PDB entry 6jlw

View 6jlw on RCSB PDB site
Description: eif2 - eif2b complex
Deposited on 2019-03-07, released 2019-05-01
Made obsolete by 6k71 on 2019-07-10

The last revision was dated 2019-07-10, with a file datestamp of 2019-07-05.
Experiment type: EM
Resolution: 4.3 Å
R-factor: N/A
AEROSPACI score: 0.02 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Translation initiation factor eIF-2B subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B1, EIF2BA
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Translation initiation factor eIF-2B subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B1, EIF2BA
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: Translation initiation factor eIF-2B subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B2, EIF2BB
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: Translation initiation factor eIF-2B subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B2, EIF2BB
    Database cross-references and differences (RAF-indexed):
  • Chain 'E':
    Compound: Translation initiation factor eIF-2B subunit gamma
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B3
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: Translation initiation factor eIF-2B subunit gamma
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B3
    Database cross-references and differences (RAF-indexed):
  • Chain 'G':
    Compound: Translation initiation factor eIF-2B subunit delta
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B4, EIF2BD
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: Translation initiation factor eIF-2B subunit delta
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B4, EIF2BD
    Database cross-references and differences (RAF-indexed):
  • Chain 'I':
    Compound: Translation initiation factor eIF-2B subunit epsilon
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B5, EIF2BE
    Database cross-references and differences (RAF-indexed):
  • Chain 'J':
    Compound: Translation initiation factor eIF-2B subunit epsilon
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2B5, EIF2BE
    Database cross-references and differences (RAF-indexed):
  • Chain 'K':
    Compound: Eukaryotic translation initiation factor 2 subunit 1
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2S1, EIF2A
    Database cross-references and differences (RAF-indexed):
  • Chain 'M':
    Compound: eIF2b
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6JLW (0-15)
  • Chain 'P':
    Compound: Eukaryotic translation initiation factor 2 subunit 3
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF2S3, EIF2G
    Database cross-references and differences (RAF-indexed):

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >6jlwA (A:)
mddkelieyfksqmkedpdmasavaairtlleflkrdkgetiqglranltsaietlcgvd
ssvavssggelflrfislasleysdyskckkimiergelflrrislsrnkiadlchtfik
dgatilthaysrvvlrvleaavaakkrfsvyvtesqpdlsgkkmakalchlnvpvtvvld
aavgyimekadlvivgaegvvenggiinkigtnqmavcakaqnkpfyvvaesfkfvrlfp
lnqqdvpdkfkykadtlkvaqtgqdlkeehpwvdytapslitllftdlgvltpsavsdel
iklyl

    Sequence, based on observed residues (ATOM records):
    >6jlwA (A:)
kelieyfksqmkedpdmasavaairtlleflkrglranltsaietlcgvdssvavssgge
lflrfiskimiergelflrrislsrnkiadlchtfikdgatilthaysrvvlrvleaava
akkrfsvyvtesqpdlsgkkmakalchlnvpvtvvldaavgyimekadlvivgaegvven
ggiinkigtnqmavcakaqnkpfyvvaesfkfvrlfplnqqdvpdkfkyhpwvdytapsl
itllftdlgvltpsavsdeliklyl

  • Chain 'B':
    Sequence, based on SEQRES records:
    >6jlwB (B:)
mddkelieyfksqmkedpdmasavaairtlleflkrdkgetiqglranltsaietlcgvd
ssvavssggelflrfislasleysdyskckkimiergelflrrislsrnkiadlchtfik
dgatilthaysrvvlrvleaavaakkrfsvyvtesqpdlsgkkmakalchlnvpvtvvld
aavgyimekadlvivgaegvvenggiinkigtnqmavcakaqnkpfyvvaesfkfvrlfp
lnqqdvpdkfkykadtlkvaqtgqdlkeehpwvdytapslitllftdlgvltpsavsdel
iklyl

    Sequence, based on observed residues (ATOM records):
    >6jlwB (B:)
kelieyfksqmkedpdmasavaairtlleflkrglranltsaietlcgvdssvavssgge
lflrfiskimiergelflrrislsrnkiadlchtfikdgatilthaysrvvlrvleaava
akkrfsvyvtesqpdlsgkkmakalchlnvpvtvvldaavgyimekadlvivgaegvven
ggiinkigtnqmavcakaqnkpfyvvaesfkfvrlfplnqqdvpdkfkyhpwvdytapsl
itllftdlgvltpsavsdeliklyl

  • Chain 'C':
    Sequence, based on SEQRES records:
    >6jlwC (C:)
mpgsaakgselseriesfvetlkrgggprsseemaretlgllrqiitdhrwsnagelmel
irregrrmtaaqpsettvgnmvrrvlkiireeygrlhgrsdesdqqeslhklltsgglne
dfsfhyaqlqsniieainellvelegtmeniaaqalehihsnevimtigfsrtveaflke
aarkrkfhvivaecapfcqghemavnlskagiettvmtdaaifavmsrvnkviigtktil
angalravtgthtlalaakhhstplivcapmfklspqfpneedsfhkfvapeevlpfteg
dilekvsvhcpvfdyvppelitlfisniggnapsyiyrlmselyhpddhvl

    Sequence, based on observed residues (ATOM records):
    >6jlwC (C:)
gselseriesfvetlkrgggprsseemaretlgllrqiitdhrwsnagelmelirregrr
mtaaqpsettvgnmvrrvlkiireeygrlhghyaqlqsniieainellvelegtmeniaa
qalehihsnevimtigfsrtveaflkeaarkrkfhvivaecapfcqghemavnlskagie
ttvmtdaaifavmsrvnkviigtktilangalravtgthtlalaakhhstplivcapmfk
lspqfpneedsfhkfvapeevlpftegdilekvsvhcpvfdyvppelitlfisniggnap
syiyrlmselyhpddhvl

  • Chain 'D':
    Sequence, based on SEQRES records:
    >6jlwD (D:)
mpgsaakgselseriesfvetlkrgggprsseemaretlgllrqiitdhrwsnagelmel
irregrrmtaaqpsettvgnmvrrvlkiireeygrlhgrsdesdqqeslhklltsgglne
dfsfhyaqlqsniieainellvelegtmeniaaqalehihsnevimtigfsrtveaflke
aarkrkfhvivaecapfcqghemavnlskagiettvmtdaaifavmsrvnkviigtktil
angalravtgthtlalaakhhstplivcapmfklspqfpneedsfhkfvapeevlpfteg
dilekvsvhcpvfdyvppelitlfisniggnapsyiyrlmselyhpddhvl

    Sequence, based on observed residues (ATOM records):
    >6jlwD (D:)
gselseriesfvetlkrgggprsseemaretlgllrqiitdhrwsnagelmelirregrr
mtaaqpsettvgnmvrrvlkiireeygrlhghyaqlqsniieainellvelegtmeniaa
qalehihsnevimtigfsrtveaflkeaarkrkfhvivaecapfcqghemavnlskagie
ttvmtdaaifavmsrvnkviigtktilangalravtgthtlalaakhhstplivcapmfk
lspqfpneedsfhkfvapeevlpftegdilekvsvhcpvfdyvppelitlfisniggnap
syiyrlmselyhpddhvl

  • Chain 'E':
    Sequence, based on SEQRES records:
    >6jlwE (E:)
mefqavvmavgggsrmtdltssipkpllpvgnkpliwyplnllervgfeevivvttrdvq
kalcaefkmkmkpdivcipddadmgtadslryiypklktdvlvlscdlitdvalhevvdl
fraydaslamlmrkgqdsiepvpgqkgkkkaveqrdfigvdstgkrllfmaneadldeel
vikgsilqkhprirfhtglvdahlyclkkyivdflmengsitsirselipylvrkqfssa
ssqqgqeekeedlkkkelksldiysfikeantlnlapydacwnacrgdrwedlsrsqvrc
yvhimkeglcsrvstlglymeanrqvpkllsalcpeeppvhssaqivskhlvgvdsligp
etqigekssikrsvigssclikdrvtitncllmnsvtveegsniqgsvicnnaviekgad
ikdcligsgqrieakakrvnevivgndqlmei

    Sequence, based on observed residues (ATOM records):
    >6jlwE (E:)
mefqavvmavggpllpvgnkpliwyplnllervgfeevivvttkalcaefkmkmkpdivc
ipddadmgtadslryiypklktdvlvlscdlitdvalhevvdlfraydaslamlmrkrdf
igvdstgkrllfmaneadldeelvikgsilqkhprirfhtglvdahlyclkkyivdflme
ngsitsirselipylvrkqsassqsldiysfitlnlapydacwnacrgdrwedssaqivs
khlvgvdsligpetqigekssikrsvigssclikdrvtitncllmnsvtveegsniqgsv
icnnaviekgadikdcligsgqrieakakrvneviv

  • Chain 'F':
    Sequence, based on SEQRES records:
    >6jlwF (F:)
mefqavvmavgggsrmtdltssipkpllpvgnkpliwyplnllervgfeevivvttrdvq
kalcaefkmkmkpdivcipddadmgtadslryiypklktdvlvlscdlitdvalhevvdl
fraydaslamlmrkgqdsiepvpgqkgkkkaveqrdfigvdstgkrllfmaneadldeel
vikgsilqkhprirfhtglvdahlyclkkyivdflmengsitsirselipylvrkqfssa
ssqqgqeekeedlkkkelksldiysfikeantlnlapydacwnacrgdrwedlsrsqvrc
yvhimkeglcsrvstlglymeanrqvpkllsalcpeeppvhssaqivskhlvgvdsligp
etqigekssikrsvigssclikdrvtitncllmnsvtveegsniqgsvicnnaviekgad
ikdcligsgqrieakakrvnevivgndqlmei

    Sequence, based on observed residues (ATOM records):
    >6jlwF (F:)
mefqavvmavggpllpvgnkpliwyplnllervgfeevivvttkalcaefkmkmkpdivc
ipddadmgtadslryiypklktdvlvlscdlitdvalhevvdlfraydaslamlmrkrdf
igvdstgkrllfmaneadldeelvikgsilqkhprirfhtglvdahlyclkkyivdflme
ngsitsirselipylvrkqsassqsldiysfiapydacwnacrgdrwedssaqivskhlv
gvdsligpetqigekssikrsvigssclikdrvtitncllmnsvtveegsniqgsvicnn
aviekgadikdcligsgqrieakakrvneviv

  • Chain 'G':
    Sequence, based on SEQRES records:
    >6jlwG (G:)
maavavavredsgsgmkaelppgpgavgremtkeeklqlrkekkqqkkkrkeekgaepet
gsavsaaqcqvgptrelpesgiqlgtprekvpagrskaelraerrakqeaeralkqarkg
eqggpppkaspstagetpsgvkrlpeypqvddlllrrlvkkperqqvptrkdygskvslf
shlpqysrqnsltqfmsipssvihpamvrlglqysqglvsgsnarciallralqqviqdy
ttppneelsrdlvnklkpymsfltqcrplsasmhnaikflnkeitsvgsskreeeaksel
raaidryvqekivlaaqaisrfayqkisngdvilvygcsslvsrilqeawtegrrfrvvv
vdsrpwlegrhtlrslvhagvpasyllipaasyvlpevskvllgahallangsvmsrvgt
aqlalvarahnvpvlvccetykfcervqtdafvsnelddpddlqckrgehvalanwqnha
slrllnlvydvtppelvdlvitelgmipcssvpvvlrvkssdq

    Sequence, based on observed residues (ATOM records):
    >6jlwG (G:)
qvptrkdygskvslfshlpqysrqnsltqfmsipssvihpamvrlglqysqglvsgsnar
ciallralqqviqdyttppneelsrdlvnklkpymsfltqcrplsasmhnaikflnkeit
svgsskreeeakselraaidryvqekivlaaqaisrfayqkisngdvilvygcsslvsri
lqeawtegrrfrvvvvdsrpwlegrhtlrslvhagvpasyllipaasyvlpevskvllga
hallangsvmsrvgtaqlalvarahnvpvlvccetykfcervqtdafvsnelddpddlqc
krgehvalanwqnhaslrllnlvydvtppelvdlvitelgmipcssvpvvlrvkssd

  • Chain 'H':
    Sequence, based on SEQRES records:
    >6jlwH (H:)
maavavavredsgsgmkaelppgpgavgremtkeeklqlrkekkqqkkkrkeekgaepet
gsavsaaqcqvgptrelpesgiqlgtprekvpagrskaelraerrakqeaeralkqarkg
eqggpppkaspstagetpsgvkrlpeypqvddlllrrlvkkperqqvptrkdygskvslf
shlpqysrqnsltqfmsipssvihpamvrlglqysqglvsgsnarciallralqqviqdy
ttppneelsrdlvnklkpymsfltqcrplsasmhnaikflnkeitsvgsskreeeaksel
raaidryvqekivlaaqaisrfayqkisngdvilvygcsslvsrilqeawtegrrfrvvv
vdsrpwlegrhtlrslvhagvpasyllipaasyvlpevskvllgahallangsvmsrvgt
aqlalvarahnvpvlvccetykfcervqtdafvsnelddpddlqckrgehvalanwqnha
slrllnlvydvtppelvdlvitelgmipcssvpvvlrvkssdq

    Sequence, based on observed residues (ATOM records):
    >6jlwH (H:)
qvptrkdygskvslfshlpqysrqnsltqfmsipssvihpamvrlglqysqglvsgsnar
ciallralqqviqdyttppneelsrdlvnklkpymsfltqcrplsasmhnaikflnkeit
svgsskreeeakselraaidryvqekivlaaqaisrfayqkisngdvilvygcsslvsri
lqeawtegrrfrvvvvdsrpwlegrhtlrslvhagvpasyllipaasyvlpevskvllga
hallangsvmsrvgtaqlalvarahnvpvlvccetykfcervqtdafvsnelddpddlqc
krgehvalanwqnhaslrllnlvydvtppelvdlvitelgmipcssvpvvlrvkssd

  • Chain 'I':
    Sequence, based on SEQRES records:
    >6jlwI (I:)
maapvvappgvvvsrankrsgagpggsggggargaeeepppplqavlvadsfdrrffpis
kdqprvllplanvalidytlefltatgvqetfvfccwkaaqikehllkskwcrptslnvv
riitselyrslgdvlrdvdakalvrsdfllvygdvisninitraleehrlrrkleknvsv
mtmifkesspshptrchednvvvavdsttnrvlhfqktqglrrfafplslfqgssdgvev
rydlldchisicspqvaqlftdnfdyqtrddfvrgllvneeilgnqihmhvtakeygarv
snlhmysavcadvirrwvypltpeanftdsttqscthsrhniyrgpevslghgsileenv
llgsgtvigsncfitnsvigpgchigdnvvldqtylwqgvrvaagaqihqsllcdnaevk
ervtlkprsvltsqvvvgpnitlpegsvislhppdaeededdgefsddsgadqekdkvkm
kgynpaevgaagkgylwkaagmnmeeeeelqqnlwglkinmeeeseseseqsmdseepds
rggspqmddikvfqnevlgtlqrgkeeniscdnlvleinslkyaynislkevmqvlshvv
lefplqqmdspldssrycalllpllkawspvfrnyikraadhlealaaiedfflehealg
ismakvlmafyqleilaeetilswfsqrdttdkgqqlrknqqlqrfiqwlkeaeeessed
d

    Sequence, based on observed residues (ATOM records):
    >6jlwI (I:)
pplqavlvadsfdrrffpiskdqprvllplanvalidytlefltatgvqetfvfccwkaa
qikehllkskwcrptslnvvriitselyrslgdvlrdvdakalvrsdfllvygdvisnin
itraleehrlrrkleknvsvmtmifkesspshptrchednvvvavdsttnrvlhfqktqg
lrrfafplslfqgssdgvevrydlldchisicspqvaqlftdnfdyqtrddfvrgllvnn
qihmhvtakeygarvsnlhmysavcadvirrwvypltpeanftdsttqscthsrhniyrg
pevslghgsileenvllgsgtvigsncfitnsvigpgchigdnvvldqtylwqgvrvaag
aqihqsllcdnaevkervtlkprsvltsqvvvgpnitlpegsvislhppdaeededdgef
s

  • Chain 'J':
    Sequence, based on SEQRES records:
    >6jlwJ (J:)
maapvvappgvvvsrankrsgagpggsggggargaeeepppplqavlvadsfdrrffpis
kdqprvllplanvalidytlefltatgvqetfvfccwkaaqikehllkskwcrptslnvv
riitselyrslgdvlrdvdakalvrsdfllvygdvisninitraleehrlrrkleknvsv
mtmifkesspshptrchednvvvavdsttnrvlhfqktqglrrfafplslfqgssdgvev
rydlldchisicspqvaqlftdnfdyqtrddfvrgllvneeilgnqihmhvtakeygarv
snlhmysavcadvirrwvypltpeanftdsttqscthsrhniyrgpevslghgsileenv
llgsgtvigsncfitnsvigpgchigdnvvldqtylwqgvrvaagaqihqsllcdnaevk
ervtlkprsvltsqvvvgpnitlpegsvislhppdaeededdgefsddsgadqekdkvkm
kgynpaevgaagkgylwkaagmnmeeeeelqqnlwglkinmeeeseseseqsmdseepds
rggspqmddikvfqnevlgtlqrgkeeniscdnlvleinslkyaynislkevmqvlshvv
lefplqqmdspldssrycalllpllkawspvfrnyikraadhlealaaiedfflehealg
ismakvlmafyqleilaeetilswfsqrdttdkgqqlrknqqlqrfiqwlkeaeeessed
d

    Sequence, based on observed residues (ATOM records):
    >6jlwJ (J:)
pplqavlvadsfdrrffpiskdqprvllplanvalidytlefltatgvqetfvfccwkaa
qikehllkskwcrptslnvvriitselyrslgdvlrdvdakalvrsdfllvygdvisnin
itraleehrlrrkleknvsvmtmifkesspshptrchednvvvavdsttnrvlhfqktqg
lrrfafplslfqgssdgvevrydlldchisicspqvaqlftdnfdyqtrddfvrgllvnn
qihmhvtakeygarvsnlhmysavcadvirrwvypltpeanftdsttqscthsrhniyrg
pevslghgsileenvllgsgtvigsncfitnsvigpgchigdnvvldqtylwqgvrvaag
aqihqsllcdnaevkervtlkprsvltsqvvvgpnitlpegsvislhppdaeededdgef
smddikvfqnevlgtlqrgkeeniscdnlvleinslkyaynislkevmqvlshvvlefpl
qqmdspldssrycalllpllkawspvfrnyikraadhlealaaiedfflehealgismak
vlmafyqleilaeetilswfsqrddkgqqlrknqqlqrfiqwlkeaee

  • Chain 'K':
    Sequence, based on SEQRES records:
    >6jlwK (K:)
mpglscrfyqhkfpevedvvmvnvrsiaemgayvslleynniegmillselsrrrirsin
klirigrnecvvvirvdkekgyidlskrrvspeeaikcedkftksktvysilrhvaevle
ytkdeqleslfqrtawvfddkykrpgygaydafkhavsdpsildsldlnederevlinni
nrrltpqavkiradievacygyegidavkealraglncstenmpikinliappryvmttt
tlerteglsvlsqamavikekieekrgvfnvqmepkvvtdtdetelarqmerlerenaev
dgdddaeemeakaed

    Sequence, based on observed residues (ATOM records):
    >6jlwK (K:)
rfyqhkfpevedvvmvnvrsiaemgayvslleynniegmillselsrrrirsinklirig
rnecvvvirvdkekgyidlskrrvspeeaikcedkftksktvysilrhvaevleytkdeq
leslfqrtawvfddkykrpgygaydafkhavsdpsildsldlnederevlinninrrltp
qavkiradievacygyegidavkealraglncstenmpikinliappryvmttttlerte
glsvlsqamavikekieekrgvfnv

  • Chain 'M':
    Sequence; same for both SEQRES and ATOM records:
    >6jlwM (M:)
ekeyvemldrlysklp

  • Chain 'P':
    Sequence, based on SEQRES records:
    >6jlwP (P:)
maggeagvtlgqphlsrqdlttldvtkltplshevisrqatinigtighvahgkstvvka
isgvhtvrfknelernitiklgyanakiyklddpscprpecyrscgsstpdefptdipgt
kgnfklvrhvsfvdcpghdilmatmlngaavmdaallliagnescpqpqtsehlaaieim
klkhililqnkidlvkesqakeqyeqilafvqgtvaegapiipisaqlkynievvceyiv
kkipvpprdftseprlivirsfdvnkpgcevddlkggvaggsilkgvlkvgqeievrpgi
vskdsegklmckpifskivslfaehndlqyaapggligvgtkidptlcradrmvgqvlga
vgalpeifteleisyfllrrllgvrtegdkkaakvqklsknevlmvnigslstggrvsav
kadlgkivltnpvctevgekialsrrvekhwrligwgqirrgvtikptvddd

    Sequence, based on observed residues (ATOM records):
    >6jlwP (P:)
atinigtighvahgkstvvkaisgvhtvrfknelernitiklgyanakiyklddpscprp
ecyrgtkgnfklvrhvsfvdcpghdilmatmlngaavmdaallliagnescpqpqtsehl
aaieimklkhililqnkidlvkesqakeqyeqilafvqgtvaegapiipisaqlkyniev
vceyivkkipvpprdftseprlivirsfdvnkpgcevddlkggvaggsilkgvlkvgqei
evrpgivskdsegklmckpifskivslfaehndlqyaapggligvgtkidptlcradrmv
gqvlgavgalpeifteleisyfllrrllgvrtegdkkaakvqklsknevlmvnigslstg
grvsavkadlgkivltnpvctevgekialsrrvekhwrligwgqir