PDB entry 6jrx

View 6jrx on RCSB PDB site
Description: EGFR T790M/C797S in complex with compound 6i
Class: transferase
Keywords: EGFR T790M/C797S, Inhibitor, Complex, TRANSFERASE
Deposited on 2019-04-06, released 2020-04-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-04-15, with a file datestamp of 2020-04-10.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR, ERBB, ERBB1, HER1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533 (4-End)
      • engineered mutation (98)
      • engineered mutation (105)
    Domains in SCOPe 2.08: d6jrxa_
  • Heterogens: 9JO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6jrxA (A:)
gamggeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreat
spkankeildeayvmasvdnphvcrllgicltstvqlimqlmpfgslldyvrehkdnigs
qyllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeekeyha
eggkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekge
rlpqppictidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermhlps
ptdsnfyralmdeedmddvvdadeylipqqg

    Sequence, based on observed residues (ATOM records): (download) 
    >6jrxA (A:)
geapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikelreatspka
nkeildeayvmasvdnphvcrllgicltstvqlimqlmpfgslldyvrehkdnigsqyll
nwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeyhaeggkvpi
kwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekgerlpqppi
ctidvymimvkcwmidadsrpkfreliiefskmardpqrylviqgdermmddvvdadeyl