PDB entry 6jkt

View 6jkt on RCSB PDB site
Description: Crystal structure of aspartate transcarbamoylase from Trypanosoma cruzi in complex with N-(PHOSPHONACETYL)-L-ASPARTIC ACID (PALA).
Class: transferase
Keywords: ATCase, Pyrimidine metabolism, TRANSFERASE
Deposited on 2019-03-01, released 2020-03-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-03-04, with a file datestamp of 2020-02-28.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: aspartate carbamoyltransferase
    Species: Trypanosoma cruzi [TaxId:5693]
    Gene: C3747_31g124
    Database cross-references and differences (RAF-indexed):
    • Uniprot O15636 (2-327)
      • expression tag (0-1)
    Domains in SCOPe 2.08: d6jkta1, d6jkta2, d6jkta3
  • Chain 'B':
    Compound: aspartate carbamoyltransferase
    Species: Trypanosoma cruzi [TaxId:5693]
    Gene: C3747_31g124
    Database cross-references and differences (RAF-indexed):
    • Uniprot O15636 (2-327)
      • expression tag (0-1)
    Domains in SCOPe 2.08: d6jktb1, d6jktb2, d6jktb3
  • Chain 'C':
    Compound: aspartate carbamoyltransferase
    Species: Trypanosoma cruzi [TaxId:5693]
    Gene: C3747_31g124
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6jktc1, d6jktc2
  • Chain 'D':
    Compound: aspartate carbamoyltransferase
    Species: Trypanosoma cruzi [TaxId:5693]
    Gene: C3747_31g124
    Database cross-references and differences (RAF-indexed):
    • Uniprot O15636 (2-327)
      • expression tag (1)
    Domains in SCOPe 2.08: d6jktd1, d6jktd2, d6jktd3
  • Chain 'E':
    Compound: aspartate carbamoyltransferase
    Species: Trypanosoma cruzi [TaxId:5693]
    Gene: C3747_31g124
    Database cross-references and differences (RAF-indexed):
    • Uniprot O15636 (2-327)
      • expression tag (1)
    Domains in SCOPe 2.08: d6jkte1, d6jkte2, d6jkte3
  • Chain 'F':
    Compound: aspartate carbamoyltransferase
    Species: Trypanosoma cruzi [TaxId:5693]
    Gene: C3747_31g124
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6jktf1, d6jktf2
  • Heterogens: PAL, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6jktA (A:)
gsmlelppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtplf
fedssrtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhprqd
aieealsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtvhs
llkllvrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksdvl
yttrlqkerfmastsddaaalqsfaakaditidaarmrlakekmivmhplprndelsttv
dadpraayfrqmrygmfmrmailwsvla

    Sequence, based on observed residues (ATOM records): (download) 
    >6jktA (A:)
gsmlelppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtplf
fedssrtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhprqd
aieealsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtvhs
llkllvrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksdvl
yttrlqkerfditidaarmrlakekmivmhplprndelsttvdadpraayfrqmrygmfm
rmailwsvla

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6jktB (B:)
gsmlelppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtplf
fedssrtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhprqd
aieealsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtvhs
llkllvrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksdvl
yttrlqkerfmastsddaaalqsfaakaditidaarmrlakekmivmhplprndelsttv
dadpraayfrqmrygmfmrmailwsvla

    Sequence, based on observed residues (ATOM records): (download) 
    >6jktB (B:)
gsmlelppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtplf
fedssrtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhprqd
aieealsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtvhs
llkllvrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksdvl
yttrlqkerfditidaarmrlakekmivmhplprndelsttvdadpraayfrqmrygmfm
rmailwsvla

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6jktC (C:)
gsmlelppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtplf
fedssrtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhprqd
aieealsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtvhs
llkllvrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksdvl
yttrlqkerfmastsddaaalqsfaakaditidaarmrlakekmivmhplprndelsttv
dadpraayfrqmrygmfmrmailwsvla

    Sequence, based on observed residues (ATOM records): (download) 
    >6jktC (C:)
lppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtplffedss
rtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhprqdaieea
lsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtvhsllkll
vrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksdvlyttrl
qkerfmastsddaaalqsfaakaditidaarmrlakekmivmhplprndelsttvdadpr
aayfrqmrygmfmrmailwsvla

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6jktD (D:)
gsmlelppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtplf
fedssrtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhprqd
aieealsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtvhs
llkllvrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksdvl
yttrlqkerfmastsddaaalqsfaakaditidaarmrlakekmivmhplprndelsttv
dadpraayfrqmrygmfmrmailwsvla

    Sequence, based on observed residues (ATOM records): (download) 
    >6jktD (D:)
smlelppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtplff
edssrtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhprqda
ieealsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtvhsl
lkllvrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksdvly
ttrlqkerfdaaalqsfaakaditidaarmrlakekmivmhplprndelsttvdadpraa
yfrqmrygmfmrmailwsvla

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6jktE (E:)
gsmlelppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtplf
fedssrtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhprqd
aieealsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtvhs
llkllvrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksdvl
yttrlqkerfmastsddaaalqsfaakaditidaarmrlakekmivmhplprndelsttv
dadpraayfrqmrygmfmrmailwsvla

    Sequence, based on observed residues (ATOM records): (download) 
    >6jktE (E:)
smlelppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtplff
edssrtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhprqda
ieealsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtvhsl
lkllvrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksdvly
ttrlqkerfmastsddaaalqsfaakaditidaarmrlakekmivmhplprndelsttvd
adpraayfrqmrygmfmrmailwsvla

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6jktF (F:)
gsmlelppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtplf
fedssrtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhprqd
aieealsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtvhs
llkllvrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksdvl
yttrlqkerfmastsddaaalqsfaakaditidaarmrlakekmivmhplprndelsttv
dadpraayfrqmrygmfmrmailwsvla

    Sequence, based on observed residues (ATOM records): (download) 
    >6jktF (F:)
elppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtplffeds
srtfssfcaamirlggsvvnfkvetladtirtldsysdvlvmrhprqdaieealsvaqhp
ilnagngagehptqalldtltihselgsvdgitialigdlkmgrtvhsllkllvrnfsik
cvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksdvlyttrlqkerfdi
tidaarmrlakekmivmhplprndelsttvdadpraayfrqmrygmfmrmailwsvla