PDB entry 6jpe

View 6jpe on RCSB PDB site
Description: Crystal structure of FGFR4 kinase domain with irreversible inhibitor 1
Class: transferase/transferase inhibitor
Keywords: FGFR4, irreversible inhibitor, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2019-03-26, released 2020-05-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-11-04, with a file datestamp of 2020-10-30.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: N/A
AEROSPACI score: 0.53 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fibroblast growth factor receptor 4
    Species: Homo sapiens [TaxId:9606]
    Gene: FGFR4, JTK2, TKF
    Database cross-references and differences (RAF-indexed):
    • Uniprot P22455
      • engineered mutation (221)
    Domains in SCOPe 2.08: d6jpea_
  • Heterogens: BYU, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6jpeA (A:)
gpllaglvsldlpldplwefprdrlvlgkplgegafgqvvraeafgmdparpdqastvav
kmlkdnasdkdladlvsemevmkligrhkniinllgvctqegplyvivecaakgnlrefl
rarrppgpdlspdgprssegplsfpvlvscayqvargmqylesrkcihrdlaarnvlvte
dnvmkiadfglargvhhidyykktsngrlpvkwmapealfdevythqsdvwsfgillwei
ftlggspypgipveelfsllreghrmdrpphcppelyglmrecwhaapsqrptfkqlvea
ldkvllavsee

    Sequence, based on observed residues (ATOM records): (download) 
    >6jpeA (A:)
ldlpldplwefprdrlvlgkplgeggqvvraeafgmdparpdqastvavkmlkdnasdkd
ladlvsemevmkligrhkniinllgvctqegplyvivecaakgnlreflrarrppgpdls
pdgprssegplsfpvlvscayqvargmqylesrkcihrdlaarnvlvtednvmkiadfgl
argvhhidyykktsngrlpvkwmapealfdevythqsdvwsfgillweiftlggspypgi
pveelfsllreghrmdrpphcppelyglmrecwhaapsqrptfkqlvealdkvllavs