
vtlankfescsvprkinvspttyrllkdcpgfvftprsreelppnfpseipgichflday
qqgtnskpcfqkkdvedgnanflgkasgid

    Sequence, based on observed residues (ATOM records):
    >6jt1A (A:)
vylhtlaesicklifpeferlnvalqrtlakhkfektiaeqavaagvpvevikeslgeev
fkicyeedenilgvvggtlkdflnsfstllkqssasilcldkeddflhvyyffpkrttsl
ilpgiikaaahvlyetevevslmppcfhndcsefvnqpyllysvhslviptslfcktfpf
hfmfdkdmtilqfgngirrlmnrrdkpnfeeyfeiltpkinqtfsgimtmlnmqfvvrvr
rwsrvmdlkgqmiyivessailflgspcvdrledftgrglylsdipihnalrdvvligeq
araqdglkkrlgklkatleqahqaleeekkktvdllcsifpcevaqqlwqgqvvqakkfs
nvtmlfsdivgftaicsqcsplqvitmlnalytrfdqqcgeldvykvetigdaycvaggl
hkesdthavqialmavkmmelsdevmsphgepikmriglhsgsvfagvvgvkmpryclfg
nnvtlankfescsvprkinvspttyrllkdcpgfvftprsreelppnfpseipgichfld
ay

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6jt1B (B:)
mygfvnhalellvirnygpevwedikkeaqldeegqflvriiyddsktydlvaaaskvln
lnageilqmfgkmffvfcqesgydtilrvlgsnvreflqnldalhdhlatiypgmrapsf
rctdaekgkglilhyysereglqdivigiiktvaqqihgteidmkviqqrneecdhtqfl
ieekeskeedfyedldrfeengtqesrispytfckafpfhiifdrdlvvtqcgnaiyrvl
pqlqpgncsllsvfslvrphidisfhgilshintvfvlrskeglldveklecedeltgte
isclrlkgqmiylpeadsilflcspsvmnlddltrrglylsdiplhdatrdlvllgeqfr
eeykltqeleiltdrlqltlraledekkktdtllysvlppsvanelrhkrpvpakrydnv
tilfsgivgfnafcskhasgegamkivnllndlytrfdtltdsrknpfvykvetvgdkym
tvsglpepcihharsichlaldmmeiagqvqvdgesvqitigihtgevvtgvigqrmpry
clfgntvnltsrtettgekgkinvseytyrclmspensdpqfhlehrgpvsmkgkkepmq
vwflsrkntgteetkqddd

    Sequence, based on observed residues (ATOM records):
    >6jt1B (B:)
mygfvnhalellvirnygpevwedikkeaqldeegqflvriiyddsktydlvaaaskvln
lnageilqmfgkmffvfcqesgydtilrvlgsnvreflqnldalhdhlatiypgmrapsf
rctdaekgkglilhyysereglqdivigiiktvaqqihgteidmkviqqrneecdhtqfl
ieekeskqesrispytfckafpfhiifdrdlvvtqcgnaiyrvlpqlqpgncsllsvfsl
vrphidisfhgilshintvfvlrskeglldsclrlkgqmiylpeadsilflcspsvmnld
dltrrglylsdiplhdatrdlvllgeqfreeykltqeleiltdrlqltlraledekkktd
tllysvlppsvanelrhkrpvpakrydnvtilfsgivgfnafcskhasgegamkivnlln
dlytrfdtltdsrknpfvykvetvgdkymtvsglpepcihharsichlaldmmeiagqvq
vdgesvqitigihtgevvtgvigqrmpryclfgntvnltsrtettgekgkinvseytyrc
lmspensdpqfhlehrgpvsmkgkkepmqvwflsrk