PDB entry 6joi

View 6joi on RCSB PDB site
Description: Crystal structure of PDGFRA T674I in complex with crenolanib by co-crystallization
Class: oncoprotein
Keywords: PDGFRA, T674I, Inhibitor, crenolanib, ONCOPROTEIN
Deposited on 2019-03-22, released 2020-03-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-03-25, with a file datestamp of 2020-03-20.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: N/A
AEROSPACI score: 0.12 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Platelet-derived growth factor receptor alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: PDGFRA, PDGFR2, RHEPDGFRA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P16234
      • engineered mutation (147)
    • Uniprot P16234 (Start-374)
    Domains in SCOPe 2.08: d6joia_
  • Heterogens: 6T2, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6joiA (A:)
hhhhhhdydipttenlyfqgamdkqkpryeirwrviesispdgheyiyvdpmqlpydsrw
efprdglvlgrvlgsgafgkvvegtayglsrsqpvmkvavkmlkptarssekqalmselk
imthlgphlnivnllgactksgpiyiiieycfygdlvnylhknrdsflshkkksmldsev
knllsddnsegltlldllsftyqvargmeflaskncvhrdlaarnvllaqgkivkicdfg
lardimhdsnyvskgstflpvkwmapesifdnlyttlsdvwsygillweifslggtpypg
mmvdstfynkiksgyrmakpdhatsevyeimvkcwnsepekrpsfyhlseivenllpgqy
kksyekihldflksd

    Sequence, based on observed residues (ATOM records): (download) 
    >6joiA (A:)
gheyiyvdpmqlpydsrwefprdglvlgrvlgsgafgkvvegtayglsrsqpvmkvavkm
lkptarssekqalmselkimthlgphlnivnllgactksgpiyiiieycfygdlvnylhk
nrdsflgltlldllsftyqvargmeflaskncvhrdlaarnvllaqgkivkicdfgltfl
pvkwmapesifdnlyttlsdvwsygillweifslggtpypgmmvdstfynkiksgyrmak
pdhatsevyeimvkcwnsepekrpsfyhlseivenllpgqykksyekihldflksd