PDB entry 6jl5

View 6jl5 on RCSB PDB site
Description: Crystal structure of aspartate transcarbamoylase from Trypanosoma cruzi in complex with aspartate (Asp) and phosphate (Pi).
Class: transferase
Keywords: ATCase, Pyrimidine metabolism, TRANSFERASE
Deposited on 2019-03-04, released 2020-03-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-03-04, with a file datestamp of 2020-02-28.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: aspartate carbamoyltransferase
    Species: Trypanosoma cruzi [TaxId:5693]
    Gene: C3747_31g124
    Database cross-references and differences (RAF-indexed):
    • Uniprot O15636 (4-329)
      • expression tag (2-3)
    Domains in SCOPe 2.08: d6jl5a1, d6jl5a2, d6jl5a3
  • Chain 'B':
    Compound: aspartate carbamoyltransferase
    Species: Trypanosoma cruzi [TaxId:5693]
    Gene: C3747_31g124
    Database cross-references and differences (RAF-indexed):
    • Uniprot O15636 (4-329)
      • expression tag (3)
    Domains in SCOPe 2.08: d6jl5b1, d6jl5b2, d6jl5b3
  • Chain 'C':
    Compound: aspartate carbamoyltransferase
    Species: Trypanosoma cruzi [TaxId:5693]
    Gene: C3747_31g124
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6jl5c1, d6jl5c2
  • Chain 'D':
    Compound: aspartate carbamoyltransferase
    Species: Trypanosoma cruzi [TaxId:5693]
    Gene: C3747_31g124
    Database cross-references and differences (RAF-indexed):
    • Uniprot O15636 (4-329)
      • expression tag (2-3)
    Domains in SCOPe 2.08: d6jl5d1, d6jl5d2, d6jl5d3
  • Chain 'E':
    Compound: aspartate carbamoyltransferase
    Species: Trypanosoma cruzi [TaxId:5693]
    Gene: C3747_31g124
    Database cross-references and differences (RAF-indexed):
    • Uniprot O15636 (4-329)
      • expression tag (0-3)
    Domains in SCOPe 2.08: d6jl5e1, d6jl5e2, d6jl5e3
  • Chain 'F':
    Compound: aspartate carbamoyltransferase
    Species: Trypanosoma cruzi [TaxId:5693]
    Gene: C3747_31g124
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6jl5f1, d6jl5f2
  • Heterogens: PO4, ASP, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6jl5A (A:)
prgsmlelppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtp
lffedssrtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhpr
qdaieealsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtv
hsllkllvrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksd
vlyttrlqkerfmastsddaaalqsfaakaditidaarmrlakekmivmhplprndelst
tvdadpraayfrqmrygmfmrmailwsvla

    Sequence, based on observed residues (ATOM records): (download) 
    >6jl5A (A:)
gsmlelppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtplf
fedssrtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhprqd
aieealsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtvhs
llkllvrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksdvl
yttrlqaaalqsfaakaditidaarmrlakekmivmhplprndelsttvdadpraayfrq
mrygmfmrmailwsvla

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6jl5B (B:)
prgsmlelppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtp
lffedssrtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhpr
qdaieealsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtv
hsllkllvrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksd
vlyttrlqkerfmastsddaaalqsfaakaditidaarmrlakekmivmhplprndelst
tvdadpraayfrqmrygmfmrmailwsvla

    Sequence, based on observed residues (ATOM records): (download) 
    >6jl5B (B:)
smlelppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtplff
edssrtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhprqda
ieealsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtvhsl
lkllvrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksdvly
ttrlqkerfmastsddaaalqsfaakaditidaarmrlakekmivmhplprndelsttvd
adpraayfrqmrygmfmrmailwsvla

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6jl5C (C:)
prgsmlelppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtp
lffedssrtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhpr
qdaieealsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtv
hsllkllvrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksd
vlyttrlqkerfmastsddaaalqsfaakaditidaarmrlakekmivmhplprndelst
tvdadpraayfrqmrygmfmrmailwsvla

    Sequence, based on observed residues (ATOM records): (download) 
    >6jl5C (C:)
lelppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtplffed
ssrtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhprqdaie
ealsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtvhsllk
llvrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksdvlytt
rlqkerditidaarmrlakekmivmhplprndelsttvdadpraayfrqmrygmfmrmai
lwsvla

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6jl5D (D:)
prgsmlelppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtp
lffedssrtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhpr
qdaieealsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtv
hsllkllvrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksd
vlyttrlqkerfmastsddaaalqsfaakaditidaarmrlakekmivmhplprndelst
tvdadpraayfrqmrygmfmrmailwsvla

    Sequence, based on observed residues (ATOM records): (download) 
    >6jl5D (D:)
gsmlelppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtplf
fedssrtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhprqd
aieealsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtvhs
llkllvrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksdvl
yttrlqkerkaditidaarmrlakekmivmhplprndelsttvdadpraayfrqmrygmf
mrmailwsvla

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6jl5E (E:)
prgsmlelppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtp
lffedssrtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhpr
qdaieealsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtv
hsllkllvrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksd
vlyttrlqkerfmastsddaaalqsfaakaditidaarmrlakekmivmhplprndelst
tvdadpraayfrqmrygmfmrmailwsvla

    Sequence, based on observed residues (ATOM records): (download) 
    >6jl5E (E:)
prgsmlelppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtp
lffedssrtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhpr
qdaieealsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtv
hsllkllvrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksd
vlyttrlqkerfkaditidaarmrlakekmivmhplprndelsttvdadpraayfrqmry
gmfmrmailwsvla

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6jl5F (F:)
prgsmlelppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtp
lffedssrtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhpr
qdaieealsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtv
hsllkllvrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksd
vlyttrlqkerfmastsddaaalqsfaakaditidaarmrlakekmivmhplprndelst
tvdadpraayfrqmrygmfmrmailwsvla

    Sequence, based on observed residues (ATOM records): (download) 
    >6jl5F (F:)
elppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtplffeds
srtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhprqdaiee
alsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtvhsllkl
lvrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksdvlyttr
lqkerfmastsddaaalqsfaakaditidaarmrlakekmivmhplprndelsttvdadp
raayfrqmrygmfmrmailwsvla